Peripheral Neuropathy
October 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Peripheral Neuropathy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Peripheral Neuropathy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Peripheral Neuropathy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Peripheral Neuropathy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Adipose-Derived Mesenchymal Stem Cells in the Treatment of Diabetic Foot Ulcers: A Review of Preclinical and Clinical Studies.
Authors:Álvaro-Afonso FJ, Sanz-Corbalán I, Lázaro-Martínez JL, Kakagia D, Papanas N
Institution:Diabetic Foot Unit, University Podiatric Clinic, Edificio Facultad de Medicina, 16734Complutense University of Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Mad Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece.
Journal:Angiology. 2020 Oct;71(9):853-863. doi: 10.1177/0003319720939467. Epub 2020 Jul 29.

2:Compounding Pearls -- Wound Care: Diabetic Foot Ulcers, Part 2.
Authors:Riepl M
Institution:Gateway Pharmacy North, Bismarck, North Dakota.
Journal:Int J Pharm Compd. 2020 Jul-Aug;24(4):278-281.

3:A Methodological Assessment of Diabetic Foot Syndrome Clinical Practice Guidelines.
Authors:Tan MKH, Goodall R, Hughes W, Langridge B, Shalhoub J, Davies AH
Institution:Academic Section of Vascular Surgery, Division of Surgery, Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address:
Journal:Eur J Vasc Endovasc Surg. 2020 Aug;60(2):274-281. doi: 10.1016/j.ejvs.2020.04.028. Epub 2020 Jul 4.

4:Risk Factors for Chronic Diabetes Patients.
Authors:Metzker O, Magoev K, Yanishevskiy S, Yakovlev A, Kopanitsa G
Institution:ITMO University, Saint Petersburg, Russia.
Journal:Stud Health Technol Inform. 2020 Jun 16;270:1379-1380. doi: 10.3233/SHTI200451.

5:An Overview of Ozone Therapy for Treating Foot Ulcers in Patients With Diabetes.
Authors:Wen Q, Chen Q
Institution:Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China. Electronic address:
Journal:Am J Med Sci. 2020 Aug;360(2):112-119. doi: 10.1016/j.amjms.2020.05.012. Epub 2020 May 13.

6:Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus.
Authors:Naranjo C, Ortega-Jiménez P, Del Reguero L, Moratalla G, Failde I
Institution:University Hospital 'Puerta del Mar', Cadiz, Spain. Electronic address: The Observatory of Pain, University of Cadiz, Spain; Preventive Medicine and Public Health Area, University of Cadiz, Spain; Biomedical Research and Innovation Institute of Cadiz (INiBICA), Spain. Elec
Journal:Diabetes Res Clin Pract. 2020 Jul;165:108236. doi: 10.1016/j.diabres.2020.108236. Epub 2020 May 26.

7:A systematic review and meta-analysis of the efficacy of acupuncture and electroacupuncture against chemotherapy-induced peripheral neuropathy.
Authors:Hwang MS, Lee HY, Choi TY, Lee JH, Ko YS, Jo DC, Do K, Lee JH, Park TY
Institution:3rd Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Yangsan. Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon, Republic of Korea.
Journal:Medicine (Baltimore). 2020 Apr;99(17):e19837. doi: 10.1097/MD.0000000000019837.

8:Optimizing footwear for the diabetic foot: Data-driven custom-made footwear concepts and their effect on pressure relief to prevent diabetic foot ulceration.
Authors:Zwaferink JBJ, Custers W, Paardekooper I, Berendsen HA, Bus SA
Institution:Department of Rehabilitation Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Journal:PLoS One. 2020 Apr 23;15(4):e0224010. doi: 10.1371/journal.pone.0224010. eCollection 2020.

9:Offloading for the Diabetic Foot: Considerations and Implications.
Authors:Yalla SV, Crews RT, Patel NA, Cheung T, Wu S
Institution:Podiatric Surgery and Applied Biomechanics, Center for Lower Extremity Ambulatory Research (CLEAR), Dr. William M. Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and S
Journal:Clin Podiatr Med Surg. 2020 Apr;37(2):371-384. doi: 10.1016/j.cpm.2019.12.006. Epub 2020 Jan 31.

10:Orthoplastic Approach for Surgical Treatment of Diabetic Foot Ulcers.
Authors:Pehde CE, Bennett J, Kingston M
Institution:College of Podiatric Medicine and Surgery, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, USA. Electronic address:
Journal:Clin Podiatr Med Surg. 2020 Apr;37(2):215-230. doi: 10.1016/j.cpm.2019.12.001. Epub 2020 Jan 30.

11:Free-Flap Reconstruction for Diabetic Lower Extremity Limb Salvage.
Authors:Lee ZH, Daar DA, Stranix JT, Anzai L, Levine JP, Saadeh PB, Thanik VD
Institution:Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, New York. Electronic address:
Journal:J Surg Res. 2020 Apr;248:165-170. doi: 10.1016/j.jss.2019.12.008. Epub 2020 Jan 7.

12:Characteristics and risk factors of bortezomib induced peripheral neuropathy: A systematic review of phase III trials.
Authors:Li T, Timmins HC, King T, Kiernan MC, Goldstein D, Park SB
Institution:Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Journal:Hematol Oncol. 2020 Aug;38(3):229-243. doi: 10.1002/hon.2706. Epub 2020 Jan 27.

13:Safety and tolerability of cryocompression as a method of enhanced limb hypothermia to reduce taxane-induced peripheral neuropathy.
Authors:Bandla A, Tan S, Kumarakulasinghe NB, Huang Y, Ang S, Magarajah G, Hairom Z, Lim JSJ, Wong A, Chan G, Ngoi N, Ang E, Lee YM, Chan A, Lee SC, Thakor N, Wilder-Smith E, Sundar R
Institution:The N.1 Institute for Health, National University of Singapore, Singapore, Singapore.
Journal:Support Care Cancer. 2020 Aug;28(8):3691-3699. doi: 10.1007/s00520-019-05177-2. Epub 2019 Dec 6.

14:Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial.
Authors:Asadi S, Gholami MS, Siassi F, Qorbani M, Sotoudeh G
Institution:Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Journal:Phytother Res. 2020 Apr;34(4):896-903. doi: 10.1002/ptr.6571. Epub 2019 Dec 1.

15:A systematic review of multidisciplinary teams to reduce major amputations for patients with diabetic foot ulcers.
Authors:Musuuza J, Sutherland BL, Kurter S, Balasubramanian P, Bartels CM, Brennan MB
Institution:Department of Medicine, University of Wisconsin-Madison, Madison, Wisc; Department of Medicine, William S. Middleton Memorial Veterans Hospital, Madison, Wisc. Electronic address: mbbrennan@medicine.wi
Journal:J Vasc Surg. 2020 Apr;71(4):1433-1446.e3. doi: 10.1016/j.jvs.2019.08.244. Epub 2019 Oct 30.

16:A Narrative Review of Complementary Nutritional Supplements for Chemotherapy-induced Peripheral Neuropathy.
Authors:Liu YW, Liu CT, Su YL, Tsai MY
Journal:Altern Ther Health Med. 2020 Jul;26(4):43-49.

17:Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data.
Authors:Gewandter JS, Kleckner AS, Marshall JH, Brown JS, Curtis LH, Bautista J, Dworkin RH, Kleckner IR, Kolb N, Mohile SG, Mustian KM
Institution:Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, NY, USA. Cancer Control, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Journal:Support Care Cancer. 2020 Jun;28(6):2553-2562. doi: 10.1007/s00520-019-05063-x. Epub 2019 Sep 7.

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What Our Customers Are Saying...

"This is the BEST informational and reference book pertaining to my long-time ailment 'Peripheral Neuropathy'. I have researched this relatively obscure subject for seven years. The MediFocus Guidebook on Peripheral Neuropathy is easy reading, concise, and contains great references."
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