August 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Glioblastoma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Glioblastoma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Glioblastoma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Glioblastoma every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Long-term outcomes of concomitant chemoradiotherapy with temozolomide for newly diagnosed glioblastoma patients: A single-center analysis.
Authors:Roh TH, Park HH, Kang SG, Moon JH, Kim EH, Hong CK, Ahn SS, Choi HJ, Cho J, Kim SH, Lee SK, Kim DS, Kim SH, Suh CO, Lee KS, Chang JH
Institution:aYonsei University Graduate School, Seoul bDepartment of Neurosurgery, Ajou University Hospital, Ajou University School of Medicine, Suwon cDepartment of Neurosurgery dDepartment of Radiology eDepartment of Medical Oncology fDepartment of Radiation Oncology gDepartment of Pathology, Yonsei University College of Medicine hBrain Tumor Center, Severance Hospital, Yonsei University Health System iBrain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Journal:Medicine (Baltimore). 2017 Jul;96(27):e7422. doi: 10.1097/MD.0000000000007422.

2:Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy.
Authors:Harris G, Jayamanne D, Wheeler H, Gzell C, Kastelan M, Schembri G, Brazier D, Cook R, Parkinson J, Khasraw M, Louw S, Back M
Institution:Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.; Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Central Coast Cancer Centre, Gosford Hospital, Gosford, New South Wales, Australia.; Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Sydney NeuroOncology Group, Sydney, New South Wales, Australia.; Department of Radiation Oncology, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.; Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia; Sydney NeuroOncology Group, Sydney, New South Wales, Australia.
Journal:Int J Radiat Oncol Biol Phys. 2017 Jul 15;98(4):802-810. doi: 10.1016/j.ijrobp.2017.02.028. Epub 2017 Feb 21.

3:Angiogenesis inhibitors in tackling recurrent glioblastoma.
Authors:Hundsberger T, Reardon DA, Wen PY
Institution:a Department of Neurology and Department of Hematology /Oncology , Cantonal hospital , St. Gallen , Switzerland. Cancer Center , Boston , MA , USA. Cancer Center , Boston , MA , USA.
Journal:Expert Rev Anticancer Ther. 2017 Jun;17(6):507-515. doi: 10.1080/14737140.2017.1322903. Epub 2017 May 2.

4:The role of brachytherapy in the treatment of glioblastoma multiforme.
Authors:Barbarite E, Sick JT, Berchmans E, Bregy A, Shah AH, Elsayyad N, Komotar RJ
Institution:Department of Neurological Surgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, 2nd Floor, Miami, FL, USA.; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Journal:Neurosurg Rev. 2017 Apr;40(2):195-211. doi: 10.1007/s10143-016-0727-6. Epub 2016 May 16.

5:Impact of extent of resection and recurrent surgery on clinical outcome and overall survival in a consecutive series of 170 patients for glioblastoma in intraoperative high field magnetic resonance imaging.
Authors:Coburger J, Wirtz CR, Konig RW
Institution:Department of Neurosurgery, Campus Gunzburg, University of Ulm, Gunzburg, Germany - Germany. Germany.
Journal:J Neurosurg Sci. 2017 Jun;61(3):233-244. doi: 10.23736/S0390-5616.16.03284-7. Epub 2015 Jul 7.

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