Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
|Authors:||Kurcova S, Bardon J, Vastik M, Vecerkova M, Frolova M, Hvizdosova L, Nevrly M, Mensikova K, Otruba P, Krahulik D, Kurca E, Sivak S, Zapletalova J, Kanovsky P|
|Institution:||Department of Neurology. Dentistry, Palacky University Olomouc, Czech Republic. in Bratislava and University Hospital in Martin, Slovak Republic. in Bratislava and University Hospital in Martin, Slovak Republic. University Olomouc, Czech Republic.|
|Journal:||Medicine (Baltimore). 2018 Feb;97(5):e9750. doi: 10.1097/MD.0000000000009750.|
|Authors:||Nackaerts E, Broeder S, Pereira MP, Swinnen SP, Vandenberghe W, Nieuwboer A, Heremans E|
|Institution:||Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.|
|Journal:||PLoS One. 2017 Dec 22;12(12):e0190223. doi: 10.1371/journal.pone.0190223. eCollection 2017.|
|Authors:||Silva de Lima AL, Hahn T, Evers LJW, de Vries NM, Cohen E, Afek M, Bataille L, Daeschler M, Claes K, Boroojerdi B, Terricabras D, Little MA, Baldus H, Bloem BR, Faber MJ|
|Institution:||Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; CAPES Foundation, Ministry of Education of Brazil, Brasilia/DF, Brazil.; Intel, Advanced Analytics, Tel Aviv, Israel.; The Michael J Fox Foundation for Parkinson's Research, New York, United States of America.; UCB Biopharma, Brussels, Belgium.|
|Journal:||PLoS One. 2017 Dec 20;12(12):e0189161. doi: 10.1371/journal.pone.0189161. eCollection 2017.|
|Authors:||Bargiotas P, Eugster L, Oberholzer M, Debove I, Lachenmayer ML, Mathis J, Pollo C, Schupbach WMM, Bassetti CL|
|Institution:||Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.; Department of Neurosurgery, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.|
|Journal:||PLoS One. 2017 Dec 18;12(12):e0190027. doi: 10.1371/journal.pone.0190027. eCollection 2017.|
|Authors:||Kaasinen V, Vahlberg T|
|Institution:||Division of Clinical Neurosciences, Turku University Hospital.|
|Journal:||Ann Neurol. 2017 Dec;82(6):873-882. doi: 10.1002/ana.25103. Epub 2017 Dec 5.|
|Authors:||Bond AE, Shah BB, Huss DS, Dallapiazza RF, Warren A, Harrison MB, Sperling SA, Wang XQ, Gwinn R, Witt J, Ro S, Elias WJ|
|Institution:||Department of Neurosurgery, University of Virginia Health Science Center, Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Charlottesville. Center, Charlottesville. Charlottesville.|
|Journal:||JAMA Neurol. 2017 Dec 1;74(12):1412-1418. doi: 10.1001/jamaneurol.2017.3098.|
|Authors:||Hirato M, Miyagishima T, Takahashi A, Yoshimoto Y|
|Institution:||Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. Electronic address: firstname.lastname@example.org. Maebashi, Gunma, Japan. Maebashi, Gunma, Japan.|
|Journal:||World Neurosurg. 2018 Jan;109:e630-e641. doi: 10.1016/j.wneu.2017.10.042. Epub 2017 Oct 17.|
|Authors:||Sahli ZT, Tarazi FI|
|Institution:||a Department of Psychiatry and Neuroscience Program , Harvard Medical School, McLean Hospital , Belmont , MA , USA. McLean Hospital , Belmont , MA , USA.|
|Journal:||Expert Opin Drug Discov. 2018 Jan;13(1):103-110. doi: 10.1080/17460441.2018.1394838. Epub 2017 Oct 31.|
|Authors:||Zhang H, Bai L, He J, Zhong L, Duan X, Ouyang L, Zhu Y, Wang T, Zhang Y, Shi J|
|Institution:||Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China. Electronic address: email@example.com.; State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China. Electronic address: firstname.lastname@example.org.|
|Journal:||Eur J Med Chem. 2017 Dec 1;141:257-272. doi: 10.1016/j.ejmech.2017.09.068. Epub 2017 Sep 30.|
|Authors:||Warren N, O'Gorman C, Lehn A, Siskind D|
|Institution:||School of Medicine, University of Queensland, Brisbane, Queensland, Australia. Brisbane, Queensland, Australia. Australia. Australia. Brisbane, Queensland, Australia.|
|Journal:||J Neurol Neurosurg Psychiatry. 2017 Dec;88(12):1060-1064. doi: 10.1136/jnnp-2017-315985. Epub 2017 Oct 10.|
|Authors:||Francardo V, Schmitz Y, Sulzer D, Cenci MA|
|Institution:||Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden. Electronic address: Veronica.Francardo@med.lu.se. Center: Division of Molecular Therapeutics, New York State Psychiatric Institute, New York 10032, NY, USA. Center: Division of Molecular Therapeutics, New York State Psychiatric Institute, New York 10032, NY, USA. Lund University, Lund, Sweden. Electronic address: Angela.Cenci_Nilsson@med.lu.se.|
|Journal:||Exp Neurol. 2017 Dec;298(Pt B):137-147. doi: 10.1016/j.expneurol.2017.10.001. Epub 2017 Oct 5.|
|Authors:||Brundin P, Dave KD, Kordower JH|
|Institution:||Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: Patrik.Brundin@vai.org. MI 49503, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.|
|Journal:||Exp Neurol. 2017 Dec;298(Pt B):225-235. doi: 10.1016/j.expneurol.2017.10.003. Epub 2017 Oct 4.|
|Authors:||Blesa J, Trigo-Damas I, Dileone M, Del Rey NL, Hernandez LF, Obeso JA|
|Institution:||HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Biomedical Research Center of Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain. Electronic address: email@example.com.; HM CINAC, Hospital Universitario HM Puerta del Sur, Mostoles, Madrid, Spain; Biomedical Research Center of Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain. Electronic address: firstname.lastname@example.org.|
|Journal:||Exp Neurol. 2017 Dec;298(Pt B):148-161. doi: 10.1016/j.expneurol.2017.10.002. Epub 2017 Oct 4.|
|Authors:||Kanegusuku H, Silva-Batista C, Pecanha T, Nieuwboer A, Silva ND Jr, Costa LA, de Mello MT, Piemonte ME, Ugrinowitsch C, Forjaz CL|
|Institution:||School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: email@example.com. Brazil. Brazil. Belgium. Brazil. Brazil. Brazil. Brazil. Brazil.|
|Journal:||Arch Phys Med Rehabil. 2017 Nov;98(11):2134-2141. doi: 10.1016/j.apmr.2017.06.009. Epub 2017 Jul 10.|
|Authors:||Olanow CW, Kieburtz K, Katz R|
|Institution:||Clintrex LLC, United States; Dept of Neurology, Dept of Neuroscience, Mount Sinai School of Medicine, New York, NY, United States. Electronic address: Warren.firstname.lastname@example.org. States. States.|
|Journal:||Exp Neurol. 2017 Dec;298(Pt B):246-251. doi: 10.1016/j.expneurol.2017.06.018. Epub 2017 Jun 13.|
|Authors:||Dietrichs E, Odin P|
|Institution:||Department of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway. Sweden.|
|Journal:||Acta Neurol Scand. 2017 Nov;136(5):378-385. doi: 10.1111/ane.12733. Epub 2017 Jan 30.|
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"I ordered the MediFocus Guidebook on Parkinson's Disease for my father who has had this condition for about 15 years. It was extremely useful to learn about the medications that are used to treat Parkinson's as well as the side-effects. I had read a lot of articles about Parkinson's on the Internet but they were all very general and vague. Your Guidebook provided excellent and comprehensive information from the medical perspective. Thanks for a very useful resource that is much needed today on the Web."
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