Peripheral Neuropathy
July 2023 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Peripheral Neuropathy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Peripheral Neuropathy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Peripheral Neuropathy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Peripheral Neuropathy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Analysis of Factors Related to Type 2 Diabetic Peripheral Neuropathy Based on Flash Glucose Monitoring System.
Authors:Ma Q
Institution:Community General Practitioner's Office, Community Health Service Center of Beitang Street, Binhai New Arae, Tianjin, China (mainland).
Journal:Med Sci Monit. 2023 Jun 8;29:e939157. doi: 10.12659/MSM.939157.

2:A randomized, active-controlled, parallel, open-label, multicenter, phase 4 study to compare the efficacy and safety of pregabalin sustained release tablet and pregabalin immediate release capsule in type II diabetic patients with peripheral neuropathic pain.
Authors:Kang SM, Hong JH, Ku BJ
Institution:Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, South Korea.; Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, South Korea.
Journal:Medicine (Baltimore). 2023 Apr 25;102(17):e33701. doi: 10.1097/MD.0000000000033701.

3:Persistent weekly paclitaxel-induced peripheral neuropathy in early breast cancer patients enrolled in a randomized trial of cryotherapy.
Authors:Shigematsu H, Kimura Y, Itagaki T, Yasui D
Institution:Department of Breast Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1, Aoyama-cho, Kure-City, Hiroshima 737-0023, Japan.
Journal:Medicine (Baltimore). 2023 Apr 21;102(16):e33580. doi: 10.1097/MD.0000000000033580.

4:Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral Neuropathy.
Authors:D'Souza RS, Alvarez GAM, Dombovy-Johnson M, Eller J, Abd-Elsayed A
Institution:Department of Anesthesiology and Perioperative Medicine, Mayo Clinic Hospital, Rochester, MN, USA.; Department of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Journal:Curr Pain Headache Rep. 2023 May;27(5):99-116. doi: 10.1007/s11916-023-01107-4. Epub 2023 Apr 14.

5:Peripheral Neuropathy in Older People Is Associated with Reduced Life Expectancy.
Authors:Lawler FH, Mold JW, Liao X, Bard DE
Institution:From the Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (FHL, JWM); Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City (XL, DEB).
Journal:J Am Board Fam Med. 2023 May 8;36(3):431-438. doi: 10.3122/jabfm.2022.220306R1. Epub 2023 Apr 7.

6:Case Series of Acute Peripheral Neuropathies in Individuals Who Received COVID-19 Vaccination.
Authors:Sukockienė E, Breville G, Fayolle D, Nencha U, Uginet M, Hübers A
Institution:Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals, 1205 Geneva, Switzerland.
Journal:Medicina (Kaunas). 2023 Mar 3;59(3):501. doi: 10.3390/medicina59030501.

7:Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis.
Authors:Nuñez de Arenas-Arroyo S, Cavero-Redondo I, Torres-Costoso A, Reina-Gutiérrez S, Lorenzo-García P, Martínez-Vizcaíno V
Institution:Health and Social Research Center, Universidad de Castilla- La Mancha, Cuenca, Spain.
Journal:Scand J Med Sci Sports. 2023 Jul;33(7):1040-1053. doi: 10.1111/sms.14360. Epub 2023 Apr 3.

8:Acupuncture May Help to Prevent Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Sham-Controlled, Single-Blind Study.
Authors:Huang MC, Chang SC, Liao WL, Ke TW, Lee AL, Wang HM, Chang CP, Yen HR, Chang HH, Chen WT
Institution:Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.; Division of Colorectal Surgery, Department of Surgery, China.
Journal:Oncologist. 2023 Jun 2;28(6):e436-e447. doi: 10.1093/oncolo/oyad065.

9:Assessment of autonomic nervous system dysfunction associated with peripheral neuropathies in the context of clinical neurophysiology practice.
Authors:Lefaucheur JP
Institution:Unite de Neurophysiologie Clinique, Hopital Henri Mondor, AP-HP, Creteil, France; UR ENT (EA4391), Faculte de Sante, Universite Paris Est Creteil, Creteil, France. Electronic address:
Journal:Neurophysiol Clin. 2023 Apr;53(2):102858. doi: 10.1016/j.neucli.2023.102858. Epub 2023 Mar 24.

10:The association of peripheral neuropathy detected by monofilament testing with risk of falls and fractures in older adults.
Authors:Hicks CW, Wang D, Daya N, Juraschek SP, Matsushita K, Windham BG, Selvin E
Institution:Division of Vascular Surgery and Endovascular Therapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Journal:J Am Geriatr Soc. 2023 Jun;71(6):1902-1909. doi: 10.1111/jgs.18338. Epub 2023 Mar 21.

11:Efficacy and safety of duloxetine in painful diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials.
Authors:Wu CS, Huang YJ, Ko YC, Lee CH
Institution:Department of Primary Care Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Plastic and Reconstructive Surgery, Division of Trauma Plastic Surgery, Chang Gung Memorial Hospital, No. 5, Fuxing St, Gueishan District 333, Linkou, Taiwan.
Journal:Syst Rev. 2023 Mar 21;12(1):53. doi: 10.1186/s13643-023-02185-6.

12:Statins and peripheral neuropathy in diabetic and non-diabetic cases: a systematic review.
Authors:Daliri M, Johnston TP, Sahebkar A
Institution:Orthopedics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal:J Pharm Pharmacol. 2023 Apr 17;75(5):593-611. doi: 10.1093/jpp/rgac104.

13:Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) with Non-Pharmacological Interventions: Clinical Recommendations from a Systematic Scoping Review and an Expert Consensus Process.
Authors:Klafke N, Bossert J, Kröger B, Neuberger P, Heyder U, Layer M, Winkler M, Idler C, Kaschdailewitsch E, Heine R, John H, Zielke T, Schmeling B, Joy S, Mertens I, Babadag-Savas B, Kohler S, Mahler C, Witt CM, Steinmann D, Voiss P, Stolz R
Institution:Department of General Practice and Health Services Research, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Institute for General Practice and Interprofessional Care, University Hospital Tubingen, 72076 Tubingen, Germany.
Journal:Med Sci (Basel). 2023 Jan 30;11(1):15. doi: 10.3390/medsci11010015.

14:Diabetic peripheral neuropathy essentials: a narrative review.
Authors:Chang MC, Yang S
Institution:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, South Korea.; Department of Rehabilitation Medicine, School of Medicine, Ewha Woman's University Seoul Hospital, Seoul, South Korea.
Journal:Ann Palliat Med. 2023 Mar;12(2):390-398. doi: 10.21037/apm-22-693. Epub 2023 Feb 8.

15:Acupuncture and integrative oncology for taxane-induced peripheral neuropathy: a randomized multicentered study.
Authors:Ben-Arye E, Gamus D, Samuels N, Schiff E, Hausner D, Gressel O, Attias S, Lavie O, David A, Shulman K, Agbarya A
Institution:The Oncology Service; Lin Medical Center, Clalit Health Services; Haifa and Western Galilee District, Haifa, Israel; Bnai Zion Medical Center, Haifa, Israel.
Journal:Int J Gynecol Cancer. 2023 May 1;33(5):792-801. doi: 10.1136/ijgc-2022-004004.

16:Prevention and therapy of chemotherapy-induced peripheral neuropathy: a review of recent findings.
Authors:Michalová Z, Székiová E, Blaško J, Vanický I
Institution:Institute of Neurobiology, Biomedical Research Center, Slovak Academy of Sciences, Kosice, Slovakia.
Journal:Neoplasma. 2023 Feb;70(1):15-35. doi: 10.4149/neo_2022_221007N992. Epub 2022 Dec 28.

17:Correlation between health literacy and health-related quality of life in patients with diabetic peripheral neuropathy: The mediating role of self-management.
Authors:Gao Y, Yan K, Yan X, Xi N, Gao J, Ren H
Institution:School of Nursing, Jinzhou Medical University, Jinzhou City, Liaoning Province, China.; First Affiliated Hospital of Jinzhou Medical University, Jinzhou City, Liaoning Province, China.
Journal:Nurs Open. 2023 May;10(5):3164-3177. doi: 10.1002/nop2.1566. Epub 2022 Dec 26.

18:Oral capsules of tetra-hydro-cannabinol (THC), cannabidiol (CBD) and their combination in peripheral neuropathic pain treatment.
Authors:Zubcevic K, Petersen M, Bach FW, Heinesen A, Enggaard TP, Almdal TP, Holbech JV, Vase L, Jensen TS, Hansen CS, Finnerup NB, Sindrup SH
Institution:Department of Neurology, Odense University Hospital, Odense, Denmark.
Journal:Eur J Pain. 2023 Apr;27(4):492-506. doi: 10.1002/ejp.2072. Epub 2023 Jan 12.

19:Physiotherapy interventions for pain relief in individuals with peripheral neuropathic pain: A systematic review and meta-analyses of randomized controlled trials.
Authors:Kannan P, Bello UM, Winser SJ
Institution:Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. Electronic address:; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong. Electronic address:
Journal:Contemp Clin Trials. 2023 Feb;125:107055. doi: 10.1016/j.cct.2022.107055. Epub 2022 Dec 16.

20:Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy.
Authors:Enders J, Elliott D, Wright DE
Institution:Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Journal:Antioxid Redox Signal. 2023 May;38(13-15):989-1000. doi: 10.1089/ars.2022.0158. Epub 2023 Feb 7.

21:Chemotherapy-Induced Peripheral Neuropathy.
Authors:Chen CS, Hertz DL
Institution:Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Journal:Handb Exp Pharmacol. 2023;277:299-337. doi: 10.1007/164_2022_609.

22:Duloxetine for prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN): systematic review and meta-analysis.
Authors:Chow R, Novosel M, So OW, Bellampalli S, Xiang J, Boldt G, Winquist E, Lock M, Lustberg M, Prsic E
Institution:Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Yale School of Medicine, Yale University, New Haven, Connecticut, USA
Journal:BMJ Support Palliat Care. 2023 Mar;13(1):27-34. doi: 10.1136/spcare-2022-003815. Epub 2022 Sep 8.

23:The effectiveness and safety of acupuncture/electroacupuncture for chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis.
Authors:Pei LX, Yi Y, Guo J, Chen L, Zhou JY, Wu XL, Sun JH, Chen H
Institution:Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.; Nanjing University of Chinese Medicine, Nanjing, China.
Journal:Acupunct Med. 2023 Apr;41(2):73-85. doi: 10.1177/09645284221076512. Epub 2022 Jun 12.

24:Effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis.
Authors:Guo S, Han W, Wang P, Wang X, Fang X
Institution:School of Nursing, Jilin University, 965 Xinjiang Street, Changchun, 130021, Jilin, China.; Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, China.
Journal:J Cancer Surviv. 2023 Apr;17(2):318-331. doi: 10.1007/s11764-022-01182-3. Epub 2022 Feb 11.

25:A systematic review of behavioural and exercise interventions for the prevention and management of chemotherapy-induced peripheral neuropathy symptoms.
Authors:Tanay MAL, Armes J, Moss-Morris R, Rafferty AM, Robert G
Institution:Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Journal:J Cancer Surviv. 2023 Feb;17(1):254-277. doi: 10.1007/s11764-021-00997-w. Epub 2021 Mar 12.

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