Peripheral Neuropathy
January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Peripheral Neuropathy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Peripheral Neuropathy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Peripheral Neuropathy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Peripheral Neuropathy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Targeting sensory neuron GPCRs for peripheral neuropathic pain.
Authors:Uniyal A, Tiwari V, Tsukamoto T, Dong X, Guan Y, Raja SN
Institution:Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, USA.; Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, USA; Department of Neurology and Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Journal:Trends Pharmacol Sci. 2023 Dec;44(12):1009-1027. doi: 10.1016/ Epub 2023 Nov 11.

2:Chemotherapy-Induced Peripheral Neuropathy: Diagnosis, Agents, General Clinical Presentation, and Treatments.
Authors:Molinares D, Kurtevski S, Zhu Y
Institution:Department of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, 1611 NW 12th avenue, Miami, FL, 33136, USA.
Journal:Curr Oncol Rep. 2023 Nov;25(11):1227-1235. doi: 10.1007/s11912-023-01449-7. Epub 2023 Sep 13.

3:How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview.
Authors:Li K, Chen Y, Xie J, Cai W, Pang C, Cui C, Huan Y, Deng B
Institution:Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China; First School of Clinical Medicine, Wenzhou Medical University, Wenzhou, PR China. Electronic address:
Journal:Ageing Res Rev. 2023 Nov;91:102064. doi: 10.1016/j.arr.2023.102064. Epub 2023 Sep 7.

4:Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy.
Authors:Jang HN, Oh TJ
Institution:Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Journal:Diabetes Metab J. 2023 Nov;47(6):743-756. doi: 10.4093/dmj.2023.0018. Epub 2023 Sep 6.

5:Real-Life Experiences of Chemotherapy-Induced Peripheral Neuropathy in Patients with Cancer: A Qualitative Meta-Synthesis Study.
Authors:Kim EY, Hong SJ
Institution:Assistant Professor, Department of Nursing, Soonchunhyang University, Cheonan, Republic of Korea.; Assistant Professor, College of Nursing, Gachon University, Incheon, Republic of Korea. Electronic address:
Journal:Semin Oncol Nurs. 2023 Oct;39(5):151499. doi: 10.1016/j.soncn.2023.151499. Epub 2023 Aug 14.

6:Nutritional peripheral neuropathies.
Authors:Kramarz C, Murphy E, Reilly MM, Rossor AM
Institution:Department of Neuromuscular Diseases, Queen Square UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.; Department of Neuromuscular Diseases, Queen Square UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
Journal:J Neurol Neurosurg Psychiatry. 2023 Dec 14;95(1):61-72. doi: 10.1136/jnnp-2022-329849.

7:Effectiveness of physiotherapy interventions on improving quality of life, total neuropathy score, strength and reducing pain in cancer survivors suffering from chemotherapy-induced peripheral neuropathy - a systematic review.
Authors:Seth NH, Qureshi I
Institution:Department of Neurophysiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research, Wardha, India.
Journal:Acta Oncol. 2023 Sep;62(9):1143-1151. doi: 10.1080/0284186X.2023.2238890. Epub 2023 Jul 31.

8:Peripheral Neuropathy in Diabetes: What Can MRI Do?
Authors:Zhang X, Zhang F
Institution:Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Shandong, China.
Journal:Diabetes. 2023 Aug 1;72(8):1060-1069. doi: 10.2337/db22-0912.

9:Clinical Recommendations for the use of Neurotropic B vitamins (B1, B6, and B12) for the Management of Peripheral Neuropathy: Consensus from a Multidisciplinary Expert Panel.
Authors:Pinzon RT, Schellack N, Matawaran BJ, Tsang MW, Deerochanawong C, Hiew FL, Nafach J, Khadilkar S
Institution:Department of Neurology, Duta Wacana Christian University/Bethesda Hospital, Yogyakarta, Indonesia; Corresponding Author.; Department of Neurology, Bombay Hospital Institute of Medical Sciences, Mumbai, India.
Journal:J Assoc Physicians India. 2023 Jul;71(7):11-12. doi: 10.59556/japi.71.0290.

10:The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review.
Authors:Muhamad R, Akrivaki A, Papagiannopoulou G, Zavridis P, Zis P
Institution:Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.; Second Department of Neurology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Journal:Nutrients. 2023 Jun 21;15(13):2823. doi: 10.3390/nu15132823.

11:Systematic review and meta-analysis of the effects of foot and ankle physical therapy, including mobilisations and exercises, in people with diabetic peripheral neuropathy on range of motion, peak plantar pressures and balance.
Authors:Lepesis V, Marsden J, Rickard A, Latour JM, Paton J
Institution:School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK.
Journal:Diabetes Metab Res Rev. 2023 Nov;39(8):e3692. doi: 10.1002/dmrr.3692. Epub 2023 Jul 10.

12:Investigation and Management of Immunoglobulin M- and Waldenström-Associated Peripheral Neuropathies.
Authors:Tomkins O, Leblond V, Lunn MP, Viala K, Weil DR, D'Sa S
Institution:Department of Haematology, Centre for Waldenstroms Macroglobulinaemia and Related Conditions, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK. Electronic address:; Department of Haematology, Centre for Waldenstroms Macroglobulinaemia and Related Conditions, University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK. Electronic address:
Journal:Hematol Oncol Clin North Am. 2023 Aug;37(4):761-776. doi: 10.1016/j.hoc.2023.04.007.

13:Nerve ultrasound for the diagnosis and follow-up of peripheral neuropathies.
Authors:Pitarokoili K, Gold R, Fisse AL
Institution:St. Josef Hospital, Ruhr-University, Bochum, Germany.
Journal:Curr Opin Neurol. 2023 Oct 1;36(5):373-381. doi: 10.1097/WCO.0000000000001183. Epub 2023 Jun 23.

14:L-Methylfolate in Diabetic Peripheral Neuropathy: A Narrative Review.
Authors:Christofides EA, Valentine V
Institution:Endocrinology Associates, Columbus, Ohio. Electronic address:; Clinica La Esperanza, Albuquerque, New Mexico.
Journal:Endocr Pract. 2023 Aug;29(8):663-669. doi: 10.1016/j.eprac.2023.04.005. Epub 2023 Apr 21.

15:Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral Neuropathy.
Authors:D'Souza RS, Alvarez GAM, Dombovy-Johnson M, Eller J, Abd-Elsayed A
Institution:Department of Anesthesiology and Perioperative Medicine, Mayo Clinic Hospital, Rochester, MN, USA.; Department of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Journal:Curr Pain Headache Rep. 2023 May;27(5):99-116. doi: 10.1007/s11916-023-01107-4. Epub 2023 Apr 14.

16:Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: A meta-analysis.
Authors:Nuñez de Arenas-Arroyo S, Cavero-Redondo I, Torres-Costoso A, Reina-Gutiérrez S, Lorenzo-García P, Martínez-Vizcaíno V
Institution:Health and Social Research Center, Universidad de Castilla- La Mancha, Cuenca, Spain.
Journal:Scand J Med Sci Sports. 2023 Jul;33(7):1040-1053. doi: 10.1111/sms.14360. Epub 2023 Apr 3.

17:Diabetic Peripheral Neuropathy is Associated With Diabetic Kidney Disease and Cardiovascular Disease: The Silesia Diabetes-Heart Project.
Authors:Nabrdalik K, Kwiendacz H, Moos J, Moos Ł, Kulpa J, Brzoza Z, Stompór T, Gumprecht J, Lip GYH
Institution:Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, UK.; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, UK; Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Journal:Curr Probl Cardiol. 2023 Aug;48(8):101726. doi: 10.1016/j.cpcardiol.2023.101726. Epub 2023 Mar 24.

18:Assessment of autonomic nervous system dysfunction associated with peripheral neuropathies in the context of clinical neurophysiology practice.
Authors:Lefaucheur JP
Institution:Unite de Neurophysiologie Clinique, Hopital Henri Mondor, AP-HP, Creteil, France; UR ENT (EA4391), Faculte de Sante, Universite Paris Est Creteil, Creteil, France. Electronic address:
Journal:Neurophysiol Clin. 2023 Apr;53(2):102858. doi: 10.1016/j.neucli.2023.102858. Epub 2023 Mar 24.

19:Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) with Non-Pharmacological Interventions: Clinical Recommendations from a Systematic Scoping Review and an Expert Consensus Process.
Authors:Klafke N, Bossert J, Kröger B, Neuberger P, Heyder U, Layer M, Winkler M, Idler C, Kaschdailewitsch E, Heine R, John H, Zielke T, Schmeling B, Joy S, Mertens I, Babadag-Savas B, Kohler S, Mahler C, Witt CM, Steinmann D, Voiss P, Stolz R
Institution:Department of General Practice and Health Services Research, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Institute for General Practice and Interprofessional Care, University Hospital Tubingen, 72076 Tubingen, Germany.
Journal:Med Sci (Basel). 2023 Jan 30;11(1):15. doi: 10.3390/medsci11010015.

20:Diabetic peripheral neuropathy essentials: a narrative review.
Authors:Chang MC, Yang S
Institution:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, South Korea.; Department of Rehabilitation Medicine, School of Medicine, Ewha Woman's University Seoul Hospital, Seoul, South Korea.
Journal:Ann Palliat Med. 2023 Mar;12(2):390-398. doi: 10.21037/apm-22-693. Epub 2023 Feb 8.

21:The Therapeutic Potential of Antioxidants in Chemotherapy-Induced Peripheral Neuropathy: Evidence from Preclinical and Clinical Studies.
Authors:Zhou L, Yang H, Wang J, Liu Y, Xu Y, Xu H, Feng Y, Ge W
Institution:Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, #321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
Journal:Neurotherapeutics. 2023 Mar;20(2):339-358. doi: 10.1007/s13311-023-01346-8. Epub 2023 Feb 3.

22:Prevention and therapy of chemotherapy-induced peripheral neuropathy: a review of recent findings.
Authors:Michalová Z, Székiová E, Blaško J, Vanický I
Institution:Institute of Neurobiology, Biomedical Research Center, Slovak Academy of Sciences, Kosice, Slovakia.
Journal:Neoplasma. 2023 Feb;70(1):15-35. doi: 10.4149/neo_2022_221007N992. Epub 2022 Dec 28.

23:Physiotherapy interventions for pain relief in individuals with peripheral neuropathic pain: A systematic review and meta-analyses of randomized controlled trials.
Authors:Kannan P, Bello UM, Winser SJ
Institution:Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. Electronic address:; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong. Electronic address:
Journal:Contemp Clin Trials. 2023 Feb;125:107055. doi: 10.1016/j.cct.2022.107055. Epub 2022 Dec 16.

24:Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy.
Authors:Enders J, Elliott D, Wright DE
Institution:Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Journal:Antioxid Redox Signal. 2023 May;38(13-15):989-1000. doi: 10.1089/ars.2022.0158. Epub 2023 Feb 7.

25:A systematic review of behavioural and exercise interventions for the prevention and management of chemotherapy-induced peripheral neuropathy symptoms.
Authors:Tanay MAL, Armes J, Moss-Morris R, Rafferty AM, Robert G
Institution:Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Journal:J Cancer Surviv. 2023 Feb;17(1):254-277. doi: 10.1007/s11764-021-00997-w. Epub 2021 Mar 12.

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