Parkinson's Disease
February 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study.
Authors:Kurcova S, Bardon J, Vastik M, Vecerkova M, Frolova M, Hvizdosova L, Nevrly M, Mensikova K, Otruba P, Krahulik D, Kurca E, Sivak S, Zapletalova J, Kanovsky P
Institution:Department of Neurology. Dentistry, Palacky University Olomouc, Czech Republic. in Bratislava and University Hospital in Martin, Slovak Republic. in Bratislava and University Hospital in Martin, Slovak Republic. University Olomouc, Czech Republic.
Journal:Medicine (Baltimore). 2018 Feb;97(5):e9750. doi: 10.1097/MD.0000000000009750.

2:Handwriting training in Parkinson's disease: A trade-off between size, speed and fluency.
Authors:Nackaerts E, Broeder S, Pereira MP, Swinnen SP, Vandenberghe W, Nieuwboer A, Heremans E
Institution:Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Journal:PLoS One. 2017 Dec 22;12(12):e0190223. doi: 10.1371/journal.pone.0190223. eCollection 2017.

3:Feasibility of large-scale deployment of multiple wearable sensors in Parkinson's disease.
Authors:Silva de Lima AL, Hahn T, Evers LJW, de Vries NM, Cohen E, Afek M, Bataille L, Daeschler M, Claes K, Boroojerdi B, Terricabras D, Little MA, Baldus H, Bloem BR, Faber MJ
Institution:Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; CAPES Foundation, Ministry of Education of Brazil, Brasilia/DF, Brazil.; Intel, Advanced Analytics, Tel Aviv, Israel.; The Michael J Fox Foundation for Parkinson's Research, New York, United States of America.; UCB Biopharma, Brussels, Belgium.
Journal:PLoS One. 2017 Dec 20;12(12):e0189161. doi: 10.1371/journal.pone.0189161. eCollection 2017.

4:Sleep-wake functions and quality of life in patients with subthalamic deep brain stimulation for Parkinson's disease.
Authors:Bargiotas P, Eugster L, Oberholzer M, Debove I, Lachenmayer ML, Mathis J, Pollo C, Schupbach WMM, Bassetti CL
Institution:Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.; Department of Neurosurgery, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.
Journal:PLoS One. 2017 Dec 18;12(12):e0190027. doi: 10.1371/journal.pone.0190027. eCollection 2017.

5:Striatal dopamine in Parkinson disease: A meta-analysis of imaging studies.
Authors:Kaasinen V, Vahlberg T
Institution:Division of Clinical Neurosciences, Turku University Hospital.
Journal:Ann Neurol. 2017 Dec;82(6):873-882. doi: 10.1002/ana.25103. Epub 2017 Dec 5.

6:Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease: A Randomized Clinical Trial.
Authors:Bond AE, Shah BB, Huss DS, Dallapiazza RF, Warren A, Harrison MB, Sperling SA, Wang XQ, Gwinn R, Witt J, Ro S, Elias WJ
Institution:Department of Neurosurgery, University of Virginia Health Science Center, Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Center, Charlottesville. Charlottesville.
Journal:JAMA Neurol. 2017 Dec 1;74(12):1412-1418. doi: 10.1001/jamaneurol.2017.3098.

7:Superselective Thalamotomy in the Most Lateral Part of the Ventralis Intermedius Nucleus for Controlling Essential and Parkinsonian Tremor.
Authors:Hirato M, Miyagishima T, Takahashi A, Yoshimoto Y
Institution:Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. Electronic address: Maebashi, Gunma, Japan. Maebashi, Gunma, Japan.
Journal:World Neurosurg. 2018 Jan;109:e630-e641. doi: 10.1016/j.wneu.2017.10.042. Epub 2017 Oct 17.

8:Pimavanserin: novel pharmacotherapy for Parkinson's disease psychosis.
Authors:Sahli ZT, Tarazi FI
Institution:a Department of Psychiatry and Neuroscience Program , Harvard Medical School, McLean Hospital , Belmont , MA , USA. McLean Hospital , Belmont , MA , USA.
Journal:Expert Opin Drug Discov. 2018 Jan;13(1):103-110. doi: 10.1080/17460441.2018.1394838. Epub 2017 Oct 31.

9:Recent advances in discovery and development of natural products as source for anti-Parkinson's disease lead compounds.
Authors:Zhang H, Bai L, He J, Zhong L, Duan X, Ouyang L, Zhu Y, Wang T, Zhang Y, Shi J
Institution:Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China. Electronic address:; State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China. Electronic address:
Journal:Eur J Med Chem. 2017 Dec 1;141:257-272. doi: 10.1016/j.ejmech.2017.09.068. Epub 2017 Sep 30.

10:Dopamine dysregulation syndrome in Parkinson's disease: a systematic review of published cases.
Authors:Warren N, O'Gorman C, Lehn A, Siskind D
Institution:School of Medicine, University of Queensland, Brisbane, Queensland, Australia. Brisbane, Queensland, Australia. Australia. Australia. Brisbane, Queensland, Australia.
Journal:J Neurol Neurosurg Psychiatry. 2017 Dec;88(12):1060-1064. doi: 10.1136/jnnp-2017-315985. Epub 2017 Oct 10.

11:Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease.
Authors:Francardo V, Schmitz Y, Sulzer D, Cenci MA
Institution:Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden. Electronic address: Center: Division of Molecular Therapeutics, New York State Psychiatric Institute, New York 10032, NY, USA. Center: Division of Molecular Therapeutics, New York State Psychiatric Institute, New York 10032, NY, USA. Lund University, Lund, Sweden. Electronic address:
Journal:Exp Neurol. 2017 Dec;298(Pt B):137-147. doi: 10.1016/j.expneurol.2017.10.001. Epub 2017 Oct 5.

12:Therapeutic approaches to target alpha-synuclein pathology.
Authors:Brundin P, Dave KD, Kordower JH
Institution:Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: MI 49503, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.
Journal:Exp Neurol. 2017 Dec;298(Pt B):225-235. doi: 10.1016/j.expneurol.2017.10.003. Epub 2017 Oct 4.

13:Compensatory mechanisms in Parkinson's disease: Circuits adaptations and role in disease modification.
Authors:Blesa J, Trigo-Damas I, Dileone M, Del Rey NL, Hernandez LF, Obeso JA
Institution:HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Biomedical Research Center of Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain. Electronic address:; HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Biomedical Research Center of Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain. Electronic address:
Journal:Exp Neurol. 2017 Dec;298(Pt B):148-161. doi: 10.1016/j.expneurol.2017.10.002. Epub 2017 Oct 4.

14:Effects of Progressive Resistance Training on Cardiovascular Autonomic Regulation in Patients With Parkinson Disease: A Randomized Controlled Trial.
Authors:Kanegusuku H, Silva-Batista C, Pecanha T, Nieuwboer A, Silva ND Jr, Costa LA, de Mello MT, Piemonte ME, Ugrinowitsch C, Forjaz CL
Institution:School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: Brazil. Brazil. Belgium. Brazil. Brazil. Brazil. Brazil. Brazil.
Journal:Arch Phys Med Rehabil. 2017 Nov;98(11):2134-2141. doi: 10.1016/j.apmr.2017.06.009. Epub 2017 Jul 10.

15:Clinical approaches to the development of a neuroprotective therapy for PD.
Authors:Olanow CW, Kieburtz K, Katz R
Institution:Clintrex LLC, United States; Dept of Neurology, Dept of Neuroscience, Mount Sinai School of Medicine, New York, NY, United States. Electronic address: States. States.
Journal:Exp Neurol. 2017 Dec;298(Pt B):246-251. doi: 10.1016/j.expneurol.2017.06.018. Epub 2017 Jun 13.

16:Algorithms for the treatment of motor problems in Parkinson's disease.
Authors:Dietrichs E, Odin P
Institution:Department of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway. Sweden.
Journal:Acta Neurol Scand. 2017 Nov;136(5):378-385. doi: 10.1111/ane.12733. Epub 2017 Jan 30.

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