July 2023 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Night-time compression: a valuable addition to the lymphoedema management toolkit.
Authors:Ramadan F
Institution:Freelance health writer.
Journal:Br J Community Nurs. 2023 Jun 2;28(6):293-296. doi: 10.12968/bjcn.2023.28.6.293.

2:Investigation of physical activity, fear of falling, and functionality in individuals with lower extremity lymphedema.
Authors:Pirincci CS, Cihan E, Ünüvar BS, Gerçek H, Aytar A, Borman P
Institution:Gulhane Faculty of Physiotherapy and Rehabilitation, University of Health Sciences, Ankara, Turkey.; Department of Physical Medicine and Rehabilitation, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.
Journal:Support Care Cancer. 2023 May 29;31(6):360. doi: 10.1007/s00520-023-07825-0.

3:Current Concepts in the Management of Primary Lymphedema.
Authors:Senger JB, Kadle RL, Skoracki RJ
Institution:Wexner Medical Center, Department of Plastic Surgery, Ohio State University, Columbus, OH 43210, USA.
Journal:Medicina (Kaunas). 2023 May 6;59(5):894. doi: 10.3390/medicina59050894.

4:Effects of Tuina Combined With Moxibustion on Breast Cancer-Related Lymphedema: A Randomized Cross-Over Controlled Trial.
Authors:Wang C, Liu H, Shen J, Hao Y, Zhao L, Fan Y, Pei X
Institution:Fangshan Hospital, Beijing University of Chinese Medicine, Beijing, China.; Xiamen Hospital, Beijing University of Chinese Medicine, Xiamen, Fujian Province, China.
Journal:Integr Cancer Ther. 2023 Jan-Dec;22:15347354231172735. doi: 10.1177/15347354231172735.

5:Advances in the prevention and treatment of breast cancer-related lymphedema.
Authors:Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Institution:Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, 2201 21St Children's Way, Suite 1218, Nashville, TN, 37212, USA.; Faculty of Medicine, Health, and Human Sciences, Australian Lymphoedema Education, Research, and Treatment (ALERT), Macquarie University, Sydney, Australia.
Journal:Breast Cancer Res Treat. 2023 Jul;200(1):1-14. doi: 10.1007/s10549-023-06947-7. Epub 2023 Apr 27.

6:Risk factors for the development of severe breast cancer-related lymphedema: a retrospective cohort study.
Authors:Liu X, Sun K, Yang H, Xia L, Lu K, Meng X, Li Y
Institution:General Surgery, Cancer center, Department of Breast Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014, Zhejiang, China.
Journal:BMC Cancer. 2023 Apr 20;23(1):361. doi: 10.1186/s12885-023-10814-5.

7:Outcomes after microsurgical treatment of lymphedema: a systematic review and meta-analysis.
Authors:Meuli JN, Guiotto M, Elmers J, Mazzolai L, di Summa PG
Institution:Department of Plastic and Hand Surgery.
Journal:Int J Surg. 2023 May 1;109(5):1360-1372. doi: 10.1097/JS9.0000000000000210.

8:Skin care protocol: suggesting a routine.
Authors:Hobday A
Institution:Deputy Head of Department, Department of Pre-Registration Nursing; Course Lead, BSc Nursing (Joint appointment); Principal Lecturer, Primary/Community Care; Teacher member, Casley-Smith Lymphoedema Education UK; Three Counties School of Nursing and Midwifery, College of Health, Life and Environmental Sciences, University of Worcester.
Journal:Br J Community Nurs. 2023 Apr 1;28(Sup4):S12-S14. doi: 10.12968/bjcn.2023.28.Sup4.S12.

9:The influence of axillary surgery and radiotherapeutic strategy on the risk of lymphedema and upper extremity dysfunction in early breast cancer patients.
Authors:Zheng SY, Chen CY, Qi WX, Cai G, Xu C, Cai R, Qian XF, Shen KW, Cao L, Chen JY
Institution:Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:
Journal:Breast. 2023 Apr;68:142-148. doi: 10.1016/j.breast.2023.02.001. Epub 2023 Feb 4.

10:A systematic review of validated assessments methods for head and neck lymphedema.
Authors:Arends CR, Lindhout JE, van der Molen L, Wilthagen EA, van den Brekel MWM, Stuiver MM
Institution:Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Journal:Eur Arch Otorhinolaryngol. 2023 Jun;280(6):2653-2661. doi: 10.1007/s00405-023-07841-0. Epub 2023 Feb 10.

11:Current Diagnostic Tools for Breast Cancer-Related Lymphedema.
Authors:Shah C, Asha W, Vicini F
Institution:Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 10201 Carnegie Avenue, Cleveland, OH, 44106, USA.; GenesisCare, Farmington Hills, MI, USA.
Journal:Curr Oncol Rep. 2023 Mar;25(3):151-154. doi: 10.1007/s11912-023-01357-w. Epub 2023 Jan 25.

12:Selecting appropriate compression for lymphedema patients: American Vein and Lymphatic Society position statement.
Authors:Hettrick H, Ehmann S, McKeown B, Bender D, Blebea J
Institution:College of Health Care Sciences, 2814Nova Southeastern University, Ft. Lauderdale FL, USA.; Department of Surgery, 367854Central Michigan University College of Medicine, Saginaw, MI, USA.
Journal:Phlebology. 2023 Mar;38(2):115-118. doi: 10.1177/02683555221149619. Epub 2023 Jan 6.

13:What do we know about treating breast-cancer-related lymphedema? Review of the current knowledge about therapeutic options.
Authors:Anuszkiewicz K, Jankau J, Kur M
Institution:Department of Plastic Surgery, Faculty of Medicine, Medical University of Gda?sk, 80-214, Gda?sk, Poland.
Journal:Breast Cancer. 2023 Mar;30(2):187-199. doi: 10.1007/s12282-022-01428-z. Epub 2022 Dec 26.

14:Risk factors for lower extremity lymphedema after surgery in cervical and endometrial cancer.
Authors:Lee J, Byun HK, Im SH, Son WJ, Roh YH, Kim YB
Institution:Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Journal:J Gynecol Oncol. 2023 May;34(3):e28. doi: 10.3802/jgo.2023.34.e28. Epub 2022 Dec 19.

15:Clinical Impact of Severe Obesity in Patients with Lymphoedema.
Authors:Labropoulos N, Raiker A, Gasparis A, Weycker D, O'Donnell T Jr
Institution:Department of Surgery, Stony Brook University Medical Centre, NY, USA. Electronic address:; Cardiovascular Centre at Tufts Medical Centre, Boston MA, USA.
Journal:Eur J Vasc Endovasc Surg. 2023 Mar;65(3):406-413. doi: 10.1016/j.ejvs.2022.11.014. Epub 2022 Nov 17.

16:Transcutaneous Electrical Acupoint Stimulation Combined with Warm Acupuncture for Breast Cancer Related Upper Limb Lymphedema: A Retrospective Cohort Study.
Authors:Lu C, Li GL, Deng DH, Bao WL, Wang Y, Zhang AQ
Institution:Department of Traditional Chinese Medicine, the Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310022, China.
Journal:Chin J Integr Med. 2023 Jun;29(6):534-539. doi: 10.1007/s11655-022-3684-7. Epub 2022 Nov 14.

17:Combining reconstructive and ablative surgical treatment of chronic breast cancer-related lymphedema (BCRL): safe and effective.
Authors:Ghazaleh AA, Handschin TM, Buckowiecki J, Chammartin FS, Andree C, Schaefer DJ, Haug M, Kappos EA, Seidenstuecker K
Institution:Department of Plastic, Reconstructive and Aesthetic Surgery, Sana Hospital Benrath, Duesseldorf, Germany.
Journal:Breast Cancer Res Treat. 2023 Jan;197(1):83-92. doi: 10.1007/s10549-022-06778-y. Epub 2022 Oct 26.

18:Patient education for breast cancer-related lymphedema: a systematic review.
Authors:Perdomo M, Davies C, Levenhagen K, Ryans K, Gilchrist L
Institution:Division of Biokinesiology and Physical Therapy @ the Ostrow School of Dentistry, University of Southern California, 1540 Alcazar Street CHP 155, Los Angeles, CA, 90089, USA.; St. Catherine Univeristy, Doctor of Physical Therapy Program, 2004 Randolph Ave, St. Paul, MN, 55105, USA.
Journal:J Cancer Surviv. 2023 Apr;17(2):384-398. doi: 10.1007/s11764-022-01262-4. Epub 2022 Oct 8.

19:Risk Factors Associated with Adverse Outcomes after Ablative Surgery for Lymphedema.
Authors:Kuruvilla AS, Shroyer ALW, Li X, Yang J, Mulay SR, Agha SM, Bellis RM, Kohli HK, Tannous HJ, Krajewski A
Institution:Division of Plastic Surgery, Department of Surgery, Stony Brook University, Renaissance School of Medicine, Stony Brook, New York.
Journal:J Reconstr Microsurg. 2023 Mar;39(3):214-220. doi: 10.1055/s-0042-1755258. Epub 2022 Sep 26.

20:Water-based exercise for upper and lower limb lymphedema treatment.
Authors:Maccarone MC, Venturini E, Menegatti E, Gianesini S, Masiero S
Institution:Physical Medicine and Rehabilitation School, University of Padua, Padua, Italy. Electronic address:; Physical Medicine and Rehabilitation School, University of Padua, Padua, Italy; Rehabilitation Unit, Department of Neuroscience, University of Padua, Padua, Italy.
Journal:J Vasc Surg Venous Lymphat Disord. 2023 Jan;11(1):201-209. doi: 10.1016/j.jvsv.2022.08.002. Epub 2022 Aug 20.

21:Factors Influencing Lower Limb Lymphedema After Cervical Cancer Surgery: A Case-Control Study.
Authors:Liu G, Hu J, Liu Y, Yuan M
Institution:Department of Lymphedema Rehabilitation, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P.R. China.
Journal:Lymphat Res Biol. 2023 Apr;21(2):169-178. doi: 10.1089/lrb.2022.0025. Epub 2022 Jul 29.

22:Breast cancer-related lymphoedema and resistance exercise: An evidence-based review of guidelines, consensus statements and systematic reviews.
Authors:Wang L, Shi YX, Wang TT, Chen KX, Shang SM
Institution:School of Nursing, Peking University, Beijing, China.
Journal:J Clin Nurs. 2023 May;32(9-10):2208-2227. doi: 10.1111/jocn.16437. Epub 2022 Jul 27.

23:The impact of rehabilitation sport on breast cancer-related lymphoedema and quality of life.
Authors:Boeer B, Seller A, Schoenfisch B, Krainick-Strobel U, Dietrich A, Brucker SY, Wallwiener D, Niess A, Hahn M
Institution:Department of Women's Health, University Hospital of Tuebingen, Calwerstrasse 7, 72076, Tuebingen, Germany.
Journal:Arch Gynecol Obstet. 2023 May;307(5):1529-1537. doi: 10.1007/s00404-022-06609-x. Epub 2022 Jul 26.

24:Experiences of breast cancer survivors with lymphedema self-management: a systematic review of qualitative studies.
Authors:Fu X, Lu Q, Pang D, Shen A, Shih YA, Wei X
Institution:Peking University School of Nursing, Beijing, China.
Journal:J Cancer Surviv. 2023 Jun;17(3):619-633. doi: 10.1007/s11764-022-01225-9. Epub 2022 Jun 30.

25:What Should We Focus on When Managing Breast Cancer-Related Lymphedema to Improve Quality of Life?
Authors:Lee HS, Lee HJ, Seo KS
Institution:Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Jongno-Gu, Seoul, Korea.
Journal:Lymphat Res Biol. 2023 Feb;21(1):28-33. doi: 10.1089/lrb.2021.0009. Epub 2022 Jun 10.

26:A comparative study between deep inferior epigastric artery perforator flap breast reconstruction and DIEP flap breast reconstruction coupled with vascularized lymph node transfer: Improving the quality of life of patients with breast cancer related lymphedema without affecting donor site outcomes.
Authors:Di Taranto G, Coleman GJ, Hardwicke J, Wallis KL, Skillman J
Institution:Department of Plastic Surgery, University Hospitals of Coventry and Warwickshire, Coventry, UK.
Journal:Microsurgery. 2023 Mar;43(3):213-221. doi: 10.1002/micr.30924. Epub 2022 May 30.

27:Effect of Manual Lymphatic Drainage on Breast Cancer-Related Postmastectomy Lymphedema: A Meta-analysis of Randomized Controlled Trials.
Authors:Qiao J, Yang LN, Kong YH, Huang X, Li Y, Bai DQ
Institution:Author Affiliations: Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University, China.
Journal:Cancer Nurs. 2023 Mar-Apr 01;46(2):159-166. doi: 10.1097/NCC.0000000000001061. Epub 2022 Mar 25.

28:Treatment of multiple limb lymphedema with combined supermicrosurgical techniques.
Authors:Chu CK, Hanasono MM, Chang EI
Institution:Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Journal:Microsurgery. 2023 Jan;43(1):13-19. doi: 10.1002/micr.30878. Epub 2022 Mar 4.

29:Guidelines Relevant to Diagnosis, Assessment, and Management of Lymphedema: A Systematic Review.
Authors:Torgbenu E, Luckett T, Buhagiar MA, Phillips JL
Institution:Improving Palliative, Aged and Chronic Care through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, Australia.
Journal:Adv Wound Care (New Rochelle). 2023 Jan;12(1):15-27. doi: 10.1089/wound.2021.0149. Epub 2022 Apr 6.

30:Modified Combined Physiological and Debulking Procedure for Lower Limb Lymphedema to Achieve Both Immediate and Sustained Results in Lymphedema.
Authors:Mir MA, Mahakalkar SS, Rashim M
Institution:442339All India Institute of Medical Sciences (AIIMS), Rishikesh, India.
Journal:Int J Low Extrem Wounds. 2023 Mar;22(1):194-199. doi: 10.1177/15347346211002367. Epub 2021 Apr 21.

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