Bladder Cancer
February 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Bladder Cancer abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Bladder Cancer. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Bladder Cancer. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Bladder Cancer every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Kidney, Ureteral, and Bladder Cancer: A Primer for the Internist.
Authors:Arora HC, Fascelli M, Zhang JH, Isharwal S, Campbell SC
Institution:Center for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Q10-1, Cleveland, OH 44195, USA. Electronic address:
Journal:Med Clin North Am. 2018 Mar;102(2):231-249. doi: 10.1016/j.mcna.2017.10.002.

2:Male Neobladder.
Authors:Pietzak EJ, Donahue TF, Bochner BH
Institution:Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. New York, NY, USA. New York, NY, USA. Electronic address:
Journal:Urol Clin North Am. 2018 Feb;45(1):37-48. doi: 10.1016/j.ucl.2017.09.003.

3:Diabetes mellitus and the risk of bladder cancer: A PRISMA-compliant meta-analysis of cohort studies.
Authors:Xu Y, Huo R, Chen X, Yu X
Institution:Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal:Medicine (Baltimore). 2017 Nov;96(46):e8588. doi: 10.1097/MD.0000000000008588.

4:Bladder Cancer: Diagnosis and Treatment.
Authors:DeGeorge KC, Holt HR, Hodges SC
Institution:University of Virginia School of Medicine, Charlottesville, VA, USA.
Journal:Am Fam Physician. 2017 Oct 15;96(8):507-514.

5:The efficacy of Apaziquone in the treatment of bladder cancer.
Authors:Carames Masana F, de Reijke TM
Institution:a Department of Urology , Complexo Hospitalario Universitario de A Coruna , A Coruna , Spain.
Journal:Expert Opin Pharmacother. 2017 Nov;18(16):1781-1788. doi: 10.1080/14656566.2017.1392510. Epub 2017 Oct 20.

6:Atezolizumab in invasive and metastatic urothelial carcinoma.
Authors:Crist M, Balar A
Institution:a Laura & Isaac Perlmutter Cancer Center , NYU Langone Medical Center , New York , NY , USA. Cancer Center , NYU Langone Medical Center , New York , NY , USA.
Journal:Expert Rev Clin Pharmacol. 2017 Dec;10(12):1295-1301. doi: 10.1080/17512433.2017.1389275. Epub 2017 Oct 30.

7:Management of Muscle-Invasive Urothelial Cancer and the Emerging Role of Immunotherapy in Advanced Urothelial Cancer.
Authors:Giridhar KV, Kohli M
Institution:Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN. Electronic address:
Journal:Mayo Clin Proc. 2017 Oct;92(10):1564-1582. doi: 10.1016/j.mayocp.2017.07.010.

8:Bladder cancer to patients younger than 30 years: a retrospective study and review of the literature.
Authors:Katafigiotis I, Sfoungaristos S, Martini A, Stravodimos K, Anastasiou I, Mykoniatis I, Duvdevani M, Constantinides C
Institution:1 University Urology Clinic, Laiko Hospital, Athens - Greece. Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan - Italy. Thessaloniki - Greece.
Journal:Urologia. 2017 Oct 25;84(4):231-235. doi: 10.5301/uj.5000264. Epub 2017 Sep 5.

9:The Cancer of the Bladder Risk Assessment (COBRA) score: Estimating mortality after radical cystectomy.
Authors:Welty CJ, Sanford TH, Wright JL, Carroll PR, Cooperberg MR, Meng MV, Porten SP
Institution:Helen Diller Family Comprehensive Cancer Center, Department of Urology, University of California, San Francisco, California.; Department of Urology, University of Washington School of Medicine, Seattle, Washington.
Journal:Cancer. 2017 Dec 1;123(23):4574-4582. doi: 10.1002/cncr.30918. Epub 2017 Sep 7.

10:Bladder-Preserving Therapy Patterns of Care: A Survey of US Radiation Oncologists.
Authors:Solanki AA, Martin B, Korpics M, Small C, Harkenrider MM, Mitin T
Institution:Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois. Electronic address: Maywood, Illinois. Chicago, Maywood, Illinois. Chicago, Maywood, Illinois. Chicago, Maywood, Illinois. Oregon.
Journal:Int J Radiat Oncol Biol Phys. 2017 Oct 1;99(2):383-387. doi: 10.1016/j.ijrobp.2017.04.009. Epub 2017 Apr 11.

11:Prospects and progress of immunotherapy for bladder cancer.
Authors:Boegemann M, Aydin AM, Bagrodia A, Krabbe LM
Institution:a Department of Urology , University of Muenster Medical Center , Muenster , Germany. Dallas , TX , USA. Turkey. Dallas , TX , USA. Germany. Dallas , TX , USA.
Journal:Expert Opin Biol Ther. 2017 Nov;17(11):1417-1431. doi: 10.1080/14712598.2017.1366445. Epub 2017 Aug 23.

12:Nivolumab for the treatment of bladder cancer.
Authors:Hakenberg OW
Institution:a Department of Urology , Rostock University , Rostock , Germany.
Journal:Expert Opin Biol Ther. 2017 Oct;17(10):1309-1315. doi: 10.1080/14712598.2017.1353076. Epub 2017 Jul 24.

13:Physical activity in the prevention and management of bladder cancer.
Authors:Shephard RJ
Institution:Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada -
Journal:J Sports Med Phys Fitness. 2017 Oct;57(10):1359-1366. doi: 10.23736/S0022-4707.17.06830-X. Epub 2017 Jan 23.

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