Sjogren's Syndrome
January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Risk analysis of breast cancer and breast fibrocystic change in female primary Sjögren's syndrome patients.
Authors:Chen HY, Chung JY, Lin SC
Institution:Department of Pediatrics, Hsinchu Cathay General Hospital, Hsinchu, Taiwan.; School of Medicine, School of Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Journal:Medicine (Baltimore). 2023 Dec 22;102(51):e36769. doi: 10.1097/MD.0000000000036769.

2:Efficacy and safety of platelet-rich plasma and autologous-serum eye drops for dry eye in primary Sjögren's syndrome: a randomized trial.
Authors:Kang MJ, Lee JH, Hwang J, Chung SH
Institution:Department of Ophthalmology, College of Medicine, Sanggye Paik Hospital, Inje University, Seoul, Republic of Korea.; Department of Ophthalmology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Journal:Sci Rep. 2023 Nov 7;13(1):19279. doi: 10.1038/s41598-023-46671-2.

3:Sexual health in women with Sjogren's syndrome: A review.
Authors:Yang Y, Huang XX, Huo RX, Lin JY
Institution:Department of Rheumatology and Immunology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. Electronic address:
Journal:Eur J Obstet Gynecol Reprod Biol. 2023 Dec;291:1-9. doi: 10.1016/j.ejogrb.2023.09.025. Epub 2023 Sep 27.

4:Increased prevalences of head and neck cancers in patients with Sjögren's syndrome.
Authors:Yang TH, Cheng YF, Chen CS, Lin HC
Institution:Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.; School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan.
Journal:Head Neck. 2023 Nov;45(11):2874-2881. doi: 10.1002/hed.27518. Epub 2023 Sep 22.

5:Safety and Efficacy of Oral Hydroxychloroquine in the Treatment of Ophthalmic Disease Associated with Sjögren's Syndrome.
Authors:Fang W, Qingqing Z, Qihui L, Bing Z, Xinyue H, Jie X
Journal:Altern Ther Health Med. 2023 Nov;29(8):656-662.

6:Periodontitis in patients with primary Sjögren's syndrome: A nation-wide register study.
Authors:Aga OO, Bolstad AI, Lie SA, Svanes Fevang BT
Institution:Faculty of Medicine, University of Bergen, Bergen, Norway.
Journal:Eur J Oral Sci. 2023 Oct-Nov;131(5-6):e12950. doi: 10.1111/eos.12950. Epub 2023 Aug 31.

7:The risk of developing non-Hodgkin lymphoma and the mortality rate in primary Sjögren's syndrome: a single-centre, retrospective cohort study.
Authors:Mayer M, Martinic M, Reihl-Crnogaj M, Anic B
Institution:Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital Center Zagreb, 10000, Zagreb, Croatia.
Journal:Rheumatol Int. 2023 Nov;43(11):2031-2036. doi: 10.1007/s00296-023-05386-3. Epub 2023 Jul 25.

8:Emerging treatment for Sjögren's disease: a review of recent phase II and III trials.
Authors:Fox RI, Fox CM, McCoy SS
Institution:Rheumatology, Scripps Memorial Hospital and Research Foundation, San Diego, CA, USA.; University of Wisconsin-Madison, Madison, USA.
Journal:Expert Opin Emerg Drugs. 2023 Dec;28(2):107-120. doi: 10.1080/14728214.2023.2209720. Epub 2023 May 8.

9:Pathogenesis and treatment of Sjogren's syndrome: Review and update.
Authors:Zhan Q, Zhang J, Lin Y, Chen W, Fan X, Zhang D
Institution:State Key Laboratory of Biotherapy and Cancer Center, Department of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Journal:Front Immunol. 2023 Feb 2;14:1127417. doi: 10.3389/fimmu.2023.1127417. eCollection 2023.

10:Vitamin D and Sjögren's Disease: Revealing the Connections-A Systematic Review and Meta-Analysis.
Authors:Radić M, Kolak E, Đogaš H, Gelemanović A, Bučan Nenadić D, Vučković M, Radić J
Institution:Internal Medicine Department, Rheumatology, Allergology, and Clinical Immunology Division, University Hospital of Split, 21000 Split, Croatia.; Department of Internal Medicine, School of Medicine, University of Split, 21000 Split, Croatia.
Journal:Nutrients. 2023 Jan 18;15(3):497. doi: 10.3390/nu15030497.

11:Risk factors for primary Sjögren's Syndrome: a systematic review and meta-analysis.
Authors:Jin L, Dai M, Li C, Wang J, Wu B
Institution:Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, No. 6, Pan Xi Qi Zhi Road, Jiangbei District, Chongqing, 400021, China.
Journal:Clin Rheumatol. 2023 Feb;42(2):327-338. doi: 10.1007/s10067-022-06474-8. Epub 2022 Dec 19.

12:Phases and Natural History of Sjögren's Disease: A New Model for an Old Disease?
Authors:Lee AYS, Wang JJ, Gordon TP, Reed JH
Institution:The Westmead Institute for Medical Research, University of Sydney, Westmead Hospital, NSW Health Pathology, Westmead, New South Wales, Australia.; The Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Journal:Arthritis Care Res (Hoboken). 2023 Jul;75(7):1580-1587. doi: 10.1002/acr.25011. Epub 2023 Jan 5.

13:Lacripep for the Treatment of Primary Sjögren-Associated Ocular Surface Disease: Results of the First-In-Human Study.
Authors:Tauber J, Laurie GW, Parsons EC, Odrich MG
Institution:Tauber Eye Center, Kansas City, MO.; Departments of Cell Biology.
Journal:Cornea. 2023 Jul 1;42(7):847-857. doi: 10.1097/ICO.0000000000003091. Epub 2022 Jul 28.

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