January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Effect of various photobiomodulation regimens on breast cancer-related lymphedema: A systematic review and meta-analysis.
Authors:Chiu ST, Lai UH, Huang YC, Leong CP, Chen PC
Institution:Department of Physical Medicine and Rehabilitation, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.
Journal:Lasers Med Sci. 2023 Dec 22;39(1):11. doi: 10.1007/s10103-023-03959-z.

2:Effectiveness of manual lymphatic drainage in intensive phase I therapy of breast cancer-related lymphedema-a retrospective analysis.
Authors:Kasseroller RG, Brenner E
Institution:Bad Vigaun Medical Centre, Karl-Rodhammer-Weg 91, 5424, Bad Vigaun, Salzburg, Austria.; Institute for Clinical and Functional Anatomy, Medical University of Innsbruck, Mullerstrasse 59, 6020, Innsbruck, Austria.
Journal:Support Care Cancer. 2023 Dec 5;32(1):5. doi: 10.1007/s00520-023-08210-7.

3:Can Acupuncture be a Part of the Treatment for Breast Cancer-Related Lymphedema? A Systematic Review of the Safety and Proposed Model for Care.
Authors:Kim JK, Loo C, Kim JS, Pranskevich C, Gordon OK
Institution:Disney Family Cancer Center, Providence St Joseph Medical Center, Burbank, CA, USA.
Journal:Lymphology. 2023;56(1):27-39.

4:Imaging Modalities for Evaluating Lymphedema.
Authors:Nagy BI, Mohos B, Tzou CJ
Institution:Department of Thoracic, Cardiac and Vascular Surgery, Westpfalz-Klinikum GmbH, 67655 Kaiserslautern, Germany.; Plastic and Reconstructive Surgery, Department of Surgery, Hospital of Divine Savior, 1060 Vienna, Austria.
Journal:Medicina (Kaunas). 2023 Nov 16;59(11):2016. doi: 10.3390/medicina59112016.

5:Effectiveness of manual lymphatic drainage and intermittent pneumatic compression in lymphedema maintenance therapy.
Authors:Mendoza E, Amsler F
Institution:Venenpraxis Wunstorf, Germany.; Amsler Consulting, Basel, Switzerland.
Journal:Vasa. 2023 Nov;52(6):423-431. doi: 10.1024/0301-1526/a001090. Epub 2023 Oct 16.

6:Managing the Morbidity: Individualizing Risk Assessment, Diagnosis, and Treatment Options for Upper Extremity Lymphedema.
Authors:Montagna G, Barrio AV
Institution:Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY 10065, USA. Electronic address:
Journal:Surg Oncol Clin N Am. 2023 Oct;32(4):705-724. doi: 10.1016/j.soc.2023.05.004. Epub 2023 Jun 25.

7:Conservative treatment versus lymphaticovenular anastomosis for early-stage lower extremity lymphedema.
Authors:Shimbo K, Kawamoto H, Koshima I
Institution:Department of Plastic and Reconstructive Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan. Electronic address:; Department of Plastic and Reconstructive Surgery, Hiroshima University Hospital, Hiroshima, Japan; International Center for Lymphedema, Hiroshima University Hospital, Hiroshima, Japan.
Journal:J Vasc Surg Venous Lymphat Disord. 2023 Nov;11(6):1231-1240. doi: 10.1016/j.jvsv.2023.06.013. Epub 2023 Jul 16.

8:Current Concepts in the Management of Primary Lymphedema.
Authors:Senger JB, Kadle RL, Skoracki RJ
Institution:Wexner Medical Center, Department of Plastic Surgery, Ohio State University, Columbus, OH 43210, USA.
Journal:Medicina (Kaunas). 2023 May 6;59(5):894. doi: 10.3390/medicina59050894.

9:Diagnosis and Treatment of Post-Prostatectomy Lymphedema: What's New?
Authors:Bianchi LMG, Irmici G, Cè M, D'Ascoli E, Della Pepa G, Di Vita F, Casati O, Soresina M, Menozzi A, Khenkina N, Cellina M
Institution:Postgraduation School in Radiodiagnostics, University of Milan, 20122 Milan, Italy.; Radiology Department, Fatebenefratelli Hospital, ASST Fatebenefratelli Sacco, 20121 Milan, Italy.
Journal:Curr Oncol. 2023 Apr 25;30(5):4512-4526. doi: 10.3390/curroncol30050341.

10:Impact on Health-Related quality of life after wearing compression garment or not for six months in women with mild breast cancer-related arm lymphedema. A cross-sectional study.
Authors:Blom KY, Johansson KI, Nilsson-Wikmar LB, Klernäs PE, Brogårdh CB
Institution:Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
Journal:Acta Oncol. 2023 May;62(5):528-534. doi: 10.1080/0284186X.2023.2213442. Epub 2023 May 21.

11:Advances in the prevention and treatment of breast cancer-related lymphedema.
Authors:Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Institution:Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, 2201 21St Children's Way, Suite 1218, Nashville, TN, 37212, USA.; Faculty of Medicine, Health, and Human Sciences, Australian Lymphoedema Education, Research, and Treatment (ALERT), Macquarie University, Sydney, Australia.
Journal:Breast Cancer Res Treat. 2023 Jul;200(1):1-14. doi: 10.1007/s10549-023-06947-7. Epub 2023 Apr 27.

12:Body mass index increases the risk of breast cancer-related lymphedema at 6-18 months after surgery: a retrospective study.
Authors:Wang L, Chen H, Li Y, Wang H, Liu N, Yu M, Shang S
Institution:School of Nursing, Wannan Medical College, Wuhu, 241002, China.; School of Nursing, Peking University, Haidian District, 38 Xueyuan Road, Beijing, 100191, China.
Journal:Support Care Cancer. 2023 Apr 19;31(5):278. doi: 10.1007/s00520-023-07721-7.

13:Outcomes after microsurgical treatment of lymphedema: a systematic review and meta-analysis.
Authors:Meuli JN, Guiotto M, Elmers J, Mazzolai L, di Summa PG
Institution:Department of Plastic and Hand Surgery.
Journal:Int J Surg. 2023 May 1;109(5):1360-1372. doi: 10.1097/JS9.0000000000000210.

14:Practice patterns of physical therapists and physical therapist assistants treating patients with breast cancer related lymphedema.
Authors:Wampler M, Campione E, Bolch CA
Institution:Program in Physical Therapy, Oregon State University-Cascades, 1500 SW Chandler Ave., Bend, OR, 97702, USA.; Office of Research and Sponsored Programs, Midwestern University, 19555 N 59th Ave., Glendale, AZ, 85308, USA.
Journal:Support Care Cancer. 2023 Jan 26;31(2):134. doi: 10.1007/s00520-023-07589-7.

15:Association between Immediate Breast Reconstruction and the Development of Breast Cancer-Related Lymphedema.
Authors:Jeon HB, Jung JH, Im SH, Kim YB, Chang JS, Song SY, Lew DH, Roh TS, Lee WJ, Lee DW
Institution:From the Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration.
Journal:Plast Reconstr Surg. 2023 Feb 1;151(2):214e-222e. doi: 10.1097/PRS.0000000000009831. Epub 2022 Nov 8.

16:Current Diagnostic Tools for Breast Cancer-Related Lymphedema.
Authors:Shah C, Asha W, Vicini F
Institution:Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 10201 Carnegie Avenue, Cleveland, OH, 44106, USA.; GenesisCare, Farmington Hills, MI, USA.
Journal:Curr Oncol Rep. 2023 Mar;25(3):151-154. doi: 10.1007/s11912-023-01357-w. Epub 2023 Jan 25.

17:What do we know about treating breast-cancer-related lymphedema? Review of the current knowledge about therapeutic options.
Authors:Anuszkiewicz K, Jankau J, Kur M
Institution:Department of Plastic Surgery, Faculty of Medicine, Medical University of Gda?sk, 80-214, Gda?sk, Poland.
Journal:Breast Cancer. 2023 Mar;30(2):187-199. doi: 10.1007/s12282-022-01428-z. Epub 2022 Dec 26.

18:The breast cancer-related lymphedema multidisciplinary approach: Algorithm for conservative and multimodal surgical treatment.
Authors:Ciudad P, Bolletta A, Kaciulyte J, Losco L, Manrique OJ, Cigna E, Mayer HF, Escandón JM
Institution:Department of Plastic, Reconstructive and Burn Surgery, Arzobispo Loayza National Hospital, Lima, Peru.; Division of Plastic and Reconstructive Surgery, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, New York, USA.
Journal:Microsurgery. 2023 Jul;43(5):427-436. doi: 10.1002/micr.30990. Epub 2022 Nov 26.

19:Patient education for breast cancer-related lymphedema: a systematic review.
Authors:Perdomo M, Davies C, Levenhagen K, Ryans K, Gilchrist L
Institution:Division of Biokinesiology and Physical Therapy @ the Ostrow School of Dentistry, University of Southern California, 1540 Alcazar Street CHP 155, Los Angeles, CA, 90089, USA.; St. Catherine Univeristy, Doctor of Physical Therapy Program, 2004 Randolph Ave, St. Paul, MN, 55105, USA.
Journal:J Cancer Surviv. 2023 Apr;17(2):384-398. doi: 10.1007/s11764-022-01262-4. Epub 2022 Oct 8.

20:Evaluation of Sleep Quality, Depression, and Quality of Life in Patients with Breast Cancer Related Lymphedema.
Authors:Mete Civelek G, Akinci MG, Dalyan M
Institution:Department of Physical Medicine and Rehabilitation, Health Science University, Ankara City Hospital, Physical Therapy and Rehabilitation Hospital, Ankara, Turkey.
Journal:Lymphat Res Biol. 2023 Jun;21(3):289-295. doi: 10.1089/lrb.2022.0031. Epub 2022 Sep 29.

21:Risk factors for arm lymphedema following breast cancer surgery: a Japanese nationwide database study of 84,022 patients.
Authors:Konishi T, Tanabe M, Michihata N, Matsui H, Nishioka K, Fushimi K, Seto Y, Yasunaga H
Institution:Department of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.; Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Journal:Breast Cancer. 2023 Jan;30(1):36-45. doi: 10.1007/s12282-022-01395-5. Epub 2022 Aug 23.

22:Water-based exercise for upper and lower limb lymphedema treatment.
Authors:Maccarone MC, Venturini E, Menegatti E, Gianesini S, Masiero S
Institution:Physical Medicine and Rehabilitation School, University of Padua, Padua, Italy. Electronic address:; Physical Medicine and Rehabilitation School, University of Padua, Padua, Italy; Rehabilitation Unit, Department of Neuroscience, University of Padua, Padua, Italy.
Journal:J Vasc Surg Venous Lymphat Disord. 2023 Jan;11(1):201-209. doi: 10.1016/j.jvsv.2022.08.002. Epub 2022 Aug 20.

23:Effect of Manual Lymphatic Drainage on Breast Cancer-Related Postmastectomy Lymphedema: A Meta-analysis of Randomized Controlled Trials.
Authors:Qiao J, Yang LN, Kong YH, Huang X, Li Y, Bai DQ
Institution:Author Affiliations: Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University, China.
Journal:Cancer Nurs. 2023 Mar-Apr 01;46(2):159-166. doi: 10.1097/NCC.0000000000001061. Epub 2022 Mar 25.

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