Ductal Carcinoma in Situ of the Breast
December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ductal Carcinoma in Situ of the Breast abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ductal Carcinoma in Situ of the Breast. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ductal Carcinoma in Situ of the Breast. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ductal Carcinoma in Situ of the Breast every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Ductal Carcinoma in Situ: Quantitative Preoperative Breast MR Imaging Features Associated with Recurrence after Treatment.
Authors:Luo J, Johnston BS, Kitsch AE, Hippe DS, Korde LA, Javid S, Lee JM, Peacock S, Lehman CD, Partridge SC, Rahbar H
Institution:From the Departments of Radiology (J.L., B.S.J., A.E.K., D.S.H., J.M.L., S.P., S.C.P., H.R.), Medicine, Division of Oncology (L.A.K.), and Surgery, Division of Surgical Oncology (S.J.), University of Washington School of Medicine, Seattle Cancer Care Alliance, 825 Eastlake Ave East, Seattle, WA 98109-1023; and Department of Radiology, Massachusetts General Hospital, Boston, Mass (C.D.L.).
Journal:Radiology. 2017 Dec;285(3):788-797. doi: 10.1148/radiol.2017170587. Epub 2017 Sep 14.

2:Current margin practice and effect on re-excision rates following the publication of the SSO-ASTRO consensus and ABS consensus guidelines: a national prospective study of 2858 women undergoing breast-conserving therapy in the UK and Ireland.
Authors:Tang SS, Kaptanis S, Haddow JB, Mondani G, Elsberger B, Tasoulis MK, Obondo C, Johns N, Ismail W, Syed A, Kissias P, Venn M, Sundaramoorthy S, Irwin G, Sami AS, Elfadl D, Baggaley A, Remoundos DD, Langlands F, Charalampoudis P, Barber Z, Hamilton-Burke WLS, Khan A, Sirianni C, Merker LAG, Saha S, Lane RA, Chopra S, Dupre S, Manning AT, St John ER, Musbahi A, Dlamini N, McArdle CL, Wright C, Murphy JO, Aggarwal R, Dordea M, Bosch K, Egbeare D, Osman H, Tayeh S, Razi F, Iqbal J, Ledwidge SFC, Albert V, Masannat Y
Institution:St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London, England SW17 0QT, UK. Electronic address: stang@doctors.org.uk.; Homerton University Hospital NHS Foundation Trust, Homerton Row, London, England E9 6SR, UK. Electronic address: skaptanis@gmail.com.; Queen Mary University of London, Garrod Building, Turner Street, London, England E1 2AD, UK. Electronic address: Jameshaddow@nhs.net.; Glenfield Hospital, Groby Road, Leicester, England LE3 9QP, UK. Electronic address: jo.mondani@uhl-tr.nhs.uk.; Ninewells Hospital, James Arrott Drive, Dundee, Scotland DD1 9SY, UK. Electronic address: b.elsberger@nhs.net.
Journal:Eur J Cancer. 2017 Oct;84:315-324. doi: 10.1016/j.ejca.2017.07.032. Epub 2017 Aug 30.

3:Maximizing the Clinical Benefit of Anthracyclines in Addition to Taxanes in the Adjuvant Treatment of Early Breast Cancer.
Authors:Curigliano G, Criscitiello C
Institution:Giuseppe Curigliano and Carmen Criscitiello, Istituto Europeo di Oncologia, Milano, Italy. Milano, Italy.
Journal:J Clin Oncol. 2017 Aug 10;35(23):2600-2603. doi: 10.1200/JCO.2017.72.5960. Epub 2017 Jun 29.

4:Quality of Patient Decisions About Breast Reconstruction After Mastectomy.
Authors:Lee CN, Deal AM, Huh R, Ubel PA, Liu YJ, Blizard L, Hunt C, Pignone MP
Institution:Department of Plastic Surgery, College of Medicine, The Ohio State University, Columbus. Cancer Hospital, The Ohio State University, Columbus. Ohio State University, Columbus. North Carolina-Chapel Hill. North Carolina-Chapel Hill. University, Durham, North Carolina. University, Durham, North Carolina. Durham, North Carolina. North Carolina-Chapel Hill. University of North Carolina-Chapel Hill. Austin.
Journal:JAMA Surg. 2017 Aug 1;152(8):741-748. doi: 10.1001/jamasurg.2017.0977.

5:Association of Radiotherapy Boost for Ductal Carcinoma In Situ With Local Control After Whole-Breast Radiotherapy.
Authors:Moran MS, Zhao Y, Ma S, Kirova Y, Fourquet A, Chen P, Hoffman K, Hunt K, Wong J, Halasz LM, Freedman G, Prosnitz R Jr, Yassa M, Nguyen DHA, Hijal T, Haffty BG, Wai ES, Truong PT
Institution:Smilow Cancer Center, Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut. Connecticut. Connecticut. Medicine, Royal Oak, Michigan. Houston. Houston. Institute, Boston, Massachusetts. Institute, Boston, Massachusetts. Maisonneuve-Rosemont, Montreal, Quebec, Canada. Maisonneuve-Rosemont, Montreal, Quebec, Canada. Quebec, Canada. Brunswick, New Jersey. British Columbia, Canada. British Columbia, Canada.
Journal:JAMA Oncol. 2017 Aug 1;3(8):1060-1068. doi: 10.1001/jamaoncol.2016.6948.

6:Health-related behaviors and mortality outcomes in women diagnosed with ductal carcinoma in situ.
Authors:Veal CT, Hart V, Lakoski SG, Hampton JM, Gangnon RE, Newcomb PA, Higgins ST, Trentham-Dietz A, Sprague BL
Institution:Department of Surgery and Office of Health Promotion Research, University of Vermont, 1 South Prospect Street, Rm. 4428, Burlington, VT, 05401, USA. bsprague@uvm.edu.; Vermont Center for Behavior and Health, University of Vermont, Burlington, VT, USA. bsprague@uvm.edu.; Department of Clinical Cancer Prevention & Cardiology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.; Department of Population Health Sciences and Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Journal:J Cancer Surviv. 2017 Jun;11(3):320-328. doi: 10.1007/s11764-016-0590-z. Epub 2017 Jan 5.

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