Sjogren's Syndrome
September 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Prevalence, risk factors, and prognosis of interstitial lung disease in a large cohort of Chinese primary Sjogren syndrome patients: A case-control study.
Authors:Gao H, Zhang XW, He J, Zhang J, An Y, Sun Y, Jia RL, Li SG, Zhang LJ, Li ZG
Institution:Department of Rheumatology and Immunology, Peking University People's Hospital. China.
Journal:Medicine (Baltimore). 2018 Jun;97(24):e11003. doi: 10.1097/MD.0000000000011003.

2:Outcomes of Thermal Pulsation Treatment for Dry Eye Syndrome in Patients With Sjogren Disease.
Authors:Godin MR, Stinnett SS, Gupta PK
Institution:Department of Ophthalmology, Division of Cornea and Refractive Surgery, Duke University Eye Center Durham, NC.
Journal:Cornea. 2018 Sep;37(9):1155-1158. doi: 10.1097/ICO.0000000000001621.

3:Combined classification system based on ACR/EULAR and ultrasonographic scores for improving the diagnosis of Sjogren's syndrome.
Authors:Takagi Y, Nakamura H, Sumi M, Shimizu T, Hirai Y, Horai Y, Takatani A, Kawakami A, Eida S, Sasaki M, Nakamura T
Institution:Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Nagasaki, Japan.
Journal:PLoS One. 2018 Apr 3;13(4):e0195113. doi: 10.1371/journal.pone.0195113. eCollection 2018.

4:Orofacial Manifestations and Temporomandibular Disorders of Sjogren Syndrome: An Observational Study.
Authors:Crincoli V, Di Comite M, Guerrieri M, Rotolo RP, Limongelli L, Tempesta A, Iannone F, Rinaldi A, Lapadula G, Favia G
Institution:Interdisciplinary Department of Medicine, University of Bari, Italy. University of Bari, Italy.
Journal:Int J Med Sci. 2018 Mar 8;15(5):475-483. doi: 10.7150/ijms.23044. eCollection 2018.

5:Utility of Novel Autoantibodies in the Diagnosis of Sjogren's Syndrome Among Patients With Dry Eye.
Authors:Karakus S, Baer AN, Agrawal D, Gurakar M, Massof RW, Akpek EK
Institution:Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD. Hopkins University, Baltimore, MD. Hopkins University, Baltimore, MD. Hopkins University, Baltimore, MD. Hopkins University, Baltimore, MD.
Journal:Cornea. 2018 Apr;37(4):405-411. doi: 10.1097/ICO.0000000000001471.

6:Comparative analysis of the 2016 ACR-EULAR and the 2002 AECG classification criteria for Sjogren's syndrome: Findings from the NIH cohort.
Authors:Billings M, Amin Hadavand M, Alevizos I
Institution:National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Health, Bethesda, MD, USA.
Journal:Oral Dis. 2018 Mar;24(1-2):184-190. doi: 10.1111/odi.12772.

7:Expression of interleukin-17 in primary Sjogren's syndrome and the correlation with disease severity: A systematic review and meta-analysis.
Authors:Zhang LW, Zhou PR, Wei P, Cong X, Wu LL, Hua H
Institution:Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
Journal:Scand J Immunol. 2018 Apr;87(4):e12649. doi: 10.1111/sji.12649.

8:Validation of the ACR-EULAR criteria for primary Sjogren's syndrome in a Dutch prospective diagnostic cohort.
Authors:van Nimwegen JF, van Ginkel MS, Arends S, Haacke EA, van der Vegt B, Sillevis Smitt-Kamminga N, Spijkervet FKL, Kroese FGM, Stel AJ, Brouwer E, Vissink A, Bootsma H
Institution:Departments of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Ophtalmology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Journal:Rheumatology (Oxford). 2018 May 1;57(5):818-825. doi: 10.1093/rheumatology/kex495.

9:Salivary gland ultrasonography findings are associated with clinical, histological, and serologic features of Sjogren's syndrome.
Authors:Kim JW, Lee H, Park SH, Kim SK, Choe JY, Kim JK
Institution:a Division of Rheumatology, Department of Internal Medicine , Catholic University of Daegu School of Medicine , Daegu , Korea.; b Department of Otolaryngology Head and Neck Surgery , Catholic University of Daegu School of Medicine , Daegu , Korea.
Journal:Scand J Rheumatol. 2018 Jul;47(4):303-310. doi: 10.1080/03009742.2017.1374451. Epub 2018 Feb 7.

10:Clinical practice guideline for Sjogren's syndrome 2017.
Authors:Sumida T, Azuma N, Moriyama M, Takahashi H, Asashima H, Honda F, Abe S, Ono Y, Hirota T, Hirata S, Tanaka Y, Shimizu T, Nakamura H, Kawakami A, Sano H, Ogawa Y, Tsubota K, Ryo K, Saito I, Tanaka A, Nakamura S, Takamura E, Tanaka M, Suzuki K, Takeuchi T, Yamakawa N, Mimori T, Ohta A, Nishiyama S, Yoshihara T, Suzuki Y, Kawano M, Tomiita M, Tsuboi H
Institution:a Department of Internal Medicine , University of Tsukuba , Ibaraki , Japan.; b Clinical Practice Guideline Committee for Sjogren's Syndrome, The Research Team for Autoimmune Diseases, The Research Program for Intractable Disease of the Ministry of Health, Labor and Welfare (MHLW) , Tokyo , Japan.; c Division of Rheumatology, Department of Internal Medicine , Hyogo College of Medicine , Hyogo , Japan.; d Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences , Kyushu University , Fukuoka , Japan.; e The First Department of Internal Medicine , School of Medicine, University of Occupational and Environmental Health, Japan , Fukuoka , Japan.
Journal:Mod Rheumatol. 2018 May;28(3):383-408. doi: 10.1080/14397595.2018.1438093. Epub 2018 Mar 13.

11:Early hearing loss detection in rheumatoid arthritis and primary Sjogren syndrome using extended high frequency audiometry.
Authors:Galarza-Delgado DA, Villegas Gonzalez MJ, Riega Torres J, Soto-Galindo GA, Mendoza Flores L, Trevino Gonzalez JL
Institution:Department of Rheumatology, University of Nuevo Leon, Medicine School and University Hospital, Mexico, San Nicolas de los Garza, Mexico.; Department of Otolaryngology-Head and Neck Surgery, University of Nuevo Leon, Medicine School and University Hospital, Mexico, Av. Madero y Gonzalitos Colonia Mitras Centro, CP 64460, Monterrey, NL, Mexico.
Journal:Clin Rheumatol. 2018 Feb;37(2):367-373. doi: 10.1007/s10067-017-3959-0. Epub 2017 Dec 22.

12:Prevalence and Predictors of Sjogren's Syndrome in Patients with Burning Mouth Symptoms.
Authors:Lee YC, Song R, Yang YJ, Eun YG
Journal:J Oral Facial Pain Headache. Winter 2018;32(1):91-96. doi: 10.11607/ofph.1891. Epub 2017 Dec 15.

13:Population-based study suggests an increased risk of Alzheimer'sdisease in Sjogren's syndrome.
Authors:Liliang PC, Liang CL, Lu K, Yang SN, Hsieh MT, Tai YC, Wang KW
Institution:Department of Neurosurgery, E-Da Cancer Hospital, I-Shou University, No.1, Yida Road, Jiaosu Village, Yanchao District, Kaohsiung, 82445, Taiwan. Taiwan. Road, Jiaosu Village, Yanchao District, Kaohsiung, 82445, Taiwan.
Journal:Clin Rheumatol. 2018 Apr;37(4):935-941. doi: 10.1007/s10067-017-3940-y. Epub 2017 Dec 14.

14:Gastrointestinal and Hepatic Disease in Sjogren Syndrome.
Authors:Popov Y, Salomon-Escoto K
Institution:Department of Medicine, University of Massachusetts Medical School, 119 Belmont Street, Worcester, MA 01605, USA. Electronic address: Street, Worcester, MA 01605, USA.
Journal:Rheum Dis Clin North Am. 2018 Feb;44(1):143-151. doi: 10.1016/j.rdc.2017.09.010.

15:Low-level laser therapy for xerostomia in primary Sjogren's syndrome: a randomized trial.
Authors:Fidelix T, Czapkowski A, Azjen S, Andriolo A, Neto PH, Trevisani V
Institution:Department of Evidence-Based Health, Universidade Federal de Sao Paulo (UNIFESP), Rua Barao do Triunfo, 156/232, Sao Paulo, SP, 04602-000, Brazil.; Department of Radiology, UNIFESP, Sao Paulo, SP, Brazil.; Department of Laboratory Medicine, UNIFESP, Sao Paulo, SP, Brazil.
Journal:Clin Rheumatol. 2018 Mar;37(3):729-736. doi: 10.1007/s10067-017-3898-9. Epub 2017 Nov 9.

16:Renal involvement in primary Sjogren's syndrome: A retrospective study of 103 biopsy-proven cases from a single center in China.
Authors:Yang HX, Wang J, Wen YB, Fei YY, Jiang MD, Zhou MY, Zhang W, Li H, Li XM, Zhang FC, Li XW, Zhang X, Chen LM
Institution:Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College and The Ministry of Education Key Laboratory, Beijing, China.; Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal:Int J Rheum Dis. 2018 Jan;21(1):223-229. doi: 10.1111/1756-185X.13182. Epub 2017 Sep 21.

17:Systematic review and meta-analysis of the epidemiology of polyautoimmunity in Sjogren's syndrome (secondary Sjogren's syndrome) focusing on autoimmune rheumatic diseases.
Authors:Alani H, Henty JR, Thompson NL, Jury E, Ciurtin C
Institution:a Department of Rheumatology, Kettering General Hospital , Kettering , UK.
Journal:Scand J Rheumatol. 2018 Mar;47(2):141-154. doi: 10.1080/03009742.2017.1324909. Epub 2017 Sep 20.

18:Presence of enthesopathy in patients with primary Sjogren's syndrome: ultrasonographic study of a local cohort.
Authors:Sag S, Sag MS, Tekeoglu I, Kamanli A, Nas K
Institution:Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Medical Faculty, Sakarya, Turkey.
Journal:J Med Ultrason (2001). 2018 Jan;45(1):121-127. doi: 10.1007/s10396-017-0802-9. Epub 2017 Jun 23.

19:Depression in primary Sjogren's syndrome: a systematic review and meta-analysis.
Authors:Cui Y, Li L, Yin R, Zhao Q, Chen S, Zhang Q, Shen B
Institution:a Department of Nursing , The Second Affiliated Hospital of Nantong University , Nantong , China. Nantong , China.
Journal:Psychol Health Med. 2018 Feb;23(2):198-209. doi: 10.1080/13548506.2017.1339895. Epub 2017 Jun 16.

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