Sjogren's Syndrome
July 2019 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:The pipeline of targeted therapies under clinical development for primary Sjogren's syndrome: A systematic review of trials.
Authors:Felten R, Scher F, Sibilia J, Gottenberg JE, Arnaud L
Institution:Service de rhumatologie, Hopitaux Universitaires de Strasbourg, F-67000 Strasbourg, France.; Laboratoire d'Immunologie, Immunopathologie et Chimie Therapeutique, Institut de Biologie Moleculaire et Cellulaire (IBMC), CNRS UPR3572, France; RESO : Centre de Reference des Maladies Autoimmunes Systemiques Rares Est Sud-Ouest, France.; Service de Pharmacie-Sterilisation, Hopitaux Universitaires de Strasbourg, France.; Service de rhumatologie, Hopitaux Universitaires de Strasbourg, F-67000 Strasbourg, France.; RESO : Centre de Reference des Maladies Autoimmunes Systemiques Rares Est Sud-Ouest, France; INSERM UMR_S1109, Universite de Strasbourg, F-67000 Strasbourg, France. Electronic address: Laurent.arnaud@chru-strasbourg.fr.
Journal:Autoimmun Rev. 2019 Jun;18(6):576-582. doi: 10.1016/j.autrev.2018.12.008. Epub 2019 Apr 6.

2:Risk of Parkinson disease in Sjogren syndrome administered ineffective immunosuppressant therapies: A nationwide population-based study.
Authors:Ju UH, Liu FC, Lin CS, Huang WY, Lin TY, Shen CH, Chou YC, Lin CL, Lin KT, Kao CH, Chen CH, Yang TY
Institution:Division of Rheumatology/Immunology and Allergy. Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei. Medicine, China Medical University. University, Taichung. HsinChu County, China Medical University. University, Taichung. Taichung, Taiwan. Hospital, Changhua, Taiwan.
Journal:Medicine (Baltimore). 2019 Apr;98(14):e14984. doi: 10.1097/MD.0000000000014984.

3:High-Risk Indicators of Renal Involvement in Primary Sjogren's Syndrome: A Clinical Study of 1002 Cases.
Authors:Luo J, Huo YW, Wang JW, Guo H
Institution:Division of Rheumatology, Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China. Medical University, Taiyuan, Shanxi 030001, China. Medical University, Taiyuan, Shanxi 030001, China. Medical University, Taiyuan, Shanxi 030001, China. Hospital, Shenzhen, Guangdong 518005, China.
Journal:J Immunol Res. 2019 Feb 17;2019:3952392. doi: 10.1155/2019/3952392. eCollection 2019.

4:Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren's Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study.
Authors:Ben-Eli H, Aframian DJ, Ben-Chetrit E, Mevorach D, Kleinstern G, Paltiel O, Solomon A
Institution:Braun School of Public Health and Community Medicine, Hadassah-Hebrew University of Jerusalem, Israel. Jerusalem, Israel. Israel. Syndrome Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Israel. Jerusalem, Israel. of Jerusalem, Israel. of Jerusalem, Israel. Israel. Jerusalem, Israel.
Journal:J Immunol Res. 2019 Jan 21;2019:9060842. doi: 10.1155/2019/9060842. eCollection 2019.

5:Sjogren's Syndrome: Concerted Triggering of Sicca Conditions.
Authors:Mackiewicz Z, Mazul J, Narkeviciute I, Dumalakiene I, Butrimiene I, Viliene R, Stankeviciene I, Mieliauskaite D
Institution:Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania. Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania. Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania. Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania. Vilnius Gediminas Technical University, Sauletekio al. 11, LT-10223 Vilnius, Lithuania. Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania. Lithuania. Medicine, Santariskiu St. 5, LT-08406 Vilnius, Lithuania.
Journal:J Immunol Res. 2019 Jan 6;2019:2075803. doi: 10.1155/2019/2075803. eCollection 2019.

6:Distorted Taste and Impaired Oral Health in Patients with Sicca Complaints
Authors:Singh PB, Young A, Homayouni A, Hove LH, Petrovski BE, Herlofson BB, Palm O, Rykke M, Jensen JL
Institution:Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, 0317 Oslo, Norway. p.b.singh@odont.uio.no. Oslo, 0317 Oslo, Norway. a.y.vik@odont.uio.no. Oslo, 0317 Oslo, Norway. amin.homayouni@odont.uio.no. Oslo, 0317 Oslo, Norway. l.h.hove@odont.uio.no. University of Oslo, 0317 Oslo, Norway. beata.petrovski@odont.uio.no. Oslo, 0317 Oslo, Norway. b.b.herlofson@odont.uio.no. oypalm@gmail.com. Oslo, 0317 Oslo, Norway. morten.rykke@odont.uio.no. Oslo, 0317 Oslo, Norway. j.c.l.jensen@odont.uio.no.
Journal:Nutrients. 2019 Jan 24;11(2). pii: nu11020264. doi: 10.3390/nu11020264.

7:Sjogren's Syndrome: More Than Just Dry Eye.
Authors:Akpek EK, Bunya VY, Saldanha IJ
Institution:The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD. Synthesis in Health, Brown University School of Public Health, Providence, RI.
Journal:Cornea. 2019 May;38(5):658-661. doi: 10.1097/ICO.0000000000001865.

8:Increased prevalence of Sjogren's syndrome in where soils contain high levels of chromium.
Authors:Lee CP, Hsu PY, Su CC
Institution:Department of Maritime Information and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan. Hospital, Changhua, Taiwan. Hospital, Changhua, Taiwan. Electronic address: 115025@cch.org.tw.
Journal:Sci Total Environ. 2019 Mar 20;657:1121-1126. doi: 10.1016/j.scitotenv.2018.12.122. Epub 2018 Dec 11.

9:Fluocinolone acetonide intravitreal implant as a therapeutic option for severe Sjogren's syndrome-related keratopathy: a case report.
Authors:Wasielica-Poslednik J, Pfeiffer N, Gericke A
Institution:Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany. joanna.wasielica-poslednik@unimedizin-mainz.de.
Journal:J Med Case Rep. 2019 Jan 24;13(1):21. doi: 10.1186/s13256-018-1916-4.

10:Novel autoantibodies in Sjogren's syndrome: A comprehensive review.
Authors:Martin-Nares E, Hernandez-Molina G
Institution:Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga No. 15, Col. Belisario Dominguez Seccion XVI., CP 14080 Mexico City, Mexico.. Electronic address: gabyhm@yahoo.com.
Journal:Autoimmun Rev. 2019 Feb;18(2):192-198. doi: 10.1016/j.autrev.2018.09.003. Epub 2018 Dec 18.

11:Novel Sjogren's autoantibodies found in fibromyalgia patients with sicca and/or xerostomia.
Authors:Applbaum E, Lichtbroun A
Institution:Rutgers- Robert Wood Johnson Medical School, Piscataway, NJ, USA. Electronic address: ea295@rwjms.rutgers.edu. Brunswick, NJ, USA.
Journal:Autoimmun Rev. 2019 Feb;18(2):199-202. doi: 10.1016/j.autrev.2018.09.004. Epub 2018 Dec 18.

12:Lymphomagenesis in Sjogren's syndrome: Predictive biomarkers towards precision medicine.
Authors:Goules AV, Tzioufas AG
Institution:Department of Pathophysiology, School of Medicine, University of Athens, Mikras Asias Str 75, 115 27 Athens, Greece. Asias Str 75, 115 27 Athens, Greece. Electronic address: agtzi@med.uoa.gr.
Journal:Autoimmun Rev. 2019 Feb;18(2):137-143. doi: 10.1016/j.autrev.2018.08.007. Epub 2018 Dec 17.

13:Targeting primary Sjogren's syndrome.
Authors:Odani T, Chiorini JA
Institution:a Adeno-Associated Virus Biology Section, Molecular Physiology and Therapeutics Branch , National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda , MD , USA.
Journal:Mod Rheumatol. 2019 Jan;29(1):70-86. doi: 10.1080/14397595.2018.1546268.

14:Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjogren syndrome.
Authors:Pereira E Silva R, Romao VC, Neves M, Garcia R, Oliveira S, Brites J, Ramos FO, Canhao H, Palma Dos Reis J, Pereira da Silva JA, Lopes T
Institution:1 Urology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Centro Academico de Medicina de Lisboa, Lisbon, Portugal.; 2 Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Centro Academico de Medicina de Lisboa, Lisbon, Portugal.; 3 Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.; 4 Internal Medicine Department, Hospital Fernando Fonseca, Amadora, Portugal.; 5 General practice, USF arsMedica, Loures, Portugal.
Journal:Lupus. 2019 Jan;28(1):27-33. doi: 10.1177/0961203318811605. Epub 2018 Nov 12.

15:Clinical features and potential relevant factors of renal involvement in primary Sjogren's syndrome.
Authors:Luo J, Xu S, Lv Y, Huang X, Zhang H, Zhu X, Wang X
Institution:Rheumatology Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. University, Wenzhou, China. University, Wenzhou, China. University, Wenzhou, China. University, Wenzhou, China. University, Wenzhou, China. University, Wenzhou, China.
Journal:Int J Rheum Dis. 2019 Feb;22(2):182-190. doi: 10.1111/1756-185X.13429. Epub 2018 Nov 8.

16:Arthritis in primary Sjogren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study.
Authors:Mirouse A, Seror R, Vicaut E, Mariette X, Dougados M, Fauchais AL, Deroux A, Dellal A, Costedoat-Chalumeau N, Denis G, Sellam J, Arlet JB, Lavigne C, Urbanski G, Fischer-Dumont D, Diallo A, Fain O, Mekinian A
Institution:Service de medecine interne, Hopital Saint-Antoine, APHP, Paris, France; Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine (CRSA), F-75012 Paris, France. Electronic address: arsene.mekinian@aphp.fr.; Service de rhumatologie, Hopital du Kremlin-Bicetre, APHP, Bicetre, France.; Service de biostatistiques medicales, Hopital Lariboisiere, APHP, France.; Service de rhumatologie B, Hopital Cochin, Paris, France.; Service de medecine interne, CHU de Limoges, Limoges, France.
Journal:Autoimmun Rev. 2019 Jan;18(1):9-14. doi: 10.1016/j.autrev.2018.06.015. Epub 2018 Nov 5.

17:The efficacy and safety of total glucosides of peony in the treatment of primary Sjogren's syndrome: a multi-center, randomized, double-blinded, placebo-controlled clinical trial.
Authors:Liu X, Li X, Li X, Li Z, Zhao D, Liu S, Zhang M, Zhang F, Zhu P, Chen J, Wei W, Lin B, Zhou Y, Chen J, Pang Y, Zhang L, Sun X, Yu Z, Jia Y, Wang J, Sun W, Chiu F, Pang L, Wang G
Institution:Department of Rheumatology, China-Japan Friendship Hospital, No.2, East Yinghua Road, Chaoyang District, Beijing, 100029, China. guochunwang@hotmail.com.; Department of Rheumatology and Immunology, Anhui Provincial Hospital, Hefei, Anhui, China.; Department of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.; Department of Rheumatology and Immunology, Changhai Hospital, Shanghai, China.; Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Journal:Clin Rheumatol. 2019 Mar;38(3):657-664. doi: 10.1007/s10067-018-4315-8. Epub 2018 Oct 2.

18:Is sonoelastography a helpful method of evaluation to diagnose Sjogren's syndrome?
Authors:Pia LJ, Juan BM, Frank P, Angela AA, Jose G, Juan de Dios BS
Institution:Instituto Murciano de Investigacion Biosanitaria (IMIB-Arrixaca-UMU), Hospital Clinico Universitario Virgen de la Arrixaca, Murcia, Spain. Murcia, Murcia, Spain. (Murcia), Spain University Murcia, Murcia, Spain. Spain. Murcia, Murcia, Spain. Spain. (Murcia), Spain University Murcia, Murcia, Spain.
Journal:Int J Rheum Dis. 2019 Feb;22(2):175-181. doi: 10.1111/1756-185X.13373. Epub 2018 Sep 5.

19:Association between primary Sjogren's syndrome, arterial stiffness, and subclinical atherosclerosis: a systematic review and meta-analysis.
Authors:Yong WC, Sanguankeo A, Upala S
Institution:Department of Internal Medicine, Greenfield Family Medicine, Baystate Franklin Medical Center, 48 Sanderson Street, Greenfield, MA, 01301, USA. waichung.yongmd@baystatehealth.org. MD, USA. Hospital, Mahidol University, Bangkok, Thailand. Hospital, Mahidol University, Bangkok, Thailand. University of Chicago, Chicago, IL, USA.
Journal:Clin Rheumatol. 2019 Feb;38(2):447-455. doi: 10.1007/s10067-018-4265-1. Epub 2018 Sep 3.

20:Risk of dementia among patients with Sjogren's syndrome: A nationwide population-based cohort study in Taiwan.
Authors:Chen HH, Perng WT, Chiou JY, Wang YH, Huang JY, Wei JC
Institution:Institute of Medicine, Taichung, Chung Shan Medical University, Taiwan; Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital. Department of Recreation Sport & Health Promotion, National Pingtung University of Science and Technology. Taiwan. Taiwan. Taiwan. of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. Electronic address: jccwei@gmail.com.
Journal:Semin Arthritis Rheum. 2019 Apr;48(5):895-899. doi: 10.1016/j.semarthrit.2018.06.007. Epub 2018 Jun 21.

21:Immunoresponsive Autonomic Neuropathy in Sjogren Syndrome-Case Series and Literature Review.
Authors:Goodman BP
Journal:Am J Ther. 2019 Jan/Feb;26(1):e66-e71. doi: 10.1097/MJT.0000000000000583.

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