Trigeminal Neuralgia
January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:The long-term outcome of CT-guided radiofrequency ablation of the peripheral branches of the trigeminal nerve in trigeminal neuralgia.
Authors:Huang P, Liu H, Huang L, Jin X
Institution:Department of Anesthesiology and Pain Management, The First Affiliated Hospital of Soochow University, Pinghai Road No. 899, Suzhou City, Jiangsu, China.
Journal:Neurosurg Rev. 2024 Jan 6;47(1):33. doi: 10.1007/s10143-023-02269-w.

2:Effectiveness of gamma knife radiosurgery in the management of trigeminal neuralgia associated with multiple sclerosis: a systematic review and meta-analysis.
Authors:Ali SMS, Shafique MA, Mustafa MS, Jafri SAA, Khalil S, Fatima H, Rangwala HS
Institution:Department of Medicine, Liaquat National Hospital & Medical College, Stadium Road, Karachi, 74800, Pakistan.; Department of Medicine, Jinnah Sindh Medical University, Iqbal Shaheed Rd, Karachi, 75510, Pakistan.
Journal:Neurosurg Rev. 2023 Dec 13;47(1):12. doi: 10.1007/s10143-023-02246-3.

3:The Therapeutic Effect of Botulinum Toxin Type A on Trigeminal Neuralgia: Are There Any Differences between Type 1 versus Type 2 Trigeminal Neuralgia?
Authors:Tereshko Y, Valente M, Belgrado E, Dalla Torre C, Dal Bello S, Merlino G, Gigli GL, Lettieri C
Institution:Clinical Neurology Unit, Udine University Hospital, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.
Journal:Toxins (Basel). 2023 Nov 14;15(11):654. doi: 10.3390/toxins15110654.

4:Microvascular decompression for trigeminal neuralgia: A retrospective analysis of long-term outcomes and prognostic factors.
Authors:Amaya Pascasio L, De La Casa-Fages B, Esteban de Antonio E, Grandas F, García-Leal R, Ruiz Juretschke F
Institution:Neurology Department, Hospital General Universitario Gregorio Maranon, Madrid, Spain. Electronic address:; Neurosurgery Department, Hospital General Universitario Gregorio Maranon, Madrid, Spain.
Journal:Neurologia (Engl Ed). 2023 Nov-Dec;38(9):625-634. doi: 10.1016/j.nrleng.2021.03.010.

5:Efficacy and Complications of Percutaneous Balloon Compression for Patients With Trigeminal Neuralgia With and Without Concomitant Continuous Pain.
Authors:Li S, Liao C, Wang G, Zhang Y, Wu Y, Zhang W
Institution:Department of Neurosurgery, Shanghai Ninth People's Hospital, affiliated with Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Journal:Pain Physician. 2023 Nov;26(7):E823-E832.

6:Effectiveness of percutaneous balloon compression (PBC) in improving physical function and quality of life in trigeminal neuralgia: a retrospective study.
Authors:Huang P, Liu H, Liu Z, Huang L, Lu M, Wang L, Yu Y, Jin X
Institution:Department of Anesthesiology and Pain, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Journal:Acta Neurochir (Wien). 2023 Dec;165(12):3905-3912. doi: 10.1007/s00701-023-05823-z. Epub 2023 Oct 28.

7:Endoscopic microvascular decompression versus microscopic microvascular decompression for trigeminal neuralgia: A systematic review and meta-analysis.
Authors:Chen L, Shang Y, Zhang Y, Zhao Y
Institution:Department of Neurosurgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China. Electronic address:
Journal:J Clin Neurosci. 2023 Nov;117:73-78. doi: 10.1016/j.jocn.2023.09.009. Epub 2023 Sep 28.

8:Single OnabotulinumtoxinA Session Add-On to Carbamazepine or Oxcarbazepine in Treatment-Refractory Trigeminal Neuralgia: A Case Series with 24-Week Follow Up.
Authors:Xiromerisiou G, Lampropoulos IC, Dermitzakis EV, Vikelis M, Marogianni C, Mysiris D, Argyriou AA
Institution:Department of Neurology, Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, 41110 Larissa, Greece.; Headache Outpatient Clinic, Department of Neurology, Agios Andreas State General Hospital of Patras, 26335 Patras, Greece.
Journal:Toxins (Basel). 2023 Aug 31;15(9):539. doi: 10.3390/toxins15090539.

9:Percutaneous glycerol rhizolysis of the trigeminal ganglion for the treatment of idiopathic and classic trigeminal neuralgia: Outcomes and complications.
Authors:Bethamcharla R, Abou-Al-Shaar H, Maarbjerg S, Chang YF, Gacka CN, Sekula RF Jr
Institution:Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA.
Journal:Eur J Neurol. 2023 Oct;30(10):3307-3313. doi: 10.1111/ene.15977. Epub 2023 Jul 18.

10:Treatment of pediatric trigeminal neuralgia with microvascular decompression: a case series and systematic review.
Authors:Grossen AA, Iser CR, Leming AB, Desai VR, Chrusciel DG
Institution:Departments of1Neurosurgery and.; 3Neurology, University of Oklahoma Health Sciences Center.
Journal:J Neurosurg Pediatr. 2023 Jun 16;32(3):384-393. doi: 10.3171/2023.4.PEDS22494. Print 2023 Sep 1.

11:Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis.
Authors:Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Institution:KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea. Electronic address:
Journal:Complement Ther Clin Pract. 2023 Aug;52:101763. doi: 10.1016/j.ctcp.2023.101763. Epub 2023 May 2.

12:Trigeminal neuralgia in multiple sclerosis: Association with demyelination and progression.
Authors:Mousavi SH, Lindsey JW, Gupta RK, Wolinsky JS, Lincoln JA
Institution:Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston (UTHealth), 6431 Fannin Street MSB 7.221 Houston, TX 77030, USA. Electronic address:
Journal:Mult Scler Relat Disord. 2023 Jun;74:104727. doi: 10.1016/j.msard.2023.104727. Epub 2023 Apr 17.

13:Peripheral nerve pulsed radiofrequency for trigeminal neuralgia treatment: Is it an effective method?
Authors:Tanyel T, Bilir A, Güleç MS
Institution:Department of Algology, Malatya Training and Research Hospital, Malatya, Turkiye.; Department of Algology, Eski?ehir Osmangazi University Faculty of Medicine, Eski?ehir, Turkiye.
Journal:Agri. 2023 Apr;35(2):96-102. doi: 10.14744/agri.2022.93609.

14:Current Applications of Ablative Therapies for Trigeminal Neuralgia.
Authors:Chakraborty AR, Sunshine K, Miller JP, Sweet JA
Institution:Department of Neurological Surgery, University Hospitals, Cleveland Medical Center, 11100 Euclid Avenue, HAN 5042, Cleveland, OH 44106, USA; Case Western Reserve University, School of Medicine, Cleveland, OH, USA. Electronic address:
Journal:Neurosurg Clin N Am. 2023 Apr;34(2):285-290. doi: 10.1016/

15:Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia Secondary to Multiple Sclerosis: A Case-Control Study.
Authors:Leduc W, Mathieu D, Adam E, Ferreira R, Iorio-Morin C
Institution:Department of Neurology, Universite de Sherbrooke, Qc, Canada.; Department of Neurosurgery, Universite de Sherbrooke, Qc, Canada.
Journal:Neurosurgery. 2023 Aug 1;93(2):453-461. doi: 10.1227/neu.0000000000002440. Epub 2023 Mar 2.

16:Is percutaneous balloon compression better than microvascular decompression to treat trigeminal neuralgia? A systematic review and meta-analysis.
Authors:Nascimento RFV, Pipek LZ, de Aguiar PHP
Institution:Centro universitario FMABC, Santo Andre, Sao Paulo, Brazil.; Department of Neurosurgery, Santa Paula Hospital, Sao Paulo, Brazil; Department of Research and Innovation, Laboratory of Cellular and Molecular Biology, FMABC, Santo Andre, Sao Paulo, Brazil; Department of Neurology, School of Medicine of Pontifical Catholic University of Sao Paulo, Sorocaba, Sao Paulo, Brazil; State Serviant Public Hospital, Sao Paulo, Brazil.
Journal:J Clin Neurosci. 2023 Mar;109:11-20. doi: 10.1016/j.jocn.2023.01.002. Epub 2023 Jan 10.

17:Trigeminal Neuralgia: Diagnosis and Treatment.
Authors:Allam AK, Sharma H, Larkin MB, Viswanathan A
Institution:Department of Neurosurgery, Baylor College of Medicine, 7200 Cambridge St, Suite 9A, Houston, TX 77030, USA. Electronic address:
Journal:Neurol Clin. 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001.

18:Percutaneous Radiofrequency Ablation for Trigeminal Neuralgia Management: A Randomized, Double-Blinded, Sham-Controlled Clinical Trial.
Authors:Mansano AM, Frederico TN, Valentin REB, Carmona MJC, Ashmawi HA
Institution:Anesthesiology Department, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Journal:Pain Med. 2023 Mar 1;24(3):234-243. doi: 10.1093/pm/pnac132.

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