Sjogren's Syndrome
November 2019 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:B cell depletion with rituximab in the treatment of primary Sjogren's syndrome: what have we learnt?
Authors:Grigoriadou S, Chowdhury F, Pontarini E, Tappuni A, Bowman SJ, Bombardieri M
Institution:Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, UK. m.bombardieri@qmul.ac.uk.; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, and Department of Oral Medicine, Institute of Dentistry, Bart's and The London School of Medicine and Dentistry, Queen Mary University of London, UK.; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, and Rheumatology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):217-224. Epub 2019 Aug 28.

2:Double anti-B cell and anti-BAFF targeting for the treatment of primary Sjogren's syndrome.
Authors:Gandolfo S, De Vita S
Institution:Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Italy. University of Udine, Italy. salvatore.devita@asuiud.sanita.fvg.it.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):199-208. Epub 2019 Jul 22.

3:The kaleidoscope of neurological manifestations in primary Sjogren's syndrome.
Authors:Alunno A, Carubbi F, Bartoloni E, Cipriani P, Giacomelli R, Gerli R
Institution:Rheumatology Unit, Department of Medicine, University of Perugia, Italy. University of L'Aquila, and Department of Medicine, ASL 1 Avezzano-Sulmona-L'Aquila, Italy. University of L'Aquila, Italy. University of L'Aquila, Italy. roberto.gerli@unipg.it.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):192-198. Epub 2019 Aug 28.

4:One year in review 2019: Sjogren's syndrome.
Authors:Cafaro G, Croia C, Argyropoulou OD, Leone MC, Orlandi M, Finamore F, Cecchettini A, Ferro F, Baldini C, Bartoloni E
Institution:Rheumatology Unit, Department of Medicine, University of Perugia, Italy. University of Pisa, Italy. University of Athens, Greece. of Florence, Italy. of Pisa, Italy. of Pisa, Italy. chiara.baldini74@gmail.com.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):3-15. Epub 2019 Jul 16.

5:Genetics in Sjogren's syndrome: where we are and where we go.
Authors:Harris VM, Scofield RH, Sivils KL
Institution:Arthritis & Clin. Immunology Program, Oklahoma Med. Research Foundation; Depts. of Medicine and Pathology, College of Medicine, Univ. of Oklahoma Health Sciences Center; Research & Medical Services, Oklahoma City US Dept. of Veterans Affairs Center, USA. sivilsk@omrf.org.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):234-239. Epub 2019 Aug 28.

6:Renal involvement in primary Sjogren's syndrome: natural history and treatment outcome.
Authors:Goules A, Geetha D, Arend LJ, Baer AN
Institution:Jerome L. Greene Sjogren's Syndrome Center, Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Present address: National and Kapodistrian University of Athens, Greece. agoules@med.uoa.gr. Hopkins School of Medicine, Baltimore, MD, USA.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):123-132. Epub 2019 Aug 28.

7:Systemic manifestations of primary Sjogren's syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients.
Authors:Retamozo S, Acar-Denizli N, Rasmussen A, Horvath IF, Baldini C, Priori R, Sandhya P, Hernandez-Molina G, Armagan B, Praprotnik S, Kvarnstrom M, Gerli R, Sebastian A, Solans R, Rischmueller M, Pasoto SG, Valim V, Nordmark G, Kruize A, Nakamura H, Hofauer B, Giacomelli R, Fernandes Moca Trevisani V, Devauchelle-Pensec V, Atzeni F, Gheita TA, Consani-Fernandez S, Szanto A, Sivils K, Gattamelata A, Danda D, Kilic L, Bartoloni E, Bombardieri S, Sanchez-Guerrero J, Wahren-Herlenius M, Mariette X, Ramos-Casals M, Brito-Zeron P
Institution:Inst. De Investigaciones En Ciencias De La Salud (INICSA), Universidad Nacional de Cordoba (UNC), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Cordoba, and Inst. Universitario de Ciencias Biomedicas de Cordoba (IUCBC), Argentina.; Department of Statistics, Faculty of Science and Letters, Mimar Sinan Fine Arts University, Istanbul, Turkey.; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.; Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Hungary.; Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):97-106. Epub 2019 Aug 28.

8:Clinical efficacy of low-dose rituximab on hematological abnormalities in patients with connective tissue disease.
Authors:Wang CY, Guo SH, Wang LP, Wang XY, Shen HL
Journal:Int J Clin Pharmacol Ther. 2019 Oct;57(10):500-505. doi: 10.5414/CP203453.

9:The use of self-retained, cryopreserved amniotic membrane for the treatment of Sjogren syndrome: a case series.
Authors:Shafer B, Fuerst NM, Massaro-Giordano M, Palladino V, Givnish T, Macchi I, Sulewski ME, Orlin SE, Bunya VY
Institution:Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia.
Journal:Digit J Ophthalmol. 2019 Jun 8;25(2):21-25. doi: 10.5693/djo.01.2019.02.005. eCollection 2019.

10:Trends in employment and hospitalisation in patients with Sjogren's syndrome 1996-2016: results from the German National database.
Authors:Callhoff J, Thiele K, Dorner T, Zink A, Richter JG, Henes J, Albrecht K
Institution:German Rheumatism Research Centre, Epidemiology Unit, Berlin, Germany. johanna.callhoff@drfz.de. University Medicine Berlin, Germany. Rheumatology & Hiller Research Centre for Rheumatology, Duesseldorf, Germany. Immunology, Tuebingen, Germany.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):83-89. Epub 2019 Jul 3.

11:Evaluation of salivary gland ultrasonography in primary Sjogren's syndrome: does it reflect clinical activity and outcome of the disease?
Authors:Inanc N, Sahinkaya Y, Mumcu G, Ture Ozdemir F, Paksoy A, Erturk Z, Direskeneli H, Bruyn GA
Institution:Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. inanc.nevsun@gmail.com. Turkey. Istanbul, Turkey. Turkey. Turkey.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):140-145. Epub 2019 Jul 5.

12:Present and novel biologic drugs in primary Sjogren's syndrome.
Authors:Fasano S, Isenberg DA
Institution:Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Campania L. Vanvitelli, Naples, Italy. serena.fasano@unicampania.it.
Journal:Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):167-174. Epub 2019 Apr 26.

13:The pipeline of targeted therapies under clinical development for primary Sjogren's syndrome: A systematic review of trials.
Authors:Felten R, Scher F, Sibilia J, Gottenberg JE, Arnaud L
Institution:Service de rhumatologie, Hopitaux Universitaires de Strasbourg, F-67000 Strasbourg, France.; Laboratoire d'Immunologie, Immunopathologie et Chimie Therapeutique, Institut de Biologie Moleculaire et Cellulaire (IBMC), CNRS UPR3572, France; RESO : Centre de Reference des Maladies Autoimmunes Systemiques Rares Est Sud-Ouest, France.; Service de Pharmacie-Sterilisation, Hopitaux Universitaires de Strasbourg, France.; Service de rhumatologie, Hopitaux Universitaires de Strasbourg, F-67000 Strasbourg, France.; RESO : Centre de Reference des Maladies Autoimmunes Systemiques Rares Est Sud-Ouest, France; INSERM UMR_S1109, Universite de Strasbourg, F-67000 Strasbourg, France. Electronic address: Laurent.arnaud@chru-strasbourg.fr.
Journal:Autoimmun Rev. 2019 Jun;18(6):576-582. doi: 10.1016/j.autrev.2018.12.008. Epub 2019 Apr 6.

14:Sjogren's Syndrome: More Than Just Dry Eye.
Authors:Akpek EK, Bunya VY, Saldanha IJ
Institution:The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD. Synthesis in Health, Brown University School of Public Health, Providence, RI.
Journal:Cornea. 2019 May;38(5):658-661. doi: 10.1097/ICO.0000000000001865.

15:Effects of Xerostom((R)) products on xerostomia in primary Sjogren's syndrome: A randomized clinical trial.
Authors:Lopez-Pintor RM, Ramirez L, Serrano J, de Pedro M, Fernandez-Castro M, Casanas E, Hernandez G
Institution:Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, Spain.; Rheumatology Service, Hospital Infanta Sofia, Madrid, Spain.
Journal:Oral Dis. 2019 Apr;25(3):772-780. doi: 10.1111/odi.13019. Epub 2019 Jan 8.

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