March 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Physical therapy enhances functions and quality of life in older patients with breast cancer-related lymphedema: A prospective experimental study.
Authors:Kostanoglu A, Tarakcı E
Institution:Division of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bezmialem Vakif University, Turkey. Division of Neurologic Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul University-Cerrahpasa, Turkey.
Journal:Niger J Clin Pract. 2021 Mar;24(3):387-392. doi: 10.4103/njcp.njcp_373_19.

2:Guidelines for managing people with lymphoedema remotely: a post-COVID-19 response document.
Authors:Noble-Jones R, Thomas MJ, Lawrence P, Pike C
Institution:National Lymphoedema Researcher, Lymphoedema Network Wales. National Macmillan Lymphoedema Specialist, Swansea Bay University Health Board and Lymphoedema Network Wales.
Journal:Br J Nurs. 2021 Feb 25;30(4):218-225. doi: 10.12968/bjon.2021.30.4.218.

3:The Role of Body Mass Index in Breast Cancer-Associated Lymphedema.
Authors:Rockson SG
Institution:Lymphatic Research and Biology, Stanford University School of Medicine, Stanford, California, USA.
Journal:Lymphat Res Biol. 2020 Dec;18(6):501. doi: 10.1089/

4:Younger Age as a Risk Factor for Gynecologic Cancer-related Lymphedema: A Systematic Review.
Authors:Guliyeva G, Huayllani MT, Avila FR, Boczar D, Lu X, Forte AJ
Institution:Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, U.S.A.
Journal:Anticancer Res. 2020 Dec;40(12):6609-6612. doi: 10.21873/anticanres.14685.

5:Manual lymphatic drainage for lymphedema in patients after breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
Authors:Liang M, Chen Q, Peng K, Deng L, He L, Hou Y, Zhang Y, Guo J, Mei Z, Li L
Institution:Clinical Nursing Teaching and Research Section, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province.
Journal:Medicine (Baltimore). 2020 Dec 4;99(49):e23192. doi: 10.1097/MD.0000000000023192.

6:Efficacy and efficiency of a new therapeutic approach based on activity-oriented proprioceptive antiedema therapy (TAPA) for edema reduction and improved occupational performance in the rehabilitation of breast cancer-related arm lymphedema in women: a controlled, randomized clinical trial.
Authors:Muñoz-Alcaraz MN, Pérula-de-Torres LÁ, Serrano-Merino J, Jiménez-Vílchez AJ, Olmo-Carmona MV, Muñoz-García MT, Bartolomé-Moreno C, Oliván-Blázquez B, Magallón-Botaya R
Institution:Cordoba and Guadalquivir health district, Andalusia Health Service, Cordoba, Spain. Institute for Health Research Aragon (IIS Aragon), Zaragoza, Spain.
Journal:BMC Cancer. 2020 Nov 9;20(1):1074. doi: 10.1186/s12885-020-07558-x.

7:Effects of 12 weeks of water aerobics on body composition in those affected by breast cancer.
Authors:Salacinski AJ, Doyle EJ, Damon R, Acevedo RA, Broeder CE
Institution:Department of Movement, Sport and Leisure Studies, Westfield State University, Woodward Center 215, Westfield, MA, 01086, USA. Exercising Nutritionally, LLC, Lisle, IL, USA.
Journal:Support Care Cancer. 2021 Mar;29(3):1205-1212. doi: 10.1007/s00520-020-05596-6. Epub 2020 Jul 1.

8:Advanced pneumatic compression for treatment of lymphedema of the head and neck: a randomized wait-list controlled trial.
Authors:Ridner SH, Dietrich MS, Deng J, Ettema SL, Murphy B
Institution:Vanderbilt School of Nursing, Vanderbilt University School of Nursing, 461 21st Avenue South, Nashville, TN, 37240, USA. Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN, 37232, USA.
Journal:Support Care Cancer. 2021 Feb;29(2):795-803. doi: 10.1007/s00520-020-05540-8. Epub 2020 Jun 2.

9:Deep Inferior Epigastric Artery Vascularized Lymph Node Transfer: A Simple and Safe Option for Lymphedema.
Authors:Hassanein AH, Danforth R, DeBrock W, Mailey B, Lester M, Socas J
Institution:Division of Plastic Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:
Journal:J Plast Reconstr Aesthet Surg. 2020 Oct;73(10):1897-1916. doi: 10.1016/j.bjps.2020.03.017. Epub 2020 May 14.

10:Incidence and predictors of axillary web syndrome and its association with lymphedema in women following breast cancer treatment: a retrospective study.
Authors:Ryans K, Davies CC, Gaw G, Lambe C, Henninge M, VanHoose L
Institution:Department of Physical Therapy, Mercy College, Dobbs Ferry, NY, USA. Department of Physical Therapy, University of Louisiana Monroe, Monroe, LA, USA.
Journal:Support Care Cancer. 2020 Dec;28(12):5881-5888. doi: 10.1007/s00520-020-05424-x. Epub 2020 Apr 8.

11:Physical activity level and age contribute to functioning problems in patients with breast cancer-related lymphedema: a multicentre cross-sectional study.
Authors:De Vrieze T, Gebruers N, Nevelsteen I, Tjalma WAA, Thomis S, De Groef A, Dams L, Van der Gucht E, Devoogdt N
Institution:Department of Rehabilitation Sciences, KU Leuven, University of Leuven, Leuven, Belgium.
Journal:Support Care Cancer. 2020 Dec;28(12):5717-5731. doi: 10.1007/s00520-020-05375-3. Epub 2020 Mar 19.

12:Low-Intensity Resistance Training and Compression Garment in the Management of Breast Cancer-Related Lymphedema: Single-Blinded Randomized Controlled Trial.
Authors:Omar MTA, Gwada RFM, Omar GSM, El-Sabagh RM, Mersal AAE
Institution:Physical Therapy Department for Surgery, Faculty of Physical Therapy, Cairo University, 7 Ahmad Al-Zayat St., Bain El-Sarayat, Giza, 12612, Egypt. Surgery Department, El-Mattaria Teaching Hospital, Cairo, Egypt.
Journal:J Cancer Educ. 2020 Dec;35(6):1101-1110. doi: 10.1007/s13187-019-01564-9.

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