Reflex Sympathetic Dystrophy
September 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Reflex Sympathetic Dystrophy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Reflex Sympathetic Dystrophy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Reflex Sympathetic Dystrophy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Reflex Sympathetic Dystrophy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Complex Regional Pain Syndrome.
Authors:Lloyd ECO, Dempsey B, Romero L
Institution:Southern Colorado Family Medicine Residency, Pueblo, CO, USA.
Journal:Am Fam Physician. 2021 Jul 1;104(1):49-55.

2:Use of bisphosphonates in a retrospective case series of children and adolescents with complex regional pain syndrome.
Authors:Walfish L, Sbrocchi AM, Rivera G, Ricaurte Gracia YLN, Mohamed N, González Cárdenas VH, Stoopler M, Ingelmo P
Institution:Faculty of Medicine, McGill University, Montreal, QC, Canada. Center, Montreal, QC, Canada. Colombia. Chronic Pain, Montreal Children's Hospital, McGill University Health Center, Montreal, QC, Canada. Colombia. Cobos Medical Center, Hospital Universitario de la Samaritana, Bogotá, Colombia.
Journal:Paediatr Anaesth. 2021 Aug;31(8):871-877. doi: 10.1111/pan.14207. Epub 2021 Jun 3.

3:Dorsal Root Ganglion Stimulation for the Treatment of Non-Complex Regional Pain Syndrome Related Chronic Pain Syndromes: A Systematic Review.
Authors:Stelter B, Karri J, Marathe A, Abd-Elsayed A
Institution:Department of Anesthesia, Division of Pain Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Houston, TX, USA. Houston, TX, USA.
Journal:Neuromodulation. 2021 Jun;24(4):622-633. doi: 10.1111/ner.13361. Epub 2021 Jan 26.

4:Randomized Prospective Study in Patients With Complex Regional Pain Syndrome of the Upper Limb With High-Frequency Spinal Cord Stimulation (10-kHz) and Low-Frequency Spinal Cord Stimulation.
Authors:Canós-Verdecho A, Abejón D, Robledo R, Izquierdo R, Bermejo A, Gallach E, Argente P, Peraita-Costa I, Morales-Suárez-Varela M
Institution:Multidisciplinary Pain Management Unit, Hospital Universitari i Politècnic La Fe, Valencia, Spain. Spain. Spain. Valencia, Spain. Spain. Valencia, Spain. Spain. Valencia, Spain. Valencia, Spain. Spain. Valencia, Spain.
Journal:Neuromodulation. 2021 Apr;24(3):448-458. doi: 10.1111/ner.13358. Epub 2021 Jan 18.

5:Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty.
Authors:Jacques H, Jérôme V, Antoine C, Lucile S, Valérie D, Amandine L, Theofylaktos K, Olivier B
Institution:Department of Orthopaedics and Traumatology, Centre Hospitalier EpiCURA, Sites Hornu/Baudour, Hainaut, Belgium.
Journal:Int Orthop. 2021 May;45(5):1155-1162. doi: 10.1007/s00264-020-04936-9. Epub 2021 Jan 12.

6:Prevalence of autonomic nervous system dysfunction in complex regional pain syndrome.
Authors:Lee HJ, Lee KH, Moon JY, Kim YC
Institution:Anesthesiology and Pain Medicine, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of). Seoul, Korea (the Republic of). Seoul, Korea (the Republic of) Seoul, Korea (the Republic of). Seoul, Korea (the Republic of). Seoul, Korea (the Republic of).
Journal:Reg Anesth Pain Med. 2021 Mar;46(3):196-202. doi: 10.1136/rapm-2020-101644. Epub 2021 Jan 8.

7:Screening and diagnostic tools for complex regional pain syndrome: a systematic review.
Authors:Mesaroli G, Hundert A, Birnie KA, Campbell F, Stinson J
Institution:The Hospital for Sick Children, Department of Rehabilitation, and the University of Toronto, Department of Physical Therapy, Toronto, ON, Canada. The Hospital for Sick Children, Child?Health Evaluative Sciences and the University of Toronto, Lawrence S. Bloomberg Faculty of Nursing, Toronto, ON, Canada.
Journal:Pain. 2021 May 1;162(5):1295-1304. doi: 10.1097/j.pain.0000000000002146.

8:Direct Sciatic Nerve Electrical Stimulation for Complex Regional Pain Syndrome Type 1.
Authors:Buwembo J, Munson R, Rizvi SA, Ijaz A, Gupta S
Institution:Saskatchewan Health Authority, Regina, SK, Canada.
Journal:Neuromodulation. 2021 Aug;24(6):1075-1082. doi: 10.1111/ner.13294. Epub 2020 Nov 10.

9:Direct Peripheral Nerve Stimulation for the Treatment of Complex Regional Pain Syndrome: A 30-Year Review.
Authors:Chmiela MA, Hendrickson M, Hale J, Liang C, Telefus P, Sagir A, Stanton-Hicks M
Institution:Department of Pain Management, Cleveland Clinic Foundation, Cleveland, OH, USA. Foundation, Cleveland, OH, USA. Foundation, Cleveland, OH, USA. Foundation, Cleveland, OH, USA.
Journal:Neuromodulation. 2021 Aug;24(6):971-982. doi: 10.1111/ner.13295. Epub 2020 Oct 24.

10:Photophobia in complex regional pain syndrome: visual discomfort is greater on the affected than unaffected side.
Authors:Drummond PD, Finch PM
Institution:Discipline of Psychology, College of Science, Health, Engineering and Education, Murdoch University, South Street, Murdoch, WA, Australia.
Journal:Pain. 2021 Apr 1;162(4):1233-1240. doi: 10.1097/j.pain.0000000000002118.

11:The Tourniquet Ischemia Test in the Diagnosis of Complex Regional Pain Syndrome.
Authors:Lambeck J, Kesenheimer EM, Kleinmann B, Reinhard M
Institution:Department of Neurology and Neurophysiology, University Medical Center Freiburg, Freiburg, Germany. Freiburg, Germany. Switzerland. Germany. Freiburg, Germany. Switzerland. Academic Teaching Hospital of the University of Tübingen, Esslingen, Germany.
Journal:Pain Pract. 2021 Mar;21(3):308-315. doi: 10.1111/papr.12960. Epub 2020 Oct 31.

12:Utilization of Concurrent Dorsal Root Ganglion Stimulation and Dorsal Column Spinal Cord Stimulation in Complex Regional Pain Syndrome.
Authors:Ghosh P, Gungor S
Institution:Division of Pain Medicine, Department of Anesthesiology, Critical Care and Pain Management, Hospital for Special Surgery, New York, NY, USA.
Journal:Neuromodulation. 2021 Jun;24(4):769-773. doi: 10.1111/ner.13144. Epub 2020 Mar 11.

13:Cost-Effectiveness of Dorsal Root Ganglion Stimulation or Spinal Cord Stimulation for Complex Regional Pain Syndrome.
Authors:Mekhail N, Deer TR, Poree L, Staats PS, Burton AW, Connolly AT, Karst E, Mehanny DS, Saweris Y, Levy RM
Institution:Department of Evidence-Based Pain Management Research, Cleveland Clinic, Cleveland, OH, USA. OH, USA. OH, USA.
Journal:Neuromodulation. 2021 Jun;24(4):708-718. doi: 10.1111/ner.13134. Epub 2020 Mar 9.

14:The long-term effect of complex regional pain syndrome type 1 on disability and quality of life after foot injury.
Authors:Mouraux D, Lenoir C, Tuna T, Brassinne E, Sobczak S
Institution:Department of Physical Therapy and Rehabilitation, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium. de Bruxelles (ULB), Brussels, Belgium. UK. Belgium. Bruxelles (ULB), Brussels, Belgium. de Bruxelles (ULB), Brussels, Belgium. de Bruxelles (ULB), Brussels, Belgium. Trois-Rivières, Canada. Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, Canada.
Journal:Disabil Rehabil. 2021 Apr;43(7):967-975. doi: 10.1080/09638288.2019.1650295. Epub 2019 Aug 14.

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What Our Customers Are Saying...

"Your MediFocus Guidebook on Reflex Sympathetic Dystrophy helped me understand my diagnosis. It gave me a clear insight into what the disorder is about and a way to find out about the treatments for RSD. It also gave me a way to inform those around me. Anyone who has RSD or knows someone who is diagnosed with RSD needs this easy to read and understand Guidebook."
Casper, Wyoming

"I was recently diagnosed with RSD and I purchased the MediFocus Guidebook on this condition. The book was very well written and I immediately gave it to one of my doctors. With the help of the Guidebook, we were able to come up with a better treatment plan to help alleviate my pain. Sincere thanks."
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