Meniere's Disease
March 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Meniere's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Meniere's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Meniere's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Meniere's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Speech Recognition During Follow-Up of Patients with Ménière's Disease: What Are We Missing?
Authors:Garaycochea O, Manrique-Huarte R, Calavia D, Girón L, Pérez-Fernández N
Institution:Department of Otorhinolaryngology, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain.
Journal:J Int Adv Otol. 2022 Jan;18(1):14-19. doi: 10.5152/iao.2022.20016.

2:Update on diagnosis and differential diagnosis of vestibular migraine.
Authors:Shen Y, Qi X
Institution:Zhujiang Hospital (The Second School of Clinical Medicine), Southern Medical University, Guangzhou, 510515, Guangdong, China.
Journal:Neurol Sci. 2022 Mar;43(3):1659-1666. doi: 10.1007/s10072-022-05872-9. Epub 2022 Jan 11.

3:A comparison of endolymphatic duct blockage, endolymphatic sac drainage and endolymphatic sac decompression surgery in reversing endolymphatic hydrops in Meniere's disease.
Authors:Peng A, Hu J, Wang Q, Pan X, Zhang Z, Jiang W, Chen Y, Huang C
Institution:Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Journal:J Otolaryngol Head Neck Surg. 2021 Dec 20;50(1):70. doi: 10.1186/s40463-021-00545-7.

4:Vestibular function testing in the 21st century: video head impulse test, vestibular evoked myogenic potential, video nystagmography; which tests will provide answers?
Authors:Rosengren SM, Young AS, Taylor RL, Welgampola MS
Institution:Central Clinical School, Faculty of Medicine and Health, University of Sydney.
Journal:Curr Opin Neurol. 2022 Feb 1;35(1):64-74. doi: 10.1097/WCO.0000000000001023.

5:Ménière's disease: new guidelines, subtypes, imaging, and more.
Authors:Hoskin JL
Institution:Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.
Journal:Curr Opin Neurol. 2022 Feb 1;35(1):90-97. doi: 10.1097/WCO.0000000000001021.

6:Vestibular and auditory manifestations of migraine.
Authors:Benjamin T, Gillard D, Abouzari M, Djalilian HR, Sharon JD
Institution:University of California, San Francisco (UCSF) Department of Otolaryngology - Head and Neck Surgery, San Francisco.
Journal:Curr Opin Neurol. 2022 Feb 1;35(1):84-89. doi: 10.1097/WCO.0000000000001024.

7:Personality and psychopathology in Ménière's disease.
Authors:Correia F, Medeiros AB, Castelhano L, Cavilhas P, Escada P
Institution:Servico de Otorrinolaringologia, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal; Nova Medical School, Universidade Nova, Lisboa, Portugal. Electronic address:
Journal:Acta Otorrinolaringol Esp (Engl Ed). 2021 Nov-Dec;72(6):344-351. doi: 10.1016/j.otoeng.2020.06.010.

8:Triple semicircular canal occlusion: a surgical perspective with short- and long-term outcomes.
Authors:Kontorinis G, Thachil G
Institution:Department of Otorhinolaryngology - Head and Neck Surgery, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
Journal:J Laryngol Otol. 2022 Feb;136(2):125-128. doi: 10.1017/S002221512100387X. Epub 2021 Nov 29.

9:Long-term effect of transtympanic intermittent pressure therapy using a tympanic membrane massage device for intractable meniere's disease and delayed endolymphatic hydrops.
Authors:Shojaku H, Takakura H, Asai M, Fujisaka M, Ueda N, Do TA, Tsubota M, Watanabe Y
Institution:Department of Otolaryngology, University of Toyama, Toyama, Japan.
Journal:Acta Otolaryngol. 2021 Nov;141(11):977-983. doi: 10.1080/00016489.2021.1989485. Epub 2021 Oct 24.

10:Quantification of endolymphatic hydrops and its correlation with Meniere's disease clinical features.
Authors:Sun Q, Jiang G, Xiong G, Sun W, Wen W, Wei F
Institution:Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. University, Guangzhou, China. University, Guangzhou, China. University, Guangzhou, China. University, Guangzhou, China. University, Guangzhou, China.
Journal:Clin Otolaryngol. 2021 Nov;46(6):1354-1361. doi: 10.1111/coa.13847. Epub 2021 Aug 20.

11:Differences in responsiveness of intratympanic steroid injection for intractable vertigo in Meniere's disease.
Authors:Okuda H, Aoki M, Ogawa B, Shibata H, Ueda N, Ohashi T, Hayashi H, Nishihori T, Kuze B, Ogawa T
Institution:Department of Otolaryngology, Gifu University School of Medicine, Japan. Healthcare Information Technology, Tokai National Higher Education and Research System, Japan. address:
Journal:Am J Otolaryngol. 2021 Nov-Dec;42(6):103141. doi: 10.1016/j.amjoto.2021.103141. Epub 2021 Jun 18.

12:Intratympanic steroid versus gentamicin for treatment of refractory Meniere's disease: A meta-analysis.
Authors:Lee SY, Kim YS, Jeong B, Carandang M, Koo JW, Oh SH, Lee JH
Institution:Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Hospital, Seoul, Republic of Korea. Metro Manila, Philippines. Bundang Hospital, Seongnam, Republic of Korea. Hospital, Seoul, Republic of Korea. Hospital, Seoul, Republic of Korea. Electronic address:
Journal:Am J Otolaryngol. 2021 Nov-Dec;42(6):103086. doi: 10.1016/j.amjoto.2021.103086. Epub 2021 May 21.

13:Vertigo without cochlear symptoms: vestibular migraine or Menière disease?
Authors:Teggi R, Familiari M, Gatti O, Bussi M
Institution:Department of Otolaryngology Head & Neck Surgery, IRCCS San Raffaele Scientific Institute, San Raffaele Hospital, Via Olgettina 60, 20132, Milan, Italy.
Journal:Neurol Sci. 2021 Dec;42(12):5071-5076. doi: 10.1007/s10072-021-05215-0. Epub 2021 Mar 25.

14:Association Between Serum Vitamin D Level and Ménière's Disease.
Authors:Bakhshaee M, Moradi S, Mohebi M, Ghayour-Mobarhan M, Sharifan P, Yousefi R, Rezaei A, Rajati M
Institution:Ghaem University Hospital, Sinus and Surgical Endoscopic Research Center, Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal:Otolaryngol Head Neck Surg. 2022 Jan;166(1):146-150. doi: 10.1177/01945998211000395. Epub 2021 Mar 23.

15:Evaluation of vestibular function following endolymphatic sac surgery.
Authors:Gendre A, Bourget-Aguilar K, Calais C, Espitalier F, Bordure P, Michel G
Institution:Service d'ORL et de Chirurgie Cervico-Faciale, Centre Hospitalier Universitaire de Nantes (CHU), Hotel-Dieu, 1, Place A. Ricordeau, BP 1005, 44093, Nantes Cedex 01, France.
Journal:Eur Arch Otorhinolaryngol. 2022 Mar;279(3):1193-1201. doi: 10.1007/s00405-021-06743-3. Epub 2021 Mar 19.

16:Effects of intratympanic gentamicin and intratympanic glucocorticoids in Ménière's disease: a network meta-analysis.
Authors:Hao W, Yu H, Li H
Institution:ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China.
Journal:J Neurol. 2022 Jan;269(1):72-86. doi: 10.1007/s00415-020-10320-9. Epub 2021 Jan 2.

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