Reflex Sympathetic Dystrophy
January 2024 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Reflex Sympathetic Dystrophy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Reflex Sympathetic Dystrophy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Reflex Sympathetic Dystrophy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Reflex Sympathetic Dystrophy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Safety and Efficacy of Intravenous ExoFlo in the Treatment of Complex Regional Pain Syndrome.
Authors:Paicius R, White ZS, Smith C, Lightner AL, Ransom JT, Lee DW, Speare S
Institution:SC Spine & Sport, Newport Beach, CA; Newport Coast Surgery Center, Newport Beach, CA.; SC Spine & Sport, Newport Beach, CA.
Journal:Pain Physician. 2023 Nov;26(7):E851-E857.

2:Safety and Effectiveness of Stellate Ganglion Cryoablation in Complex Regional Pain Syndrome.
Authors:Latour C, Prologo JD, Lin M, Amsbaugh A, Xhang Z, Levey AO
Institution:Department of Interventional Radiology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas; Department of Interventional Radiology, Washington University School of Medicine, St. Louis, Missouri. Electronic address:; Department of Interventional Radiology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas.
Journal:J Vasc Interv Radiol. 2024 Jan;35(1):69-73. doi: 10.1016/j.jvir.2023.09.030. Epub 2023 Oct 4.

3:Experiences of diagnosis and treatment for upper limb Complex Regional Pain Syndrome: a qualitative analysis.
Authors:Griffiths GS, Thompson BL, Snell DL, Dunn JA
Institution:Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch 8011, New Zealand.
Journal:Pain Med. 2023 Dec 1;24(12):1355-1363. doi: 10.1093/pm/pnad111.

4:Complex regional pain syndrome.
Authors:Mills M, Howell CM
Institution:At the time this article was written, Micayah Mills was a student in the PA program at Kettering (Ohio) College. She now practices at Kettering Health Brain and Spine Center. Christopher M. Howell is an associate professor and program director of the PA program at Miami University in Oxford, Ohio. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Journal:JAAPA. 2023 Aug 1;36(8):1-5. doi: 10.1097/01.JAA.0000931440.10463.f2.

5:Scrambler Therapy for Patients With Complex Regional Pain Syndrome: A Case Series.
Authors:Wang AT, Wang EJ, Smith TJ, Razzak R, Christo PJ
Institution:Department of Anesthesiology and Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal:J Palliat Med. 2023 Sep;26(9):1302-1306. doi: 10.1089/jpm.2022.0539. Epub 2023 Jul 21.

6:Complex Regional Pain Syndrome: Evidence-Based Advances in Concepts and Treatments.
Authors:Limerick G, Christo DK, Tram J, Moheimani R, Manor J, Chakravarthy K, Karri J, Christo PJ
Institution:Division of Pain Medicine, Department of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Journal:Curr Pain Headache Rep. 2023 Sep;27(9):269-298. doi: 10.1007/s11916-023-01130-5. Epub 2023 Jul 8.

7:Complex Regional Pain Syndrome (CRPS) and the Value of Early Detection.
Authors:Harnik MA, Kesselring P, Ott A, Urman RD, Luedi MM
Institution:Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Journal:Curr Pain Headache Rep. 2023 Sep;27(9):417-427. doi: 10.1007/s11916-023-01124-3. Epub 2023 Jul 6.

8:Pediatric Complex Regional Pain Syndrome With and Without a History of Prior Physical Trauma at Onset.
Authors:Sherry DD, Mondal A, McGill M, Gmuca S
Institution:Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia.
Journal:Clin J Pain. 2023 Sep 1;39(9):437-441. doi: 10.1097/AJP.0000000000001140.

9:Effectiveness of the physiotherapy interventions on complex regional pain syndrome in patients with stroke: A systematic review and meta-analysis.
Authors:Kanika, Goyal M, Goyal K
Institution:Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to Be University), Mullana- Ambala, Haryana, 133207, India. Electronic address:; Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to Be University), Mullana- Ambala, Haryana, 133207, India. Electronic address:
Journal:J Bodyw Mov Ther. 2023 Jul;35:175-181. doi: 10.1016/j.jbmt.2023.04.040. Epub 2023 Apr 29.

10:Anxiety, Disability, and Pain Predict Outcomes of Complex Regional Pain Syndrome: An 8-year Follow-up of a Prospective Cohort.
Authors:Cave SA, Reynolds LM, Tuck NL, Aamir T, Lee AC, Bean DJ
Institution:Department of Psychological Medicine, The University of Auckland,Auckland, New Zealand; Department of Anaesthesiology & Perioperative Medicine, Te Whatu Ora Health New Zealand - Waitemat?, Auckland, New Zealand.; Department of Anaesthesiology & Perioperative Medicine, Te Whatu Ora Health New Zealand - Waitemat?, Auckland, New Zealand; Health & Rehabilitation Research Institute, Auckland University of Technology, Auckland, New Zealand. Electronic address:
Journal:J Pain. 2023 Nov;24(11):1957-1967. doi: 10.1016/j.jpain.2023.06.003. Epub 2023 Jun 14.

11:Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.
Authors:Ferraro MC, Cashin AG, Wand BM, Smart KM, Berryman C, Marston L, Moseley GL, McAuley JH, O'Connell NE
Institution:Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.; Department of Health Sciences, Centre for Health and Wellbeing Across the Lifecourse, Brunel University London, Uxbridge, UK.
Journal:Cochrane Database Syst Rev. 2023 Jun 12;6(6):CD009416. doi: 10.1002/14651858.CD009416.pub3.

12:Prednisolone 20 mg vs 40 mg in complex regional pain syndrome type I: A randomized controlled trial.
Authors:Kalita J, Pandey PC, Shukla R, Misra UK
Institution:Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226014, India. Electronic address:
Journal:J Clin Neurosci. 2023 Jul;113:108-113. doi: 10.1016/j.jocn.2023.05.017. Epub 2023 May 29.

13:Ketamine for Complex Regional Pain Syndrome: A Narrative Review Highlighting Dosing Practices and Treatment Response.
Authors:Lii TR, Singh V
Institution:Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, 450 Broadway Street, MC6343, Redwood City, CA 94063, USA.; Department of Anesthesiology, Emory University, 550 Peachtree Street, Emory University Hospital Midtown, Atlanta, GA 30308, USA. Electronic address:
Journal:Anesthesiol Clin. 2023 Jun;41(2):357-369. doi: 10.1016/j.anclin.2023.03.005. Epub 2023 Apr 14.

14:Perspectives on the pharmacological management of complex regional pain syndrome.
Authors:Norton KF, Furnish TJ
Institution:Department of Anesthesiology, UC San Diego Medical Center, San Diego, CA, USA.
Journal:Expert Opin Pharmacother. 2023 May-Aug;24(11):1295-1305. doi: 10.1080/14656566.2023.2218032. Epub 2023 May 27.

15:Rehabilitation Interventions for Complex Regional Pain Syndrome: An Overview of Systematic Reviews.
Authors:Shafiee E, MacDermid J, Packham T, Grewal R, Farzad M, Bobos P, Walton D
Institution:School of Physical Therapy, Department of Health and Rehabilitation Sciences, University of Western Ontario, ON, Canada.
Journal:Clin J Pain. 2023 Sep 1;39(9):473-483. doi: 10.1097/AJP.0000000000001133.

16:Incidence and risk factors for complex regional pain syndrome in radius fractures: meta-analysis.
Authors:Lorente A, Mariscal G, Lorente R
Institution:Department of Traumatology and Orthopaedic Surgery, University Hospital Ramon y Cajal, Madrid, Spain.; Department of Orthopedic Surgery and Traumatology, University Hospital of Badajoz, Badajoz, Spain.
Journal:Arch Orthop Trauma Surg. 2023 Sep;143(9):5687-5699. doi: 10.1007/s00402-023-04909-8. Epub 2023 May 20.

17:Management of complex regional pain syndrome in trauma and orthopaedic surgery-a systematic review.
Authors:Saed A, Neal-Smith G, Fernquest S, Bourget-Murray J, Wood A
Institution:Investigation Performed at the Trauma & Orthopaedic Department, Oxford Trauma Unit, John Radcliffe Hospital, Oxford, UK.
Journal:Br Med Bull. 2023 Jun 21;146(1):27-42. doi: 10.1093/bmb/ldac034.

18:Resilience in patients with complex regional pain syndrome 1-a cross-sectional analysis of patients participating in a cross-sectional cohort study.
Authors:Wertli MM, Aegler B, McCabe CS, Grieve S, Llewellyn A, Schneider S, Bachmann LM, Brunner F
Institution:Department of General Internal Medicine, Cantonal Hospital Baden, Baden 5404, Switzerland.; Department of Physical Medicine and Rheumatology, Balgrist University Hospital, Zurich 8004, Switzerland.
Journal:Pain Med. 2023 Sep 1;24(9):1066-1072. doi: 10.1093/pm/pnad055.

19:Clinical results of lumbar sympathetic blocks in lower limb complex regional pain syndrome using infrared thermography as a support tool.
Authors:Bovaira M, Cañada-Soriano M, García-Vitoria C, Calvo A, De Andrés JA, Moratal D, Priego-Quesada JI
Institution:Anaesthesia Department, Hospital Intermutual de Levante, Sant Antoni de Benaixeve, Spain.; Research Group in Sports Biomechanics (GIBD), Department of Physical Education and Sports, University of Valencia, Valencia, Spain.
Journal:Pain Pract. 2023 Sep;23(7):713-723. doi: 10.1111/papr.13236. Epub 2023 Apr 22.

20:Diagnosis and Outcomes of 225 Consecutive Cases of Complex Regional Pain Syndrome of the Hand.
Authors:Del Piñal F
Institution:From private practice.
Journal:Plast Reconstr Surg. 2023 Oct 1;152(4):807-816. doi: 10.1097/PRS.0000000000010454. Epub 2023 Mar 24.

21:Complex regional pain syndrome: diagnosis and management.
Authors:Rose E
Institution:Institute of Health, University of Cumbria, Lancaster, England.
Journal:Nurs Stand. 2023 Apr 5;38(4):57-61. doi: 10.7748/ns.2023.e11968. Epub 2023 Mar 20.

22:The Effectiveness of Rehabilitation Interventions on Pain and Disability for Complex Regional Pain Syndrome: A Systematic Review and Meta-analysis.
Authors:Shafiee E, MacDermid J, Packham T, Walton D, Grewal R, Farzad M
Institution:Department of Health and Rehabilitation Sciences School of Physical Therapy.; Department of Health and Rehabilitation Sciences School of Physical Therapy, University of Western Ontario.
Journal:Clin J Pain. 2023 Feb 1;39(2):91-105. doi: 10.1097/AJP.0000000000001089.

23:Randomized controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in adults with complex regional pain syndrome.
Authors:Ratcliffe S, Arkilo D, Asgharnejad M, Bhattacharya S, Harden RN
Institution:St Pancras Clinical Research, London, EC2Y 8EA, United Kingdom.; Departments of Physical Medicine and Rehabilitation and Physical Therapy and Human Movement Science, , Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.
Journal:Pain Med. 2023 Jul 5;24(7):872-880. doi: 10.1093/pm/pnac198.

24:Biological and psychological early prognostic factors in complex regional pain syndrome: A systematic review.
Authors:Louis MH, Meyer C, Legrain V, Berquin A
Institution:Institute of Neuroscience, Universite catholique de Louvain, Brussels, Belgium.
Journal:Eur J Pain. 2023 Mar;27(3):338-352. doi: 10.1002/ejp.2068. Epub 2022 Dec 25.

25:Efficacy and Safety of Cervical and High-Thoracic Dorsal Root Ganglion Stimulation Therapy for Complex Regional Pain Syndrome of the Upper Extremities.
Authors:Graca MJ, Lubenow TR, Landphair WR, McCarthy RJ
Institution:Department of Anesthesiology, Rush University Medical Center, Chicago, IL, USA.
Journal:Neuromodulation. 2023 Dec;26(8):1781-1787. doi: 10.1016/j.neurom.2022.09.007. Epub 2022 Nov 16.

26:Cervical dorsal root ganglion stimulation for complex regional pain syndrome: Technical description and results of seven cases.
Authors:Rosado Caracena R, Mendiola de la Osa A, Rincón Higuera A, Abad Fau de Casajuana E, Ruiz Córdoba G, García de Lucas F
Institution:Hospital FREMAP Majadahonda, Majadahonda, Madrid, Spain.
Journal:Pain Pract. 2023 Mar;23(3):242-251. doi: 10.1111/papr.13183. Epub 2022 Nov 25.

27:Amputation for Complex Regional Pain Syndrome: Meta-Analysis and Validation of a Histopathology Scoring System.
Authors:Howard EL, Singleton M, Soulakvelidze I
Institution:Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, Washington, USA.
Journal:Pain Med. 2023 Apr 3;24(4):425-441. doi: 10.1093/pm/pnac168.

28:Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study.
Authors:Cohen SP, Khunsriraksakul C, Yoo Y, Parker E, Samen-Akinsiku CDK, Patel N, Cohen SJ, Yuan X, Cheng J, Moon JY
Institution:Departments of Anesthesiology & Critical Care Medicine, Neurology, Physical Medicine & Rehabilitation, and Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.; Department of Anesthesiology, Seoul National University, Seoul, Korea.
Journal:Pain Med. 2023 Mar 1;24(3):316-324. doi: 10.1093/pm/pnac153.

29:Complex regional pain syndrome following vascular access creation for hemodialysis.
Authors:Sathiavageesan S, Annamalai I, Karki A, Kamalanathan M, Annadurai A, Chandrasekaran A
Institution:Department of Nephrology, Trichy SRM Medical College Hospital & Research Centre, Trichy, Tamil Nadu, India.; Department of Surgery, Sundaram Hospital, Puthur, Trichy, Tamil Nadu, India.
Journal:J Vasc Access. 2023 Nov;24(6):1535-1537. doi: 10.1177/11297298221091766. Epub 2022 Apr 23.

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