August 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Thermography Improves Clinical Assessment in Patients with Systemic Sclerosis Treated with Ozone Therapy.
Authors:Nowicka D
Institution:Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Journal:Biomed Res Int. 2017;2017:5842723. doi: 10.1155/2017/5842723. Epub 2017 Mar 2.

2:Intravenous immunoglobulins in systemic sclerosis: Data from a French nationwide cohort of 46 patients and review of the literature.
Authors:Sanges S, Riviere S, Mekinian A, Martin T, Le Quellec A, Chatelus E, Lescoat A, Jego P, Cazalets C, Quemeneur T, Le Gouellec N, Senet P, Frances C, Deroux A, Imbert B, Fain O, Boukari L, Sene T, Deligny C, Mathian A, Agard C, Pugnet G, Speca S, Dubucquoi S, Hatron PY, Hachulla E, Launay D
Institution:Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France; INSERM, U995, F-59000 Lille, France; CHU Lille, Departement de Medecine Interne et Immunologie Clinique, F-59000 Lille, France; Centre National de Reference Maladies Systemiques et Auto-immunes Rares (Sclerodermie Systemique), F-59000 Lille, France; Health Care Provider of the European Reference Network on Rare Connective Tissue and Musculoskeletal Diseases Network (ReCONNET). Electronic address:; AP-HP, Hopital Saint Antoine, Service de Medecine Interne, Paris, France; UPMC Universite Paris 06, Faculte de Medecine Pierre et Marie Curie, Paris, France.; Service d'Immunologie Clinique, Hopitaux universitaires de Strasbourg, UPR CNRS 3572, Strasbourg, France.; Service de Medecine Interne et Maladies Multi-Organiques de l'Adulte, Hopital Saint-Eloi, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier, France.; Hopitaux Universitaires de Strasbourg, CHU Hautepierre, Service de Rhumatologie, Centre de Reference des Maladies Auto-Immunes Systemiques Rares, Universite de Strasbourg, Federation de Medecine Translationnelle de Strasbourg, INSERM UMR 1109, Strasbourg, France.
Journal:Autoimmun Rev. 2017 Apr;16(4):377-384. doi: 10.1016/j.autrev.2017.02.008. Epub 2017 Feb 13.

3:Consensus best practice pathway of the UK Systemic Sclerosis Study group: management of cardiac disease in systemic sclerosis.
Authors:Bissell LA, Anderson M, Burgess M, Chakravarty K, Coghlan G, Dumitru RB, Graham L, Ong V, Pauling JD, Plein S, Schlosshan D, Woolfson P, Buch MH
Institution:Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds. Trust, Leeds. London. Leeds. Trust, Leeds. Leeds. London. Leeds. Leeds. UK. Leeds. Trust, Leeds.
Journal:Rheumatology (Oxford). 2017 Jun 1;56(6):912-921. doi: 10.1093/rheumatology/kew488.

4:Kidney transplantation in patients with systemic sclerosis: a nationwide multicentre study.
Authors:Bertrand D, Dehay J, Ott J, Sberro R, Brunelle C, Kamar N, Colosio C, Chatelet V, Albano L, Girerd S, Audard V, Barbet C, Dantal J, Ducloux D, Durrbach A, Garrigue V, Hazzan M, Heng AE, Mariat C, Merville P, Rerolle JP, Moulin B, Guerrot D
Institution:Nephrology Dialysis Transplantation, Centre Hospitalier Universitaire de Rouen, Rouen, Haute-Normandie, France. Rouen, Haute-Normandie, France. Strasbourg, Strasbourg, Alsace, France. France. Garonne, France. France. France. Clermont-Ferrand, France. Strasbourg, Strasbourg, Alsace, France. Rouen, Haute-Normandie, France.
Journal:Transpl Int. 2017 Mar;30(3):256-265. doi: 10.1111/tri.12923.

5:Occupational and environmental scleroderma. Systematic review and meta-analysis.
Authors:Rubio-Rivas M, Moreno R, Corbella X
Institution:Autoimmune Diseases Unit. Department of Internal Medicine, Bellvitge University Hospital-IDIBELL. L'Hospitalet de Llobregat, Feixa Llarga s/n, Hospitalet de Llobregat, Barcelona, Spain.; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.
Journal:Clin Rheumatol. 2017 Mar;36(3):569-582. doi: 10.1007/s10067-016-3533-1. Epub 2017 Jan 14.

6:Cardiopulmonary exercise testing for detecting pulmonary arterial hypertension in systemic sclerosis.
Authors:Dumitrescu D, Nagel C, Kovacs G, Bollmann T, Halank M, Winkler J, Hellmich M, Grunig E, Olschewski H, Ewert R, Rosenkranz S
Institution:Herzzentrum der Universitat zu Koln, Klinik III fur Innere Medizin, Cologne, Germany. Institute for Lung Vascular Research, and Medical University of Graz, Graz, Austria. and Infectious Diseases, University of Greifswald, Greifswald, Germany. Technical University of Dresden, Dresden, Germany. Institute for Lung Vascular Research, and Medical University of Graz, Graz, Austria. and Infectious Diseases, University of Greifswald, Greifswald, Germany. Germany.
Journal:Heart. 2017 May;103(10):774-782. doi: 10.1136/heartjnl-2016-309981. Epub 2017 Jan 6.

7:Clinical correlates of faecal incontinence in systemic sclerosis: identifying therapeutic avenues.
Authors:Richard N, Hudson M, Gyger G, Baron M, Sutton E, Khalidi N, Pope JE, Carrier N, Larche M, Albert A, Fortin PR, Thorne C, Masetto A
Institution:Division of Rheumatology, Jewish General Hospital, McGill University, Montreal, Quebec. Quebec. Quebec. Quebec. University, Halifax, Nova Scotia. London, Ontario. Universite de Sherbrooke, Sherbrooke. Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
Journal:Rheumatology (Oxford). 2017 Apr 1;56(4):581-588. doi: 10.1093/rheumatology/kew441.

8:Improved Cough and Cough-Specific Quality of Life in Patients Treated for Scleroderma-Related Interstitial Lung Disease: Results of Scleroderma Lung Study II.
Authors:Tashkin DP, Volkmann ER, Tseng CH, Roth MD, Khanna D, Furst DE, Clements PJ, Theodore A, Kafaja S, Kim GH, Goldin J, Ariolla E, Elashoff RM
Institution:Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: Angeles, CA. Angeles, CA. Los Angeles, CA. Angeles, CA.
Journal:Chest. 2017 Apr;151(4):813-820. doi: 10.1016/j.chest.2016.11.052. Epub 2016 Dec 22.

9:Nail involvement in systemic sclerosis.
Authors:Marie I, Gremain V, Nassermadji K, Richard L, Joly P, Menard JF, Levesque H
Institution:Department of Internal Medicine, Rouen University Hospital, Rouen, France; Institut National de la Sante et de la Recherche Medicale U 905, University of Rouen Institut Federatif Multidisciplinaire sur les Peptides, Institute for Biochemical Research, Rouen, France. Electronic address:; Department of Dermatology, Rouen University Hospital, Rouen, France; Institut National de la Sante et de la Recherche Medicale U 905, University of Rouen Institut Federatif Multidisciplinaire sur les Peptides, Institute for Biochemical Research, Rouen, France.; Department of Biostatistics, Rouen University Hospital, Rouen, France.
Journal:J Am Acad Dermatol. 2017 Jun;76(6):1115-1123. doi: 10.1016/j.jaad.2016.11.024. Epub 2016 Dec 20.

10:Genomic and genetic studies of systemic sclerosis: A systematic review.
Authors:Chairta P, Nicolaou P, Christodoulou K
Institution:Neurogenetics Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus; Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus. Electronic address:
Journal:Hum Immunol. 2017 Feb;78(2):153-165. doi: 10.1016/j.humimm.2016.10.017. Epub 2016 Oct 29.

11:Primary myocardial disease in scleroderma-a comprehensive review of the literature to inform the UK Systemic Sclerosis Study Group cardiac working group.
Authors:Bissell LA, Md Yusof MY, Buch MH
Institution:Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital.; NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Journal:Rheumatology (Oxford). 2017 Jun 1;56(6):882-895. doi: 10.1093/rheumatology/kew364.

12:Recent advances in the management of juvenile systemic sclerosis.
Authors:Zulian F, Balzarin M, Birolo C
Institution:a Pediatric Rheumatology Unit, Department for Woman and Child Health , University of Padua , Padua , Italy. of Padua , Padua , Italy. of Padua , Padua , Italy.
Journal:Expert Rev Clin Immunol. 2017 Apr;13(4):361-369. doi: 10.1080/1744666X.2017.1243467. Epub 2016 Oct 11.

13:Riociguat for the treatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2.
Authors:Humbert M, Coghlan JG, Ghofrani HA, Grimminger F, He JG, Riemekasten G, Vizza CD, Boeckenhoff A, Meier C, de Oliveira Pena J, Denton CP
Institution:Universite Paris-Sud, Faculte de Medecine, Universite Paris-Saclay, Le Kremlin Bicetre, France. Lung Research (DZL)), Giessen, Germany. Lung Research (DZL)), Giessen, Germany. China.
Journal:Ann Rheum Dis. 2017 Feb;76(2):422-426. doi: 10.1136/annrheumdis-2015-209087. Epub 2016 Jul 25.

14:Safety and tolerability of bosentan for digital ulcers in Japanese patients with systemic sclerosis: Prospective, multicenter, open-label study.
Authors:Hamaguchi Y, Sumida T, Kawaguchi Y, Ihn H, Tanaka S, Asano Y, Motegi SI, Kuwana M, Endo H, Takehara K
Institution:Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. Tsukuba, Japan. University, Kumamoto, Japan. Hospital, Sagamihara, Japan. Tokyo, Japan. Maebashi, Japan. of Medicine, Tokyo, Japan. Japan. Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Journal:J Dermatol. 2017 Jan;44(1):13-17. doi: 10.1111/1346-8138.13497. Epub 2016 Jul 4.

15:Effect of treatment with iloprost with or without bosentan on nailfold videocapillaroscopic alterations in patients with systemic sclerosis.
Authors:Cestelli V, Manfredi A, Sebastiani M, Praino E, Cannarile F, Giuggioli D, Ferri C
Institution:a Rheumatology Unit , University of Modena and Reggio Emilia , Italy.
Journal:Mod Rheumatol. 2017 Jan;27(1):110-114. doi: 10.1080/14397595.2016.1192761. Epub 2016 Jun 16.

16:Digital ulcers in systemic sclerosis.
Authors:Hughes M, Herrick AL
Institution:Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester. Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Journal:Rheumatology (Oxford). 2017 Jan;56(1):14-25. doi: 10.1093/rheumatology/kew047. Epub 2016 Apr 19.

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