| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Lymphocytic Leukemia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Lymphocytic Leukemia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Lymphocytic Leukemia. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Lymphocytic Leukemia every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Hampel PJ, Parikh SA |
| Institution: | Division of Hematology, Mayo Clinic, Rochester, MN, USA. parikh.sameer@mayo.edu. | | Journal: | Blood Cancer J. 2022 Nov 29;12(11):161. doi: 10.1038/s41408-022-00756-9. |
| Authors: | Rhodes JM, Barrientos JC, Rai KR |
| Institution: | Division of Hematology-Oncology, Department of Medicine at Zucker School of Medicine at Hofstra/Northwell, CLL Research and Treatment Center, 410 Lakeville Road, Suite 212, Lake Success, NY, 11042, USA. jrhodes3@northwell.edu. | | Journal: | Curr Oncol Rep. 2022 Dec;24(12):1705-1713. doi: 10.1007/s11912-022-01322-z. Epub 2022 Nov 5. |
| Authors: | Robbe P, Ridout KE, Vavoulis DV, Dréau H, Kinnersley B, Denny N, Chubb D, Appleby N, Cutts A, Cornish AJ, Lopez-Pascua L, Clifford R, Burns A, Stamatopoulos B, Cabes M, Alsolami R, Antoniou P, Oates M, Cavalieri D, Gibson J, Prabhu AV, Schwessinger R, Jennings D, James T, Maheswari U, Duran-Ferrer M, Carninci P, Knight SJL, Månsson R, Hughes J, Davies J, Ross M, Bentley D, Strefford JC, Devereux S, Pettitt AR, Hillmen P, Caulfield MJ, Houlston RS, Martín-Subero JI, Schuh A |
| Institution: | Department of Oncology, University of Oxford, Oxford, UK. anna.schuh@oncology.ox.ac.uk. | | Journal: | Nat Genet. 2022 Nov;54(11):1675-1689. doi: 10.1038/s41588-022-01211-y. Epub 2022 Nov 4. |
| Authors: | Gu D, Li J, Miao Y |
| Institution: | Pukou CLL Center, Pukou Division of Jiangsu Province Hospital, Nanjing, Jiangsu, China. | | Journal: | Expert Opin Pharmacother. 2022 Dec;23(18):1979-1986. doi: 10.1080/14656566.2022.2144218. Epub 2022 Nov 11. |
| Authors: | Deering KL, Sundaram M, Harshaw Q, Trudeau J, Barrientos JC |
| Institution: | EPI-Q, Inc., Oak Brook, Illinois, United States of America.; Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida, United States of America. | | Journal: | PLoS One. 2022 Oct 6;17(10):e0270291. doi: 10.1371/journal.pone.0270291. eCollection 2022. |
| Authors: | Woyach JA |
| Institution: | Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. | | Journal: | Am J Hematol. 2022 Nov;97 Suppl 2:S11-S18. doi: 10.1002/ajh.26683. |
| Authors: | Kutsch N, Fink AM, Fischer K |
| Institution: | Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne, Duesseldorf and German CLL Study Group, University of Cologne, Cologne, Germany. | | Journal: | Am J Hematol. 2022 Nov;97 Suppl 2:S3-S10. doi: 10.1002/ajh.26677. |
| Authors: | Hampel PJ, Rabe KG, Call TG, Ding W, Leis JF, Chanan-Khan AA, Kenderian SS, Muchtar E, Wang Y, Ailawadhi S, Koehler AB, Parrondo R, Schwager SM, Sher T, Hanson CA, Shi M, Van Dyke DL, Braggio E, Slager SL, Kay NE, Parikh SA |
| Institution: | Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. parikh.sameer@mayo.edu. | | Journal: | Blood Cancer J. 2022 Sep 1;12(9):124. doi: 10.1038/s41408-022-00721-6. |
| Authors: | Antic D, Milic N, Chatzikonstantinou T, Scarfò L, Otasevic V, Rajovic N, Allsup D, Alonso Cabrero A, Andres M, Baile Gonzales M, Capasso A, Collado R, Cordoba R, Cuéllar-García C, Correa JG, De Paoli L, De Paolis MR, Del Poeta G, Dimou M, Doubek M, Efstathopoulou M, El-Ashwah S, Enrico A, Espinet B, Farina L, Ferrari A, Foglietta M, Lopez-Garcia A, García-Marco JA, García-Serra R, Gentile M, Gimeno E, da Silva MG, Gutwein O, Hakobyan YK, Herishanu Y, Hernández-Rivas JÁ, Herold T, Itchaki G, Jaksic O, Janssens A, Kalashnikova OB, Kalicińska E, Kater AP, Kersting S, Koren-Michowitz M, Labrador J, Lad D, Laurenti L, Fresa A, Levin MD, Mayor Bastida C, Malerba L, Marasca R, Marchetti M, Marquet J, Mihaljevic B, Milosevic I, Mirás F, Morawska M, Motta M, Munir T, Murru R, Nunes R, Olivieri J, Pavlovsky MA, Piskunova I, Popov VM, Quaglia FM, Quaresmini G, Reda G, Rigolin GM, Shrestha A, Šimkovič M, Smirnova S, Špaček M, Sportoletti P, Stanca O, Stavroyianni N, Te Raa D, Tomic K, Tonino S, Trentin L, Van Der Spek E, van Gelder M, Varettoni M, Visentin A, Vitale C, Vukovic V, Wasik-Szczepanek E, Wróbel T, Segundo LYS, Yassin M, Coscia M, Rambaldi A, Montserrat E, Foà R, Cuneo A, Carrier M, Ghia P, Stamatopoulos K |
| Institution: | Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia. darko.antic1510976@gmail.com.; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece. | | Journal: | J Hematol Oncol. 2022 Aug 26;15(1):116. doi: 10.1186/s13045-022-01333-0. |
| Authors: | Perutelli F, Montalbano MC, Boccellato E, Coscia M, Vitale C |
| Institution: | University Division of Hematology, A.O.U. Citta della Salute e della Scienza di Torino. | | Journal: | Curr Opin Oncol. 2022 Nov 1;34(6):757-767. doi: 10.1097/CCO.0000000000000897. Epub 2022 Aug 22. |
| Authors: | Paulus A, Malavasi F, Chanan-Khan A |
| Institution: | Department of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL, USA. | | Journal: | Leuk Lymphoma. 2022 Oct;63(10):2265-2275. doi: 10.1080/10428194.2022.2090551. Epub 2022 Aug 17. |
| Authors: | Hatashima A, Karami M, Shadman M |
| Institution: | Department of Pharmacy, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. | | Journal: | Expert Opin Pharmacother. 2022 Sep;23(13):1545-1557. doi: 10.1080/14656566.2022.2113384. Epub 2022 Aug 22. |
| Authors: | Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, Giró A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, González M, Climent F, Abrisqueta P, Castellví J, Bosch F, Aymerich M, Enjuanes A, Ruiz-Gaspà S, López-Guillermo A, Jares P, Beà S, Capella-Gutierrez S, Gelpí JL, López-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, Martín-Subero JI, Campo E |
| Institution: | Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. nadeu@recerca.clinic.cat.; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. ecampo@clinic.cat. | | Journal: | Nat Med. 2022 Aug;28(8):1662-1671. doi: 10.1038/s41591-022-01927-8. Epub 2022 Aug 11. |
| Authors: | Wen Y, Meng L, Zhang X, Gao Q |
| Institution: | Department of Basic Medicine, Center of Translational Medicine, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu, China. | | Journal: | Expert Rev Hematol. 2022 Sep;15(9):849-856. doi: 10.1080/17474086.2022.2110062. Epub 2022 Aug 9. |
| Authors: | Kuss B, Nagarajan C, Hsieh WS, Cheah CY |
| Institution: | Molecular Medicine and Genetics, Flinders University, Adelaide, SA, Australia.; University of Western Australia Medical School, University of Western Australia, Perth, WA, Australia. | | Journal: | Leuk Lymphoma. 2022 Dec;63(12):2785-2794. doi: 10.1080/10428194.2022.2098289. Epub 2022 Jul 19. |
| Authors: | Omi A, Nomura F, Tsujioka S, Fujino A, Akizuki R |
| Institution: | Medical Affairs Division, Janssen Pharmaceutical K.K., Tokyo, Japan. | | Journal: | J Clin Exp Hematop. 2022 Sep 28;62(3):136-146. doi: 10.3960/jslrt.22002. Epub 2022 Jul 12. |
| Authors: | Awan FT, Addison D, Alfraih F, Baratta SJ, Campos RN, Cugliari MS, Goh YT, Ionin VA, Mundnich S, Sverdlov AL, Tam C, Ysebaert L |
| Institution: | Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX.; Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France. | | Journal: | Blood Adv. 2022 Sep 27;6(18):5516-5525. doi: 10.1182/bloodadvances.2022007938. |
| Authors: | Yu TY, Jhou HJ, Chen PH, Lee CH |
| Institution: | Division of Hematology and Oncology Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan. | | Journal: | Curr Oncol. 2022 Jun 14;29(6):4245-4259. doi: 10.3390/curroncol29060339. |
| Authors: | Todorovic Z, Todorovic D, Markovic V, Ladjevac N, Zdravkovic N, Djurdjevic P, Arsenijevic N, Milovanovic M, Arsenijevic A, Milovanovic J |
| Institution: | Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia. | | Journal: | Curr Oncol. 2022 May 18;29(5):3647-3657. doi: 10.3390/curroncol29050293. |
| Authors: | Huang Q, Deering KL, Harshaw Q, Leslie LA |
| Institution: | Janssen Scientific Affairs, LLC, Horsham, PA, USA.; John Theurer Cancer Center, Hackensack, NJ, USA. | | Journal: | Adv Ther. 2022 Jul;39(7):3292-3307. doi: 10.1007/s12325-021-01991-5. Epub 2022 May 24. |
| Authors: | Niemann CU, da Cunha-Bang C, Helleberg M, Ostrowski SR, Brieghel C |
| Institution: | Department of Hematology, Rigshospitalet, Copenhagen, Denmark. | | Journal: | Blood. 2022 Aug 4;140(5):445-450. doi: 10.1182/blood.2022016147. |
| Authors: | Burke JM |
| Institution: | Rocky Mountain Cancer Centers, Aurora, CO. Electronic address: john.burke@usoncology.com. | | Journal: | Clin Lymphoma Myeloma Leuk. 2022 Jul;22(7):427-435. doi: 10.1016/j.clml.2022.04.017. Epub 2022 Apr 22. |
| Authors: | Desikan SP, Venugopal S, Ferrajoli A |
| Institution: | Departments of Leukemia, The University of Texas Houston, Texas, USA. | | Journal: | Expert Rev Hematol. 2022 May;15(5):403-409. doi: 10.1080/17474086.2022.2074393. Epub 2022 May 11. |
| Authors: | Gordon MJ, Ferrajoli A |
| Institution: | MD Anderson Cancer Center, University of Texas, Houston, Texas, USA. | | Journal: | Am J Hematol. 2022 Nov;97 Suppl 2:S26-S34. doi: 10.1002/ajh.26585. Epub 2022 May 12. |
| Authors: | Mato AR, Tang B, Azmi S, Yang K, Zhang X, Stern JC, Hedrick E, Huang J, Sharman JP |
| Institution: | Memorial Sloan Kettering Cancer Center, New York. matoa@mskcc.org.; Willamette Valley Cancer Institute / US Oncology Research, Eugene. | | Journal: | Haematologica. 2022 Nov 1;107(11):2630-2640. doi: 10.3324/haematol.2021.280376. |
| Authors: | Wiedmeier-Nutor J, Leis J |
| Institution: | Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA. Wiedmeier.julia@mayo.edu. | | Journal: | Curr Treat Options Oncol. 2022 Jun;23(6):904-919. doi: 10.1007/s11864-022-00953-5. Epub 2022 Apr 18. |
| Authors: | Shanafelt TD, Wang XV, Hanson CA, Paietta EM, O'Brien S, Barrientos J, Jelinek DF, Braggio E, Leis JF, Zhang CC, Coutre SE, Barr PM, Cashen AF, Mato AR, Singh AK, Mullane MP, Little RF, Erba H, Stone RM, Litzow M, Tallman M, Kay NE |
| Institution: | Stanford University, Stanford, CA.; Mayo Clinic, Rochester, MN. | | Journal: | Blood. 2022 Jul 14;140(2):112-120. doi: 10.1182/blood.2021014960. |
| Authors: | Rivera D, Ferrajoli A |
| Institution: | Department of Leukemia, The University of Texas-MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 0428, Houston, TX, 77030, USA. aferrajo@mdanderson.org. | | Journal: | Curr Oncol Rep. 2022 Aug;24(8):1003-1014. doi: 10.1007/s11912-022-01261-9. Epub 2022 Apr 2. |
| Authors: | Iskierka-Jażdżewska E, Obracaj A, Urbaniak M, Robak T |
| Institution: | Department of General Hematology, Copernicus Memorial Hospital, Lodz, Poland. tadeusz.robak@umed.lodz.pl. | | Journal: | Curr Treat Options Oncol. 2022 Jun;23(6):775-795. doi: 10.1007/s11864-022-00974-0. Epub 2022 Mar 31. |
| Authors: | Gill S, Vides V, Frey NV, Hexner EO, Metzger S, O'Brien M, Hwang WT, Brogdon JL, Davis MM, Fraietta JA, Gaymon AL, Gladney WL, Lacey SF, Lamontagne A, Mato AR, Maus MV, Melenhorst JJ, Pequignot E, Ruella M, Shestov M, Byrd JC, Schuster SJ, Siegel DL, Levine BL, June CH, Porter DL |
| Institution: | Cell Therapy and Transplant Program, Division of Hematology-Oncology and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA. | | Journal: | Blood Adv. 2022 Nov 8;6(21):5774-5785. doi: 10.1182/bloodadvances.2022007317. |
| Authors: | Molica S, Tam C, Polliack A |
| Institution: | Department of Hematology, Hull University Teaching Hospitals NHS Trust, Hull, UK.; Department of Hematology, Hadassah-Hebrew-University Medical Center, Jerusalem, Israel. | | Journal: | Hematol Oncol. 2022 Aug;40(3):313-319. doi: 10.1002/hon.2990. Epub 2022 Mar 23. |
| Authors: | Tettamanti S, Rotiroti MC, Giordano Attianese GMP, Arcangeli S, Zhang R, Banerjee P, Galletti G, McManus S, Mazza M, Nicolini F, Martinelli G, Ivan C, Veliz Rodriguez T, Barbaglio F, Scarfò L, Ponzoni M, Wierda W, Gandhi V, Keating M, Biondi A, Caligaris-Cappio F, Biagi E, Ghia P, Bertilaccio MTS |
| Institution: | Centro Ricerca Tettamanti, Clinica Pediatrica, Universita Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza, Italy.; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. | | Journal: | Leuk Lymphoma. 2022 Jul;63(7):1566-1579. doi: 10.1080/10428194.2022.2043299. Epub 2022 Mar 8. |
| Authors: | Akhtar OS, Groman A, Singh A, Ghione P, Lund I, Hernandez-Ilizaliturri FJ, Torka P |
| Institution: | Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. | | Journal: | Leuk Lymphoma. 2022 May;63(5):1127-1136. doi: 10.1080/10428194.2021.2012662. Epub 2022 Feb 13. |
| Authors: | Harris V, Borlagdan J, Muluneh B |
| Institution: | Pharmacy, 427363Novant Health Presbyterian Medical Centre, 200 Hawthorne Ln, Charlotte, NC, USA 28204.; 15521UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA. | | Journal: | J Oncol Pharm Pract. 2022 Jun;28(4):935-944. doi: 10.1177/10781552211073906. Epub 2022 Jan 27. |
| Authors: | Moreno C, Greil R, Demirkan F, Tedeschi A, Anz B, Larratt L, Simkovic M, Novak J, Strugov V, Gill D, Gribben JG, Kwei K, Dai S, Hsu E, Dean JP, Flinn IW |
| Institution: | Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain. cmorenoa@santpau.cat.; Sarah Cannon Research Institute, Nashville, TN, USA. | | Journal: | Haematologica. 2022 Sep 1;107(9):2108-2120. doi: 10.3324/haematol.2021.279012. |
| Authors: | Brown JR, Byrd JC, Ghia P, Sharman JP, Hillmen P, Stephens DM, Sun C, Jurczak W, Pagel JM, Ferrajoli A, Patel P, Tao L, Kuptsova-Clarkson N, Moslehi J, Furman RR |
| Institution: | Dana-Farber Cancer Institute, Boston, MA. jennifer_brown@dfci.harvard.edu.; Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY. | | Journal: | Haematologica. 2022 Jun 1;107(6):1335-1346. doi: 10.3324/haematol.2021.278901. |
| Authors: | Tang X, Zou W, Peng P, Bai Y |
| Institution: | Department of Hematology, Mianyang 404 Hospital, Mianyang, 621000, Sichuan Province, China. Sylvia1227@126.com. | | Journal: | Clin Exp Med. 2022 May;22(2):161-171. doi: 10.1007/s10238-021-00739-3. Epub 2021 Jul 5. |
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