Reflex Sympathetic Dystrophy
July 2023 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Reflex Sympathetic Dystrophy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Reflex Sympathetic Dystrophy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Reflex Sympathetic Dystrophy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Reflex Sympathetic Dystrophy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.
Authors:Ferraro MC, Cashin AG, Wand BM, Smart KM, Berryman C, Marston L, Moseley GL, McAuley JH, O'Connell NE
Institution:Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.; Department of Health Sciences, Centre for Health and Wellbeing Across the Lifecourse, Brunel University London, Uxbridge, UK.
Journal:Cochrane Database Syst Rev. 2023 Jun 12;6(6):CD009416. doi: 10.1002/14651858.CD009416.pub3.

2:Prednisolone 20 mg vs 40 mg in complex regional pain syndrome type I: A randomized controlled trial.
Authors:Kalita J, Pandey PC, Shukla R, Misra UK
Institution:Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226014, India. Electronic address:
Journal:J Clin Neurosci. 2023 Jul;113:108-113. doi: 10.1016/j.jocn.2023.05.017. Epub 2023 May 29.

3:Ketamine for Complex Regional Pain Syndrome: A Narrative Review Highlighting Dosing Practices and Treatment Response.
Authors:Lii TR, Singh V
Institution:Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, 450 Broadway Street, MC6343, Redwood City, CA 94063, USA.; Department of Anesthesiology, Emory University, 550 Peachtree Street, Emory University Hospital Midtown, Atlanta, GA 30308, USA. Electronic address:
Journal:Anesthesiol Clin. 2023 Jun;41(2):357-369. doi: 10.1016/j.anclin.2023.03.005. Epub 2023 Apr 14.

4:Descriptive assessment of 54 cases with complex regional pain syndrome in lower limbs.
Authors:Mana DL, Macklin Vadell A, Abdala R, Sarli M, Nakutny R, Zanchetta MB
Institution:Instituto de Investigaciones Metabolicas (IDIM), Buenos Aires, Argentina. E-mail:
Journal:Medicina (B Aires). 2023;83(2):256-263.

5:Complex regional pain syndrome: diagnosis and management.
Authors:Rose E
Institution:Institute of Health, University of Cumbria, Lancaster, England.
Journal:Nurs Stand. 2023 Apr 5;38(4):57-61. doi: 10.7748/ns.2023.e11968. Epub 2023 Mar 20.

6:The Effectiveness of Rehabilitation Interventions on Pain and Disability for Complex Regional Pain Syndrome: A Systematic Review and Meta-analysis.
Authors:Shafiee E, MacDermid J, Packham T, Walton D, Grewal R, Farzad M
Institution:Department of Health and Rehabilitation Sciences School of Physical Therapy.; Department of Health and Rehabilitation Sciences School of Physical Therapy, University of Western Ontario.
Journal:Clin J Pain. 2023 Feb 1;39(2):91-105. doi: 10.1097/AJP.0000000000001089.

7:Gamma Knife Central Lateral Thalamotomy for Chronic Neuropathic Pain: A Single-Center, Retrospective Study.
Authors:Franzini A, Ninatti G, Rossini Z, Tropeano MP, Clerici E, Navarria P, Pessina F, Picozzi P
Institution:Department of Neurosurgery, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Journal:Neurosurgery. 2023 Feb 1;92(2):363-369. doi: 10.1227/neu.0000000000002211. Epub 2022 Nov 10.

8:Complex regional pain syndrome after mRNA-based COVID-19 vaccination.
Authors:Horisawa S, Ando T, Kawamata T, Taira T
Institution:Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan. Electronic address:
Journal:Clin Neurol Neurosurg. 2023 Jan;224:107578. doi: 10.1016/j.clineuro.2022.107578. Epub 2022 Dec 28.

9:Harmful or safe? Exposure and pain provocation during physiotherapy of complex regional pain syndrome I: a narrative review.
Authors:Kavka T
Journal:J Back Musculoskelet Rehabil. 2023;36(3):565-576. doi: 10.3233/BMR-220081.

10:Biological and psychological early prognostic factors in complex regional pain syndrome: A systematic review.
Authors:Louis MH, Meyer C, Legrain V, Berquin A
Institution:Institute of Neuroscience, Universite catholique de Louvain, Brussels, Belgium.
Journal:Eur J Pain. 2023 Mar;27(3):338-352. doi: 10.1002/ejp.2068. Epub 2022 Dec 25.

11:Molecular and clinical markers of pain relief in complex regional pain syndrome: An observational study.
Authors:Reinhold AK, Kindl GK, Dietz C, Scheu N, Mehling K, Brack A, Birklein F, Rittner HL
Institution:Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Center for Interdisciplinary Pain Medicine, University Hospital Wurzburg, Wurzburg, Germany.
Journal:Eur J Pain. 2023 Feb;27(2):278-288. doi: 10.1002/ejp.2058. Epub 2022 Dec 14.

12:Olfaction in Complex Regional Pain Syndrome.
Authors:Finch PM, Sohrabi HR, Drummond PD
Institution:Centre for Healthy Ageing and Discipline of Psychology, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, Australia.
Journal:Pain Med. 2023 Jun 1;24(6):618-624. doi: 10.1093/pm/pnac180.

13:Amputation for Complex Regional Pain Syndrome: Meta-Analysis and Validation of a Histopathology Scoring System.
Authors:Howard EL, Singleton M, Soulakvelidze I
Institution:Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, Washington, USA.
Journal:Pain Med. 2023 Apr 3;24(4):425-441. doi: 10.1093/pm/pnac168.

14:Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study.
Authors:Cohen SP, Khunsriraksakul C, Yoo Y, Parker E, Samen-Akinsiku CDK, Patel N, Cohen SJ, Yuan X, Cheng J, Moon JY
Institution:Departments of Anesthesiology & Critical Care Medicine, Neurology, Physical Medicine & Rehabilitation, and Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.; Department of Anesthesiology, Seoul National University, Seoul, Korea.
Journal:Pain Med. 2023 Mar 1;24(3):316-324. doi: 10.1093/pm/pnac153.

15:Allodynia, Hyperalgesia, (Quantitative) Sensory Testing and Conditioned Pain Modulation in Patients With Complex Regional Pain Syndrome Before and After Spinal Cord Stimulation Therapy.
Authors:Kriek N, de Vos CC, Groeneweg JG, Baart SJ, Huygen FJPM
Institution:Center for Pain Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address:; Center for Pain Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Journal:Neuromodulation. 2023 Jan;26(1):78-86. doi: 10.1016/j.neurom.2022.06.009. Epub 2022 Aug 30.

16:Auditory disturbances in patients with complex regional pain syndrome.
Authors:Drummond PD, Finch PM
Institution:Discipline of Psychology, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Australia.
Journal:Pain. 2023 Apr 1;164(4):804-810. doi: 10.1097/j.pain.0000000000002766. Epub 2022 Aug 24.

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