Lymphedema
March 2022 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Lymphedema abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Lymphedema. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Lymphedema. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Lymphedema every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:The 24-hour interval compression plan: part 2-lifestyle and therapeutic regimens to manage chronic oedema case series.
Authors:Bock KJ, Ehmann JS, Muldoon J
Institution:Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, US. Independent Clinical Researcher, Maidenhead, England, UK.
Journal:J Wound Care. 2022 Mar 2;31(3):218-223. doi: 10.12968/jowc.2022.31.3.218.

2:Lymphoedema and cancer: an overview.
Authors:Bott T
Institution:Clinical Trials Database Nurse, Cancer Research UK.
Journal:Br J Nurs. 2022 Feb 10;31(3):120-122. doi: 10.12968/bjon.2022.31.3.120.

3:Supermicrosurgical treatment for lymphedema: a systematic review and network meta-analysis protocol.
Authors:Will PA, Wan Z, Seide SE, Berner JE, Kneser U, Gazyakan E, Hirche C
Institution:Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Centre, BG Trauma Center Ludwigshafen, Ludwig Guttmann Str. 13, 67071, Ludwigshafen am Rhein, Germany. p.will-marks@bgu-ludwigshafen.de. Department of Plastic, Hand, and Reconstructive Microsurgery, BG-Trauma Hospital Frankfurt am Main, Frankfurt am Main, Germany.
Journal:Syst Rev. 2022 Feb 1;11(1):18. doi: 10.1186/s13643-022-01885-9.

4:Self-management Strategies for Risk Reduction of Subclinical and Mild Stage of Breast Cancer-Related Lymphedema: A Longitudinal, Quasi-experimental Study.
Authors:Liu F, Li F, Fu MR, Zhao Q, Wang Y, Pang D, Yang P, Jin S, Lu Q
Institution:Author Affiliations: Department of General Surgery, Peking University First Hospital (Dr Liu and Ms Wang); and Department of Medical & Surgical Nursing, Peking University School of Nursing (Drs Li, Pang, Yang, Jin, and Lu), Beijing, China; William F. Connell School of Nursing, Boston College, Massachusetts (Dr Fu); Department of Breast Surgery, Peking University People's Hospital, Beijing, China (Ms Zhao).
Journal:Cancer Nurs. 2021 Nov-Dec 01;44(6):E493-E502. doi: 10.1097/NCC.0000000000000919.

5:Effect of exercise mode on physical function and quality of life in breast cancer-related lymphedema: a randomized trial.
Authors:Basha MA, Aboelnour NH, Alsharidah AS, Kamel FH
Institution:Department of Physical Therapy, College of Medical Rehabilitation, Qassim University, Buraidah, Qassim, Saudi Arabia. Bashamaged@gmail.com.
Journal:Support Care Cancer. 2022 Mar;30(3):2101-2110. doi: 10.1007/s00520-021-06559-1. Epub 2021 Oct 20.

6:Nighttime compression supports improved self-management of breast cancer-related lymphedema: A multicenter randomized controlled trial.
Authors:McNeely ML, Dolgoy ND, Rafn BS, Ghosh S, Ospina PA, Al Onazi MM, Radke L, Shular M, Kuusk U, Webster M, Campbell KL, Mackey JR
Institution:Department of Physical Therapy, University of Alberta, Edmonton, Alberta, Canada. Cross Cancer Institute, Alberta Health Services, Edmonton, Alberta, Canada.
Journal:Cancer. 2022 Feb 1;128(3):587-596. doi: 10.1002/cncr.33943. Epub 2021 Oct 6.

7:Risk factors for lymphedema after breast surgery: A prospective cohort study in the era of sentinel lymph node biopsy.
Authors:Salinas-Huertas S, Luzardo-González A, Vázquez-Gallego S, Pernas S, Falo C, Pla MJ, Gil-Gil M, Beranuy-Rodriguez M, Pérez-Montero H, Gomila-Sancho M, Manent-Molina N, Arencibia-Domínguez A, Gonzalez-Pineda B, Tormo-Collado F, Ortí-Asencio M, Terra J, Martinez-Perez E, Mestre-Jane A, Campos-Varela I, Jaraba-Armas M, Benítez-Segura A, Campos-Delgado M, Fernández-Montolí ME, Valverde-Alcántara Y, Rodríguez A, Campos G, Guma A, Ponce-Sebastià J, Planas-Balagué R, Catasús-Clavé M, García-Tejedor A
Institution:Department of Rehabilitation, Hospital Universitari Bellvitge, Idibell, Universitat de Barcelona, Barcelona, Spain. Department of Gynecology, Multidisciplinary Breast Cancer Unit, Hospital Universitari Bellvitge, Idibell, Universitat de Barcelona, Barcelona, Spain.
Journal:Breast Dis. 2022;41(1):97-108. doi: 10.3233/BD-210043.

8:Physical therapies in the decongestive treatment of lymphedema: A randomized, non-inferiority controlled study.
Authors:Forner-Cordero I, Muñoz-Langa J, DeMiguel-Jimeno JM, Rel-Monzó P
Institution:Lymphedema Unit, Rehabilitation Department, Hospital Universitari i Politecnic La Fe, Valencia, Spain. Phyisiotherapy Service, Hospital Universitari i Politecnic La Fe, Valencia, Spain.
Journal:Clin Rehabil. 2021 Dec;35(12):1743-1756. doi: 10.1177/02692155211032651. Epub 2021 Sep 13.

9:Diagnostic Criteria for Breast Cancer-Related Lymphedema of the Upper Extremity: The Need for Universal Agreement.
Authors:Kassamani YW, Brunelle CL, Gillespie TC, Bernstein MC, Bucci LK, Nassif T, Taghian AG
Institution:Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. ATAGHIAN@mgh.harvard.edu.
Journal:Ann Surg Oncol. 2022 Feb;29(2):989-1002. doi: 10.1245/s10434-021-10645-3. Epub 2021 Sep 9.

10:Treatment Outcomes of Manual Lymphatic Drainage in Pediatric Lymphedema.
Authors:Ali K, Dibbs RP, Dougherty C, Iacobas I, Maricevich RS
Institution:Division of Plastic Surgery, Baylor College of Medicine, Houston, TX.; Division of Hematology/Oncology, Texas Children's Hospital, Houston, TX.. Electronic address: renata.maricevich@bcm.edu.
Journal:Ann Vasc Surg. 2022 Jan;78:263-271. doi: 10.1016/j.avsg.2021.06.021. Epub 2021 Sep 1.

11:Efficacy of Microsurgical Treatment of Primary Lymphedema: A Systematic Review.
Authors:Fallahian F, Tadisina KK, Xu KY
Institution:From the Department of Surgery. Division of Plastic Surgery, University of Miami Miller School of Medicine, Miami, FL.
Journal:Ann Plast Surg. 2022 Feb 1;88(2):195-199. doi: 10.1097/SAP.0000000000002862.

12:Breast cancer-related lymphoedema: Risk factors and prediction model.
Authors:Martínez-Jaimez P, Armora Verdú M, Forero CG, Álvarez Salazar S, Fuster Linares P, Monforte-Royo C, Masia J
Institution:Breast Reconstruction and Lymphoedema Surgery Unit, Clinica Planas, Barcelona, Spain.
Journal:J Adv Nurs. 2022 Mar;78(3):765-775. doi: 10.1111/jan.15005. Epub 2021 Aug 7.

13:Breast cancer related upper limb lymphedema: approach and surgical management.
Authors:Bianchi A, Salgarello M, Hayashi A, Visconti G
Institution:Unit of Plastic Surgery, Department for Women's and Children's Health and Public Health, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy. Health, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy. Health, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy - giuseppe.visconti@policlinicogemelli.it.
Journal:Minerva Surg. 2021 Dec;76(6):575-579. doi: 10.23736/S2724-5691.21.09013-4. Epub 2021 Aug 2.

14:Weight loss does not decrease risk of breast cancer-related arm lymphedema.
Authors:Roberts SA, Gillespie TC, Shui AM, Brunelle CL, Daniell KM, Locascio JJ, Naoum GE, Taghian AG
Institution:Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. School, Boston, Massachusetts. Boston, Massachusetts. Boston, Massachusetts. School, Boston, Massachusetts. Boston, Massachusetts. School, Boston, Massachusetts. School, Boston, Massachusetts.
Journal:Cancer. 2021 Nov 1;127(21):3939-3945. doi: 10.1002/cncr.33819. Epub 2021 Jul 27.

15:Breast cancer-related lymphedema patient and healthcare professional experiences in lymphedema self-management: a qualitative study.
Authors:Zhao H, Wu Y, Zhou C, Li W, Li X, Chen L
Institution:Nanfang Hospital, Southern Medical University, NO.1838 Guangzhou Avenue North, Guangzhou, Guangdong, 510515, People's Republic of China. Guangzhou, Guangdong, 510515, People's Republic of China. Guangzhou, Guangdong, 510515, People's Republic of China. 495837129@qq.com. Guangzhou, Guangdong, 510515, People's Republic of China. Guangzhou, Guangdong, 510515, People's Republic of China. Guangzhou, Guangdong, 510515, People's Republic of China.
Journal:Support Care Cancer. 2021 Dec;29(12):8027-8044. doi: 10.1007/s00520-021-06390-8. Epub 2021 Jul 5.

16:Loco-regional therapy and the risk of breast cancer-related lymphedema: a systematic review and meta-analysis.
Authors:Lin Y, Xu Y, Wang C, Song Y, Huang X, Zhang X, Cao X, Sun Q
Institution:Department of Breast Disease, Peking Union Medical College Hospital, Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. pumclinyan@163.com.
Journal:Breast Cancer. 2021 Nov;28(6):1261-1272. doi: 10.1007/s12282-021-01263-8. Epub 2021 Jun 9.

17:Cellulitis risk factors for patients with primary or secondary lymphedema.
Authors:Vignes S, Poizeau F, Dupuy A
Institution:Department of Lymphology, Referral Center for Rare Vascular Diseases, Cognacq-Jay Hospital, Paris, France. Electronic address: stephane.vignes@cognacq-jay.fr. Department of Dermatology, Centre Hospitalier Universitaire de Rennes, Rennes, France; EA 7449 REPERES (Pharmacoepidemiology and Health Services Research), Rennes 1 University, Rennes, France.
Journal:J Vasc Surg Venous Lymphat Disord. 2022 Jan;10(1):179-185.e1. doi: 10.1016/j.jvsv.2021.04.009. Epub 2021 May 3.

18:It was just mind blowing to be honest: a qualitative phenomenological study exploring cancer survivor's experiences of indocyanine green lymphography used to inform lymphedema therapy management.
Authors:Pigott A, Doig E, McCann A, Trevethan M
Institution:Princess Alexandra Hospital, Brisbane, QLD, Australia. amanda.pigott@health.qld.gov.au. Health Service, Brisbane, Australia.
Journal:Support Care Cancer. 2021 Nov;29(11):6389-6397. doi: 10.1007/s00520-021-06229-2. Epub 2021 Apr 22.

19:Breast cancer treatment-related arm lymphoedema and morbidity: A 6-year experience in an Australian tertiary breast centre.
Authors:Huang YY, Toh PY, Hunt C, Lin JTW, Kamyab R, Ponniah AK
Institution:Department of Breast Surgery, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Journal:Asia Pac J Clin Oncol. 2022 Feb;18(1):109-117. doi: 10.1111/ajco.13523. Epub 2021 Feb 25.

20:Predictors of Quality of Life in Patients with Breast Cancer-Related Lymphedema: Effect of Age, Lymphedema Severity, and Anxiety.
Authors:Zhang L, Zhang H, Zhong Q, Luo Q, Gong N, Zhang Y, Qin H, Zhang H
Institution:State Key Laboratory of Oncology in South China, Guangzhou, China.
Journal:Lymphat Res Biol. 2021 Dec;19(6):573-579. doi: 10.1089/lrb.2020.0073. Epub 2021 Feb 8.

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"Lymphedema is a rare condition... and my specific type of lymphedema (congenital lymphedema) is even more rare. Your Guidebook covered the recommendations for treatment with a thoroughness I've seen nowhere else. Thank you for taking the time to offer current information about Lymphedema that empowers me to take control of my health care."
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