Sjogren's Syndrome
October 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Risk factors related to oral candidiasis in patients with primary Sjögren's syndrome.
Authors:Serrano J, López-Pintor RM, Ramírez L, Fernández-Castro M, Sanz M, Melchor S, Peiteado D, Hernández G
Institution:Departamento de Especialidades Clinicas Odontologicas Facultad de Odontologia Universidad Complutense de Madrid Plaza Ramon y Cajal s/n, 28040 Madrid. Spain
Journal:Med Oral Patol Oral Cir Bucal. 2020 Sep 1;25(5):e700-e705. doi: 10.4317/medoral.23719.

2:Correlation of sleep quality with fatigue and disease activity among patients with primary Sjögren's syndrome: a cross-sectional study.
Authors:Dardin LP, Garcia ABA, Gazoni FM, Santos FCD, Mello MT, Trevisani VFM
Institution:Discipline of Emergency Medicine and Evidence-Based Medicine, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
Journal:Sao Paulo Med J. 2020 Mar;138(2):146-151. doi: 10.1590/1516-3180.2019.0251.R1.1912019. Epub 2020 Mar 9.

3:Population-based study of patients with primary Sjögren's syndrome and lymphoma: lymphoma subtypes, clinical characteristics, and gender differences.
Authors:Vasaitis L, Nordmark G, Theander E, Backlin C, Smedby KE, Askling J, Rönnblom L, Sundström C, Baecklund E
Institution:Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden.
Journal:Scand J Rheumatol. 2020 May;49(3):225-232. doi: 10.1080/03009742.2019.1696403. Epub 2020 Mar 10.

4:Sjögren Syndrome in Primary Salivary Gland Lymphoma.
Authors:Travaglino A, Giordano C, Pace M, Varricchio S, Picardi M, Pane F, Staibano S, Mascolo M
Institution:Department of Advanced Biomedical Sciences, Pathology Section, Federico II University of Naples, Naples, Italy.
Journal:Am J Clin Pathol. 2020 May 5;153(6):719-724. doi: 10.1093/ajcp/aqaa005.

5:Is the taste acuity affected by oral dryness in primary Sjögren's syndrome patients?
Authors:Al-Ezzi M, Khan K, Tappuni AR
Institution:Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Journal:Oral Dis. 2020 Apr;26(3):688-695. doi: 10.1111/odi.13259. Epub 2020 Jan 6.

6:Patient-related outcomes in Sjögren syndrome treated with stimulants of salivary secretion: Randomized clinical trial.
Authors:da Mata ADSP, Amaral JPAR, Thomson WM, Barcelos F, Vaz Patto J, Pereira RMN, Marques DNDS
Institution:Oral Biology & Biochemistry Research Group, LIBPhys-FCT UID/FIS/04559/2013, Faculdade de Medicina Dentaria, Universidade de Lisboa, Lisboa, Portugal.
Journal:Oral Dis. 2020 Mar;26(2):313-324. doi: 10.1111/odi.13251. Epub 2019 Dec 26.

7:Unique Sjögren's syndrome patient subsets defined by molecular features.
Authors:James JA, Guthridge JM, Chen H, Lu R, Bourn RL, Bean K, Munroe ME, Smith M, Chakravarty E, Baer AN, Noaiseh G, Parke A, Boyle K, Keyes-Elstein L, Coca A, Utset T, Genovese MC, Pascual V, Utz PJ, Holers VM, Deane KD, Sivils KL, Aberle T, Wallace DJ, McNamara J, Franchimont N, St Clair EW
Institution:Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. Division of Rheumatology and Immunology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Journal:Rheumatology (Oxford). 2020 Apr 1;59(4):860-868. doi: 10.1093/rheumatology/kez335.

8:Incorporation of Salivary Gland Ultrasonography Into the American College of Rheumatology/European League Against Rheumatism Criteria for Primary Sjögren's Syndrome.
Authors:van Nimwegen JF, Mossel E, Delli K, van Ginkel MS, Stel AJ, Kroese FGM, Spijkervet FKL, Vissink A, Arends S, Bootsma H
Institution:University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Journal:Arthritis Care Res (Hoboken). 2020 Apr;72(4):583-590. doi: 10.1002/acr.24017.

9:Orofacial Motor Functions and Temporomandibular Disorders in Patients With Sjögren's Syndrome.
Authors:Zanin MC, Garcia DM, Rocha EM, de Felício CM
Institution:University of Sao Paulo, Sao Paulo, Brazil.
Journal:Arthritis Care Res (Hoboken). 2020 Aug;72(8):1057-1065. doi: 10.1002/acr.24001.

10:Meta-Analysis of Treatment for Primary Sjögren's Syndrome.
Authors:Chu LL, Cui K, Pope JE
Institution:Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Schulich School of Medicine and Dentistry, Western University, and St. Joseph's Health Care, London, Ontario, Canada.
Journal:Arthritis Care Res (Hoboken). 2020 Jul;72(7):1011-1021. doi: 10.1002/acr.23917. Epub 2020 Jun 7.

11:Evaluation of the Efficacy and Safety of A Novel 0.05% Cyclosporin A Topical Nanoemulsion in Primary Sjögren's Syndrome Dry Eye.
Authors:Kang MJ, Kim YH, Chou M, Hwang J, Cheon EJ, Lee HJ, Chung SH
Institution:Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Journal:Ocul Immunol Inflamm. 2020 Apr 2;28(3):370-378. doi: 10.1080/09273948.2019.1587470. Epub 2019 Apr 15.

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