Glioblastoma
January 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Glioblastoma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Glioblastoma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Glioblastoma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Glioblastoma every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Accelerated hyperfractionation plus temozolomide in glioblastoma.
Authors:Kaul D, Florange J, Badakhshi H, Grun A, Ghadjar P, Exner S, Budach V
Institution:Klinik fur Radioonkologie und Strahlentherapie, Charite Universitatsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. david.kaul@charite.de.
Journal:Radiat Oncol. 2016 May 21;11:70. doi: 10.1186/s13014-016-0645-3.

2:Clipping the Wings of Glioblastoma: Modulation of WNT as a Novel Therapeutic Strategy.
Authors:Suwala AK, Hanaford A, Kahlert UD, Maciaczyk J
Institution:From the Department of Neurosurgery, University Medical Center Dusseldorf, Dusseldorf, Germany (AKS, UDK, JM); and Division of Neuropathology, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland (AH). Jaroslaw.Maciaczyk@med.uni-duesseldorf.de.
Journal:J Neuropathol Exp Neurol. 2016 May;75(5):388-96. doi: 10.1093/jnen/nlw013. Epub 2016 Mar 15.

3:The challenges associated with molecular targeted therapies for glioblastoma.
Authors:Jue TR, McDonald KL
Institution:Cure Brain Cancer Foundation Biomarkers and Translational Research Group, University of NSW, Kensington, Australia. University of NSW, Kensington, Australia. k.mcdonald@unsw.edu.au.
Journal:J Neurooncol. 2016 May;127(3):427-34. doi: 10.1007/s11060-016-2080-6. Epub 2016 Feb 22.

4:Bevacizumab and temozolomide versus temozolomide alone as neoadjuvant treatment in unresected glioblastoma: the GENOM 009 randomized phase II trial.
Authors:Balana C, De Las Penas R, Sepulveda JM, Gil-Gil MJ, Luque R, Gallego O, Carrato C, Sanz C, Reynes G, Herrero A, Ramirez JL, Perez-Segura P, Berrocal A, Vieitez JM, Garcia A, Vazquez-Estevez S, Peralta S, Fernandez I, Henriquez I, Martinez-Garcia M, De la Cruz JJ, Capellades J, Giner P, Villa S
Institution:Medical Oncology Service, Institut Catala d'Oncologia, Hospital Universitari Germans Trias i Pujol, Carretera Canyet, s/n, 08916, Badalona, Spain. cbalana@iconcologia.net. Llobregat, Barcelona, Spain. Spain. Universitari Germans Trias i Pujol, Badalona, Spain. Spain. Spain. Spain. Autonomous University of Madrid, Madrid, Spain. Spain. Germans Trias i Pujol, Badalona, Spain.
Journal:J Neurooncol. 2016 May;127(3):569-79. doi: 10.1007/s11060-016-2065-5. Epub 2016 Feb 3.

5:Advances in HSP27 and HSP90-targeting strategies for glioblastoma.
Authors:van Ommeren R, Staudt MD, Xu H, Hebb MO
Institution:Department of Clinical Neurological Sciences, Western University, 339 Windermere Road, Suite C7-134, London, ON, N6A 5A5, Canada. mhebb@uwo.ca.
Journal:J Neurooncol. 2016 Apr;127(2):209-19. doi: 10.1007/s11060-016-2070-8. Epub 2016 Feb 2.

6:Therapeutic options in recurrent glioblastoma--An update.
Authors:Seystahl K, Wick W, Weller M
Institution:Department of Neurology, University Hospital Zurich, Zurich, Switzerland. Electronic address: katharina.seystahl@usz.ch. Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Journal:Crit Rev Oncol Hematol. 2016 Mar;99:389-408. doi: 10.1016/j.critrevonc.2016.01.018. Epub 2016 Jan 21.

7:Second surgery for recurrent glioblastoma: A concise overview of the current literature.
Authors:Montemurro N, Perrini P, Blanco MO, Vannozzi R
Institution:Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana (AOUP), University of Pisa, Pisa, Italy. Electronic address: montemurronic@hotmail.com.; Hospital Universitario Virgen Del Rocio, Seville, Spain.
Journal:Clin Neurol Neurosurg. 2016 Mar;142:60-4. doi: 10.1016/j.clineuro.2016.01.010. Epub 2016 Jan 14.

8:Intraventricular Glioblastomas.
Authors:Ben Nsir A, Gdoura Y, Thai QA, Zhani Kassar A, Hattab N, Jemel H
Institution:Department of Neurosurgery, Fattouma Bourguiba University Hospital-University of Medicine of Monastir, Monastir, Tunisia. Electronic address: atefbn@hotmail.fr. of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia. University School of Medicine, Baltimore, Maryland, USA. Tunis, University of Tunis El Manar, Tunis, Tunisia. Medicine of Monastir, Monastir, Tunisia. of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Journal:World Neurosurg. 2016 Apr;88:126-31. doi: 10.1016/j.wneu.2015.12.079. Epub 2016 Jan 8.

9:Spinal cord glioblastoma: 25years of experience from a single institution.
Authors:Yanamadala V, Koffie RM, Shankar GM, Kumar JI, Buchlak QD, Puthenpura V, Frosch MP, Gudewicz TM, Borges LF, Shin JH
Institution:Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, WACC 021, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA. Electronic address: vyanamadala@mgh.harvard.edu.; Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, WACC 021, Boston, MA 02115, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Journal:J Clin Neurosci. 2016 May;27:138-41. doi: 10.1016/j.jocn.2015.11.011. Epub 2016 Jan 2.

10:The optimal regimen of bevacizumab for recurrent glioblastoma: does dose matter?
Authors:Blumenthal DT, Mendel L, Bokstein F
Institution:Neuro-Oncology Service, Division of Oncology, Tel-Aviv Sourasky Medical Center, 6 Weizmann St., 64239, Tel-Aviv, Israel. deborahblumenthal@gmail.com. Weizmann St., 64239, Tel-Aviv, Israel.
Journal:J Neurooncol. 2016 May;127(3):493-502. doi: 10.1007/s11060-015-2025-5. Epub 2015 Dec 31.

11:The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection?
Authors:Li YM, Suki D, Hess K, Sawaya R
Institution:Departments of 1 Neurosurgery and. School of Medicine and Dentistry, Rochester, New York. and.
Journal:J Neurosurg. 2016 Apr;124(4):977-88. doi: 10.3171/2015.5.JNS142087. Epub 2015 Oct 23.

12:Glioblastoma in the elderly: the effect of aggressive and modern therapies on survival.
Authors:Babu R, Komisarow JM, Agarwal VJ, Rahimpour S, Iyer A, Britt D, Karikari IO, Grossi PM, Thomas S, Friedman AH, Adamson C
Institution:Division of Neurosurgery, Department of Surgery, and. Medicine, Durham, North Carolina;
Journal:J Neurosurg. 2016 Apr;124(4):998-1007. doi: 10.3171/2015.4.JNS142200. Epub 2015 Oct 9.

13:Timing of Adjuvant Radiotherapy in Glioblastoma Patients: A Single-Institution Experience With More Than 400 Patients.
Authors:Wang TJ, Jani A, Estrada JP, Ung TH, Chow DS, Soun JE, Saad S, Qureshi YH, Gartrell R, Isaacson SR, Cheng SK, McKhann GM 2nd, Bruce JN, Lassman AB, Sisti MB
Institution:*Department of Radiation Oncology, Columbia University Medical Center, New York, New York;double daggerHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York; section signDepartment of Neurological Surgery, Columbia University Medical Center, New York, New York; paragraph signDepartment of Radiology, Columbia University Medical Center, New York, New York; ||The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York;#Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, New York;**Department of Neurology, Columbia University Medical Center, New York, New York.
Journal:Neurosurgery. 2016 May;78(5):676-82. doi: 10.1227/NEU.0000000000001036.

14:Quality of survival the 1st year with glioblastoma: a longitudinal study of patient-reported quality of life.
Authors:Sagberg LM, Solheim O, Jakola AS
Institution:Department of Neurosurgery, St. Olavs University Hospital; Norway; and. Norway; and.
Journal:J Neurosurg. 2016 Apr;124(4):989-97. doi: 10.3171/2015.4.JNS15194. Epub 2015 Oct 2.

15:Prognostic factors for glioblastoma patients--a clinical population-based study.
Authors:Fekete B, Werlenius K, Orndal C, Rydenhag B
Institution:Department of Clinical Neuroscience and Rehabilitation, The Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Goteborg, Goteborg, Sweden. University of Goteborg, Goteborg, Sweden. Academy, University of Goteborg, Goteborg, Sweden. Institute of Neuroscience and Physiology, University of Goteborg, Goteborg, Sweden. Academy, University of Goteborg, Goteborg, Sweden.
Journal:Acta Neurol Scand. 2016 Jun;133(6):434-41. doi: 10.1111/ane.12481. Epub 2015 Sep 11.

16:HIN-1: a New Epigenetic Biomarker Crucial for Therapy Selection in Glioblastoma Multiforme.
Authors:Herranz M, Padin-Iruegas ME, Martinez-Lago N, Aguin Losada S, Rana-Diez P, Brozos Vazquez E, Carrera JJ, Antunez JR, Ruibal A, Lopez-Lopez R
Institution:Nuclear Medicine Department, Molecular Imaging Program, IDIS, USC, Hospital Clinico Universitario. Fundacion Tejerina, Santiago de Compostela, Spain. michel.herranz.carnero@sergas.es. Embryology Section, University of Vigo, Vigo, Pontevedra, Spain. Compostela, Spain. Compostela, Spain. Compostela, Spain. Compostela, Spain. Spain. Spain. Clinico Universitario. Fundacion Tejerina, Santiago de Compostela, Spain. Compostela, Spain.
Journal:Mol Neurobiol. 2016 Apr;53(3):1802-7. doi: 10.1007/s12035-015-9127-0. Epub 2015 Mar 11.

17:Nimotuzumab, a humanized monoclonal antibody specific for the EGFR, in combination with temozolomide and radiation therapy for newly diagnosed glioblastoma multiforme: First results in Chinese patients.
Authors:Wang Y, Pan L, Sheng XF, Chen S, Dai JZ
Institution:Department of Radiation Oncology, Huashan Hospital, Fudan University, Shanghai, China. China. China. China.
Journal:Asia Pac J Clin Oncol. 2016 Mar;12(1):e23-9. doi: 10.1111/ajco.12166. Epub 2014 Jan 24.

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