January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Clinical efficacy of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of II° lumbar isthmic spondylolisthesis: A retrospective cohort study.
Authors:Zhang B, Ma JS, Feng P, Hu Y, Liu JL, Kong QQ
Institution:Department of Orthopedics Surgery, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, Sichuan, China.; Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Journal:Medicine (Baltimore). 2023 Oct 6;102(40):e35420. doi: 10.1097/MD.0000000000035420.

2:Differences in imaging and clinical characteristics are associated with higher rates of decompression-fusion versus decompression-alone in women compared to men for lumbar degenerative spondylolisthesis.
Authors:Fong AM, Duculan R, Endo Y, Carrino JA, Cammisa FP, Hughes AP, Lebl DR, Farmer JC, Huang RC, Sandhu HS, Mancuso CA, Girardi FP, Sama AA
Institution:Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021, USA.
Journal:Eur Spine J. 2023 Dec;32(12):4184-4191. doi: 10.1007/s00586-023-07958-0. Epub 2023 Oct 5.

3:Management of High-Grade Dysplastic Spondylolisthesis.
Authors:Polly DW Jr, Haselhuhn JJ, Soriano PBO, Odland K, Jones KE
Institution:Department of Orthopedic Surgery, University of Minnesota, 2450 Riverside Avenue South, Suite R200, Minneapolis, MN 55454, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA. Electronic address: pollydw@umn.edu.
Journal:Neurosurg Clin N Am. 2023 Oct;34(4):567-572. doi: 10.1016/j.nec.2023.06.003. Epub 2023 Jul 23.

4:Oblique lateral interbody fusion (OLIF) compared with unilateral biportal endoscopic lumbar interbody fusion (ULIF) for degenerative lumbar spondylolisthesis: a 2-year follow-up study.
Authors:Cao S, Fan B, Song X, Wang Y, Yin W
Institution:Department of Orthopaedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. hydywz@163.com.
Journal:J Orthop Surg Res. 2023 Aug 24;18(1):621. doi: 10.1186/s13018-023-04111-x.

5:Progression to fusion after lumbar laminectomy for degenerative lumbar spondylolisthesis: Rate and risk-factors. A national database study.
Authors:Haider G, Varshneya K, Rodrigues A, Marianayagam N, Stienen MN, Veeravagu A
Institution:Department of Neurosurgery, Stanford University, Stanford, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address: ghanih@stanford.edu.
Journal:Clin Neurol Neurosurg. 2023 Oct;233:107919. doi: 10.1016/j.clineuro.2023.107919. Epub 2023 Jul 31.

6:Percutaneous transforaminal endoscopic surgery (PTES) and mini-incision L5/S1 OLIF with a self-lock cage for the surgical treatment of L5 spondylolisthesis.
Authors:Zhou T, Gu Y
Institution:Department of Orthopaedic Surgery, Zhongshan Hospital Fudan University, Shanghai, China. 447574313@qq.com.
Journal:J Orthop Surg Res. 2023 Jul 24;18(1):527. doi: 10.1186/s13018-023-04022-x.

7:Minimally invasive fusion surgery for patients with degenerative spondylolisthesis and severe lumbar spinal stenosis: a comparative study between MIDLIF and TLIF.
Authors:Silva PS, Jardim A, Pereira J, Sousa R, Vaz R, Pereira P
Institution:Spine Unit, Neurosurgery Department, Centro Hospitalar Universitario Sao Joao, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal. pedrodossantossilva@gmail.com.
Journal:Eur Spine J. 2023 Sep;32(9):3210-3217. doi: 10.1007/s00586-023-07847-6. Epub 2023 Jul 9.

8:Symptomatic lumbar stenosis due to low-grade degenerative spondylolisthesis can effectively be treated with mere decompression.
Authors:van Grafhorst JMP, Dijkerman ML, Peul WC, Vleggeert-Lankamp CLA
Institution:University Neurosurgical Center Holland, LUMC, HMC, HAGA, Leiden, the Netherlands. J.M.P.van_Grafhorst@lumc.nl.
Journal:Acta Neurochir (Wien). 2023 Aug;165(8):2145-2151. doi: 10.1007/s00701-023-05667-7. Epub 2023 Jul 6.

9:A systematic review and meta-analysis of risk factors for reoperation after degenerative lumbar spondylolisthesis surgery.
Authors:Chen Y, Zhou Y, Chen J, Luo Y, Wang Y, Fan X
Institution:Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, P.R. China.; Department of Orthopedics, Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shi-Er-Qiao Road, Jinniu District, Chengdu, 610075, P.R. China. drfxiaohong@163.com.
Journal:BMC Surg. 2023 Jul 5;23(1):192. doi: 10.1186/s12893-023-02082-8.

10:Instrumented Versus Uninstrumented Posterolateral Fusion for Lumbar Spondylolisthesis: A Randomized Controlled Trial.
Authors:Andresen AK, Wickstrøm LA, Holm RB, Carreon LY, Andersen MØ
Institution:Center for Spine Surgery and Research, Lillebaelt Hospital, Middelfart, Denmark.
Journal:J Bone Joint Surg Am. 2023 Sep 6;105(17):1309-1317. doi: 10.2106/JBJS.22.00941. Epub 2023 Jun 22.

11:Natural History of Degenerative Spondylolisthesis: A Systematic Review and Meta-analysis.
Authors:Atalay B, Gadjradj PS, Sommer FS, Wright D, Rawanduzy C, Ghogawala Z, Härtl R
Institution:Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital OCH SPINE, New York, New York, USA; Department of Neurological Surgery, Beth Israel Lahey Hospital and Medical Center, Tufts University School of Medicine, Burlington, Massachusetts, USA. Electronic address: drbasaratalay@gmail.com.; Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital OCH SPINE, New York, New York, USA.
Journal:World Neurosurg. 2023 Aug;176:e634-e643. doi: 10.1016/j.wneu.2023.05.112. Epub 2023 Jun 2.

12:Anterolateral versus posterior minimally invasive lumbar interbody fusion surgery for spondylolisthesis: comparison of outcomes from a global, multicenter study at 12-months follow-up.
Authors:Pereira P, Park Y, Arzoglou V, Charles YP, Krutko A, Senker W, Park SW, Franke J, Fuentes S, Bordon G, Song Y, He S, Vialle E, Mlyavykh S, Varanda P, Hosszu T, Bhagat S, Hong JY, Vanhauwaert D, de la Dehesa P
Institution:Centro Hospitalar Universitario Sao Joao, Faculty of Medicine, University of Porto, Portugal; Department of Neurosurgery, Hull and East Yorkshire Hospitals NHS Trust, Anlaby Rd, Hull HU3 2JZ, United Kingdom. Electronic address: pereira.paulom@gmail.com.; Department of Neurosurgery-Spine Unit, Hospital Marques de Valdecilla, Av. de Valdecilla, s/n, 39008 Santander, Cantabria, Spain.
Journal:Spine J. 2023 Oct;23(10):1494-1505. doi: 10.1016/j.spinee.2023.05.013. Epub 2023 May 25.

13:Full-endoscopic foraminotomy in low-grade degenerative and isthmic spondylolisthesis: a patient-specific tailored approach.
Authors:Van Isseldyk F, Liu Y, Kim JH, Correa C, Quillo-Olvera J, Kim JS
Institution:Department of Neurosurgery, Hospital Privado de Rosario, Rosario, Argentina.; Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-Gu, 06591, Seoul, South Korea. md1david@catholic.ac.kr.
Journal:Eur Spine J. 2023 Aug;32(8):2828-2844. doi: 10.1007/s00586-023-07737-x. Epub 2023 May 22.

14:Laminectomy With Fusion is Associated With Greater Functional Improvement Compared With Laminectomy Alone for the Treatment of Degenerative Lumbar Spondylolisthesis: A Systematic Review and Meta-Analysis.
Authors:Shukla GG, Chilakapati SS, Matur AV, Palmisciano P, Conteh F, Onyewadume L, Duah H, Griffith A, Tao X, Vorster P, Gupta S, Cheng J, Motley B, Adogwa O
Institution:Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH.
Journal:Spine (Phila Pa 1976). 2023 Jun 15;48(12):874-884. doi: 10.1097/BRS.0000000000004673. Epub 2023 Apr 6.

15:A novel less invasive endoscopic-assisted procedure for complete reduction of low-and high-grade isthmic spondylolisthesis performed by anterior and posterior combined approach.
Authors:Bassani R, Morselli C, Cirullo A, Pezzi A, Peretti GM
Institution:Spine Surgery II, IRCCS Ospedale Galeazzi Sant'Ambrogio, Via Cristina Belgioioso, 173, 20157, Milan, Italy.
Journal:Eur Spine J. 2023 Aug;32(8):2819-2827. doi: 10.1007/s00586-023-07666-9. Epub 2023 Mar 31.

16:Decompression alone versus decompression with instrumented fusion in the treatment of lumbar degenerative spondylolisthesis: a systematic review and meta-analysis of randomised trials.
Authors:Kaiser R, Kantorová L, Langaufová A, Slezáková S, Tučková D, Klugar M, Klézl Z, Barsa P, Cienciala J, Hajdúk R, Hrabálek L, Kučera R, Netuka D, Prýmek M, Repko M, Smrčka M, Štulík J
Institution:Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University, Prague, Czech Republic Radek.Kaiser@uvn.cz.; Department of Spinal Surgery, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Journal:J Neurol Neurosurg Psychiatry. 2023 Aug;94(8):657-666. doi: 10.1136/jnnp-2022-330158. Epub 2023 Feb 27.

17:Transforaminal Lumbar Interbody Fusion Versus Posterolateral Fusion Alone in the Treatment of Grade 1 Degenerative Spondylolisthesis.
Authors:Tang AR, Chanbour H, Steinle AM, Jonzzon S, Roth SG, Gardocki RJ, Stephens BF, Abtahi AM, Zuckerman SL
Institution:Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Journal:Neurosurgery. 2023 Jul 1;93(1):186-197. doi: 10.1227/neu.0000000000002402. Epub 2023 Feb 24.

18:Factors influencing the long-term outcomes of instrumentation surgery for degenerative lumbar spondylolisthesis: a post-hoc analysis of a prospective randomized study.
Authors:Inose H, Kato T, Matsukura Y, Hirai T, Yoshii T, Kawabata S, Takahashi K, Okawa A
Institution:Department of Orthopedic and Trauma Research, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. Electronic address: inose.orth@tmd.ac.jp.; Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
Journal:Spine J. 2023 Jun;23(6):799-804. doi: 10.1016/j.spinee.2023.02.002. Epub 2023 Feb 11.

19:Patient's expectations of surgery for lumbar degenerative spondylolisthesis: analysis by type of surgery and patient factors from the Canadian Spine Outcomes and Research Network (CSORN).
Authors:Dandurand C, Urquhart J, Bailey CS, Ailon T, Charest-Morin R, Dea N, Dvorak M, Glennie A, Kwon BK, Paquette S, Rampersaud YR, Street JT, Hounjet C, Mashayekhi MS, Fisher CG
Institution:Department of Orthopedics Surgery, Combined Neurosurgical and Orthopedic Spine Program, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: Charlotte.dandurand@vch.ca.
Journal:Spine J. 2023 Jun;23(6):805-815. doi: 10.1016/j.spinee.2023.01.018. Epub 2023 Feb 9.

20:Clinical outcome in decompression alone versus decompression and instrumented fusion in patients with isthmic spondylolisthesis: a prospective cohort study.
Authors:Azizpour K, Schutte PJ, Arts MP, Pondaag W, Bouma GJ, Coppes M, Steyerberg EW, Peul WC, Vleggeert-Lankamp CLA
Institution:1Department of Neurosurgery, Leiden University Medical Center, Leiden, Zuid-Holland.
Journal:J Neurosurg Spine. 2023 Feb 3;38(5):573-584. doi: 10.3171/2022.12.SPINE22808. Print 2023 May 1.

21:Surgical management of isthmic spondylolisthesis: A comparative study of postoperative outcomes between ALIF and TLIF.
Authors:Prost S, Giorgi H, Ould-Slimane M, Zairi F, Collinet A, D'astorg H, Szadkowski M, Litrico S, Gennari A, Grelat M, Parent H, Fuentes S, Charles YP, Blondel B
Institution:Aix-Marseille universite, AP-HM, CNRS, ISM, CHU Timone, unite de chirurgie rachidienne, 264, rue Saint-Pierre, 13005 Marseille, France. Electronic address: benjamin.blondel@ap-hm.fr.
Journal:Orthop Traumatol Surg Res. 2023 Oct;109(6):103560. doi: 10.1016/j.otsr.2023.103560. Epub 2023 Jan 23.

22:Decompression alone versus decompression with fusion in patients with lumbar spinal stenosis with degenerative spondylolisthesis: a systematic review and meta-analysis.
Authors:Gadjradj PS, Basilious M, Goldberg JL, Sommer F, Navarro-Ramirez R, Mykolajtchuk C, Ng AZ, Medary B, Hussain I, Härtl R
Institution:Department of Neurological Surgery, Brain and Spine Center, Weill Cornell, New York, NY, USA. p.gadjradj@erasmusmc.nl.
Journal:Eur Spine J. 2023 Mar;32(3):1054-1067. doi: 10.1007/s00586-022-07507-1. Epub 2023 Jan 6.

23:A Review of the Main Classifications of Lumbar Spondylolisthesis.
Authors:Lan Z, Yan J, Yang Y, Xu Q, Jin Q
Institution:Ningxia Medical University, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China; Orthopedics Ward 3, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. Electronic address: lzb360999@163.com.
Journal:World Neurosurg. 2023 Mar;171:94-102. doi: 10.1016/j.wneu.2022.12.104. Epub 2022 Dec 28.

24:Recent Efficacy of Oblique Lateral Interbody Fusion Combined With Wiltse Approach Pedicle Screw Fixation for Degenerative Single-Level Lumbar Spondylolisthesis.
Authors:Du W, Wang Z, Dong Y, Hu J, Quan R, Qi J
Institution:Research Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China. Electronic address: qijiwei3509@163.com.
Journal:World Neurosurg. 2023 Mar;171:e533-e541. doi: 10.1016/j.wneu.2022.12.051. Epub 2022 Dec 15.

25:Fusion and clinical outcomes of lumbar interbody fusion for low-grade isthmic spondylolisthesis.
Authors:Ould-Slimane M, Prost S, d'Astorg H, Lalevée M, Blondel B, Szadkowski M, Fuentes S, Collinet A, Parent HF, Litrico S, Grelat M, Zairi F, Charles YP, Giorgi H
Institution:Department of Orthopedic Surgery, Spine Unit, Rouen University Hospital, Rouen, France. Electronic address: mourad.ould-slimane@chu-rouen.fr.; Institut Mediterraneen du Dos, Marseille, France.
Journal:Orthop Traumatol Surg Res. 2023 Apr;109(2):103508. doi: 10.1016/j.otsr.2022.103508. Epub 2022 Dec 7.

26:Is Full-Endoscopic Transforaminal Lumbar Interbody Fusion Superior to Open Transforaminal Lumbar Interbody Fusion for Single-Level Degenerative Lumbar Spondylolisthesis? A Retrospective Study.
Authors:Yin J, Jiang X, Xu N, Nong L, Jiang Y
Institution:Department of Orthopedics, The Affiliated Changzhou No.2 People's Hospital with Nanjing Medical University, Changzhou, People's Republic of China.
Journal:J Neurol Surg A Cent Eur Neurosurg. 2024 Jan;85(1):39-47. doi: 10.1055/a-1994-7857. Epub 2022 Dec 8.

27:Surgical management of high-grade paediatric spondylolisthesis: meta-analysis and systematic review.
Authors:Koucheki R, Rocos B, Gandhi R, Lewis SJ, Lebel DE
Institution:Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. david.lebel@sickkids.ca.
Journal:Eur Spine J. 2023 Feb;32(2):436-446. doi: 10.1007/s00586-022-07408-3. Epub 2022 Oct 5.

28:High-grade dysplastic spondylolisthesis: surgical technique and case series.
Authors:Faldini C, Barile F, Ialuna M, Manzetti M, Viroli G, Vita F, Traversari M, Rinaldi A, Cerasoli T, Paolucci A, D'Antonio G, Ruffilli A
Institution:IRCCS Istituto Ortopedico Rizzoli, 1st Orthopaedics and Traumatology Clinic, University of Bologna, Bologna, Italy.
Journal:Musculoskelet Surg. 2023 Sep;107(3):323-331. doi: 10.1007/s12306-022-00763-w. Epub 2022 Oct 1.

29:To fuse or not to fuse: The elderly patient with lumbar stenosis and low-grade spondylolisthesis. Systematic review and meta-analysis of randomised controlled trials.
Authors:Abdel-Fattah AR, Bell F, Boden L, Ferry J, McCormick C, Ross M, Cameron I, Smith T, Baliga S, Myint PK
Institution:Ageing Clinical and Experimental Research (ACER) Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK.; Ageing Clinical and Experimental Research (ACER) Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK. Electronic address: phyo.myint@abdn.ac.uk.
Journal:Surgeon. 2023 Feb;21(1):e23-e31. doi: 10.1016/j.surge.2022.02.008. Epub 2022 Mar 16.

30:The Fate of Nonoperative Management in Patients with Lytic Spondylolisthesis.
Authors:Sinha S, George KJ
Institution:Manchester Medical School, University of Manchester, Manchester, United Kingdom.
Journal:J Neurol Surg A Cent Eur Neurosurg. 2023 Jul;84(4):355-359. doi: 10.1055/a-1747-9905. Epub 2022 Jan 21.

31:Changes in standing and walking time after multimodal physical rehabilitation in low grade degenerative lumbar spondylolisthesis: a non-randomised pilot study.
Authors:Jain S, Khanna K, Shetty GM, Linjhara S, Nene A, Ashar D, Ram CS
Institution:QI Spine Clinic, Dwarka, New Delhi, India.; Department of Physiotherapy, ITS College of Physiotherapy, Ghaziabad India.
Journal:Physiother Theory Pract. 2023 Apr;39(4):727-737. doi: 10.1080/09593985.2022.2025965. Epub 2022 Jan 13.

For a FREE PREVIEW of the Medifocus Guidebook on Spondylolisthesis click here

To purchase a copy of the COMPLETE Medifocus Guidebook on Spondylolisthesis click here

To subscribe to additional FREE Medifocus Digest Alert on other disease/condition areas click here

Get the Medifocus Guidebook on Spondylolisthesis...
at a Special 25% Discount

Medifocus Guidebook on Spondylolisthesis

Updated: January 11, 2024
114 Pages

This one of a kind Guidebook offers:

  • Answers to your critical health questions including the latest treatments, clinical trials, and expert research.
  • High Quality, Professional level information you can trust and understand culled from the latest peer-reviewed journals.
  • Timely, up to date content with free guidebook updates for 1 year.
  • A unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks.
  • Over 130,000 Guidebooks Sold
  • 100% Risk Free Money Back Guarantee


The Medifocus Guidebook on Spondylolisthesis is available in the following two convenient formats:


Soft-cover book that is available for immediate shipping via either U.S. Priority Mail or International AirMail (outside the U.S.).

  • Regular List Price = $39.95
  • Less 25% Discount = - $10.00
  • Discounted Price = $29.95(excluding shipping & handling)

Order the Printed Guidebook


Available for immediate download as a PDF document.

  • Regular List Price = $26.60
  • Less 25% Discount = - $6.65
  • Discounted Price = $19.95

Order the Digital Guidebook

Order by Phone

Call Toll Free in the U.S.

From Outside the U.S.

You can also receive a 25% discount when you order your Guidebook by phone.

To receive your 25% discount, simply mention the Discount Coupon Code below to the customer service representative taking your order.

Discount Coupon Code for
Phone Orders


Coupon Expires: August 22, 2024

What Our Customers Are Saying...

"The MediFocus Guidebook on Spondylolisthesis provided me with the information I needed to make an informed decision regarding my treatment. The Guidebook clearly explained the various grades of spondylolisthesis and what patients can expect at each stage. The various treatment options are also clearly explained so that you walk away with a much more realistic expectation about what to expect after treatment."
Shereveport, Louisiana

"The MediFocus Guidebook on Spondylolisthesis enabled me to have a more meaningful and serious discussion with my Orthopedic Surgeon about the various treatment options that are available to me. Your very comprehensive and informative Guidebook not only helped me prepare the right questions to ask my surgeon but also helped me better understand the answers he provided."
Plano, Texas

"Your MediFocus Guidebook on Spondylolisthesis helped me to prepare important questions to ask my doctors about the risks and complications associated with the proposed surgical solution to my low back problem. Thank you."
Malvern, Pennsylvania

Medifocus Digest Alert is published by Medifocus, Inc.
3809 Clarks Lane, Suite 100, Baltimore, MD 21215 USA
Copyright © 2024 Medifocus, Inc. All rights reserved.