Trigeminal Neuralgia
July 2023 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Guidelines for the management of trigeminal neuralgia.
Authors:Chong MS, Bahra A, Zakrzewska JM
Institution:Consultant Neurologist, National Hospital for Neurology and Neurosurgery, London, UK; Member, Medical Advisory Committee for Trigeminal Neuralgia Association UK; Professor of Pain in Relation to Oral Medicine, National Hospital for Neurology and Neurosurgery, London, UK; Royal National ENT & Eastman Dental Hospitals, UCLH NHS Foundation Trust, London, UK; Cleveland Clinic London, UK; Co-Founder, Trigeminal Neuralgia Institute; Member of European and UK guidelines committee for trigeminal neuralgia; Principal Investigator for phase 2 drug trials for trigeminal neuralgia.
Journal:Cleve Clin J Med. 2023 Jun 1;90(6):355-362. doi: 10.3949/ccjm.90a.22052.

2:Radiosurgery for classical trigeminal neuralgia: impact of the shot size on clinical outcome.
Authors:Ortholan C, Colin P, Serrano B, Bouet T, Garnier N, le Guyader M, Amblard R, Villeneuve R, Chanalet S, Alchaar H, Bozzolo E, Lanteri-Minet M, Fontaine D
Institution:Department of Radiotherapy, Centre Hospitalier Princesse Grace, Monaco, Monaco.; FHU Inovpain, Centre Hospitalier Universitaire de Nice, Universite Cote d'Azur, Nice, France.
Journal:J Headache Pain. 2023 May 11;24(1):51. doi: 10.1186/s10194-023-01583-4.

3:Efficacy and safety of computed tomography-guided percutaneous balloon compression for trigeminal neuralgia secondary to vertebrobasilar dolichoectasia.
Authors:Zhang W, Zhao C, Shen Y, Xing Y, Luo F
Institution:Department of Day Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People's Republic of China.; Department of Day Surgery and Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People's Republic of China.
Journal:Neurosurg Rev. 2023 May 8;46(1):112. doi: 10.1007/s10143-023-02019-y.

4:Sequential onset of bilateral trigeminal neuralgia: clinical presentation and outcomes.
Authors:Xu R, So RJ, Lee KK, Kalluri AL, Materi J, Nair SK, Huang J, Lim M, Bettegowda C
Institution:Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:
Journal:Clin Neurol Neurosurg. 2023 Jun;229:107745. doi: 10.1016/j.clineuro.2023.107745. Epub 2023 Apr 29.

5:A case of severe trigeminal neuralgia: recovery by means of stellate ganglion block with procaine. Discussion of possible mechanisms of action.
Authors:Lopes CA, Fischer L
Institution:Department of Complementary and Integrative Medicine, University of Bern, Bern, Switzerland.
Journal:J Int Med Res. 2023 Apr;51(4):3000605231164479. doi: 10.1177/03000605231164479.

6:Efficacy of surgical treatment in patients with trigeminal neuralgia secondary to multiple sclerosis: A prospective study of 18 cases with evaluation of outcome and complications by independent evaluators.
Authors:Worm J, Noory N, Smilkov EA, Heinskou TB, Andersen ASS, Springborg JB, Rochat P, Frederiksen JL, Bendtsen L, Maarbjerg S
Institution:Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Denmark.
Journal:Cephalalgia. 2023 May;43(5):3331024231167130. doi: 10.1177/03331024231167130.

7:Oral lacosamide for the treatment of refractory trigeminal neuralgia: A retrospective analysis of 86 cases.
Authors:Muñoz-Vendrell A, Tena-Cucala R, Campoy S, García-Parra B, Prat J, Martínez-Yélamos S, Huerta-Villanueva M
Institution:Neurology Service, Headache Unit, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Journal:Headache. 2023 Apr;63(4):559-564. doi: 10.1111/head.14505. Epub 2023 Apr 10.

8:Lidocaine aerosol sprayed on oral and/or nasal mucosa for the rescue of acute trigeminal neuralgia exacerbations: A retrospective study.
Authors:Zhou X, Shen Y, Zhao C, Luo F
Institution:Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Journal:Cephalalgia. 2023 May;43(5):3331024231168086. doi: 10.1177/03331024231168086.

9:Safety and Efficacy of Gamma Knife Radiosurgery for the Management of Trigeminal Neuralgia: A Retrospective and Cross-Sectional Study.
Authors:Okunlola AI, Pattankar S, Warade A, Khandhar A, Mistry V, Misra BK
Institution:Department of Surgery, Federal Teaching Hospital, Ido-Ekiti/Afe Babalola University, Ado-Ekiti, Nigeria.; Department of Neurosurgery and Gamma Knife Surgery, P D Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
Journal:Neurol India. 2023 Mar-Apr;71(Supplement):S161-S167. doi: 10.4103/0028-3886.373623.

10:Effects of Microvascular Decompression on Pain Relief and Quality of Life in Late Elderly Patients with Trigeminal Neuralgia.
Authors:Otsu Y, Kajiwara S, Hashimoto A, Sakata K, Negoto T, Hasegawa Y, Nakamura H, Hirohata M, Morioka M
Institution:Department of Neurosurgery, Kurume University School of Medicine.
Journal:Neurol Med Chir (Tokyo). 2023 Jun 15;63(6):236-242. doi: 10.2176/jns-nmc.2022-0288. Epub 2023 Apr 6.

11:Open surgery vs. stereotactic radiosurgery for tumour-related trigeminal neuralgia: A systematic review.
Authors:Nugroho SW, Anindya Y, Hafif M, Wicaksana BA, Desbassari F, Sadewo W, Perkasa SAH
Institution:Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Electronic address:
Journal:Clin Neurol Neurosurg. 2023 May;228:107683. doi: 10.1016/j.clineuro.2023.107683. Epub 2023 Mar 21.

12:Microvascular decompression for young onset primary trigeminal neuralgia: a single-center experience.
Authors:Zhu C, Jiang C, Xu W, Wang J, Chong Y, Liang W
Institution:Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210009, Jiangsu, China.
Journal:Neurosurg Rev. 2023 Mar 14;46(1):69. doi: 10.1007/s10143-023-01978-6.

13:Current Applications of Ablative Therapies for Trigeminal Neuralgia.
Authors:Chakraborty AR, Sunshine K, Miller JP, Sweet JA
Institution:Department of Neurological Surgery, University Hospitals, Cleveland Medical Center, 11100 Euclid Avenue, HAN 5042, Cleveland, OH 44106, USA; Case Western Reserve University, School of Medicine, Cleveland, OH, USA. Electronic address:
Journal:Neurosurg Clin N Am. 2023 Apr;34(2):285-290. doi: 10.1016/

14:Outcomes After Microvascular Decompression for Sole Arterial Versus Venous Compression in Trigeminal Neuralgia.
Authors:Nair SK, Xie ME, Ran K, Kalluri A, Kilgore C, Huang J, Lim M, Bettegowda C, Xu R
Institution:Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:
Journal:World Neurosurg. 2023 May;173:e542-e547. doi: 10.1016/j.wneu.2023.02.090. Epub 2023 Mar 6.

15:Multiple Vessel Compression of the Trigeminal Nerve Is Associated With Worse Outcomes in Trigeminal Neuralgia After Microvascular Decompression.
Authors:So RJ, Kalluri AL, Zhu S, Materi J, Nair SK, Lim M, Huang J, Bettegowda C, Xu R
Institution:Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal:Neurosurgery. 2023 May 1;92(5):1029-1034. doi: 10.1227/neu.0000000000002323. Epub 2022 Dec 30.

16:Is percutaneous balloon compression better than microvascular decompression to treat trigeminal neuralgia? A systematic review and meta-analysis.
Authors:Nascimento RFV, Pipek LZ, de Aguiar PHP
Institution:Centro universitario FMABC, Santo Andre, Sao Paulo, Brazil.; Department of Neurosurgery, Santa Paula Hospital, Sao Paulo, Brazil; Department of Research and Innovation, Laboratory of Cellular and Molecular Biology, FMABC, Santo Andre, Sao Paulo, Brazil; Department of Neurology, School of Medicine of Pontifical Catholic University of Sao Paulo, Sorocaba, Sao Paulo, Brazil; State Serviant Public Hospital, Sao Paulo, Brazil.
Journal:J Clin Neurosci. 2023 Mar;109:11-20. doi: 10.1016/j.jocn.2023.01.002. Epub 2023 Jan 10.

17:Long-Term Results of Gamma Knife Radiosurgery for Trigeminal Neuralgia.
Authors:Sato D, Hayashi M, Horiba A, Horisawa S, Kawamata T
Institution:Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
Journal:World Neurosurg. 2023 Mar;171:e787-e791. doi: 10.1016/j.wneu.2022.12.110. Epub 2022 Dec 28.

18:Ultrasound-guided dry needling of masticatory muscles in trigeminal neuralgia - A case series of 35 patients.
Authors:Vas L, Phanse S, Pawar KS, Pai R, Pattnaik M
Institution:Ashirvad Institute for Pain Management and Research, Mumbai, Maharashtra, India.
Journal:J Postgrad Med. 2023 Jan-Mar;69(1):11-20. doi: 10.4103/jpgm.jpgm_797_21.

19:Trigeminal Neuralgia: Diagnosis and Treatment.
Authors:Allam AK, Sharma H, Larkin MB, Viswanathan A
Institution:Department of Neurosurgery, Baylor College of Medicine, 7200 Cambridge St, Suite 9A, Houston, TX 77030, USA. Electronic address:
Journal:Neurol Clin. 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001.

20:Percutaneous Radiofrequency Ablation for Trigeminal Neuralgia Management: A Randomized, Double-Blinded, Sham-Controlled Clinical Trial.
Authors:Mansano AM, Frederico TN, Valentin REB, Carmona MJC, Ashmawi HA
Institution:Anesthesiology Department, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Journal:Pain Med. 2023 Mar 1;24(3):234-243. doi: 10.1093/pm/pnac132.

21:Internal neurolysis versus intraoperative glycerin rhizotomy for trigeminal neuralgia.
Authors:Xu R, Materi J, Raj D, Alomari S, Xia Y, Nair SK, Shah PP, Kannapadi N, Kim T, Huang J, Bettegowda C, Lim M
Institution:1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.; 2Department of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Journal:J Neurosurg. 2022 May 6;138(1):270-275. doi: 10.3171/2022.3.JNS212956. Print 2023 Jan 1.

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