| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Lymphocytic Leukemia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Lymphocytic Leukemia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Lymphocytic Leukemia. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Lymphocytic Leukemia every 3 months. Thank you for your ongoing subscription to this publication.
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Elliot Jacob, Ph.D.
Vice-President - Content
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| Authors: | Daniel C, Mato AR |
| Institution: | Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Pennsylvania, Philadelphia, Pennsylvania. | | Journal: | Clin Adv Hematol Oncol. 2017 Mar;15(3):210-218. |
| Authors: | Vangapandu HV, Jain N, Gandhi V |
| Institution: | a Department of Experimental Therapeutics , The University of Texas MD Anderson Cancer Center , Houston , TX , USA. Houston , TX , USA. Cancer Center , Houston , TX , USA. | | Journal: | Expert Opin Investig Drugs. 2017 May;26(5):625-632. doi: 10.1080/13543784.2017.1312338. Epub 2017 Apr 13. |
| Authors: | Itchaki G, Brown JR |
| Institution: | a Department of Medical Oncology , Dana Farber Cancer Institute , Boston , MA , USA. USA. | | Journal: | Expert Opin Investig Drugs. 2017 May;26(5):633-650. doi: 10.1080/13543784.2017.1313230. Epub 2017 Apr 17. |
| Authors: | Molica S |
| Institution: | a Department of Hematology-Oncology , Azienda Ospedaliera Pugliese-Ciaccio , Catanzaro , Italy. | | Journal: | Expert Rev Hematol. 2017 May;10(5):425-432. doi: 10.1080/17474086.2017.1313108. Epub 2017 Apr 12. |
| Authors: | Vitale C, Griggio V, Todaro M, Salvetti C, Boccadoro M, Coscia M |
| Institution: | a Division of Hematology , University of Torino, AOU Citta della Salute e della Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. Scienza di Torino , Torino , Italy. Torino , Torino , Italy. | | Journal: | Expert Opin Pharmacother. 2017 Mar;18(4):411-425. doi: 10.1080/14656566.2017.1293655. Epub 2017 Feb 22. |
| Authors: | Sawas A, Farber CM, Schreeder MT, Khalil MY, Mahadevan D, Deng C, Amengual JE, Nikolinakos PG, Kolesar JM, Kuhn JG, Sportelli P, Miskin HP, O'Connor OA |
| Institution: | Center for Lymphoid Malignancies, Columbia University Medical Center, New York, NY, USA. NY, USA. NY, USA. NY, USA. | | Journal: | Br J Haematol. 2017 Apr;177(2):243-253. doi: 10.1111/bjh.14534. Epub 2017 Feb 21. |
| Authors: | Al-Sawaf O, Fischer K, Engelke A, Pflug N, Hallek M, Goede V |
| Institution: | German CLL Study Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany. Cologne, Cologne, Germany. | | Journal: | Drug Des Devel Ther. 2017 Jan 25;11:295-304. doi: 10.2147/DDDT.S104869. eCollection 2017. |
| Authors: | Aghebati-Maleki L, Shabani M, Baradaran B, Motallebnezhad M, Majidi J, Yousefi M |
| Institution: | Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Medical Sciences, Tehran, Iran. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: jmajidiz@yahoo.com. Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefime@tbzmed.ac.ir. | | Journal: | Biomed Pharmacother. 2017 Apr;88:814-822. doi: 10.1016/j.biopha.2017.01.070. Epub 2017 Feb 1. |
| Authors: | Ogawa Y, Izutsu K, Kiguchi T, Choi I, Takatsuka Y, Ando K, Suzumiya J |
| Institution: | Department of Hematology and Oncology, Tokai University Hospital, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. yoshioga@is.icc.u-tokai.ac.jp. of Public School Teachers, Fukuyama, Japan. Fukuoka, Japan. Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. Japan. | | Journal: | Int J Hematol. 2017 May;105(5):631-637. doi: 10.1007/s12185-016-2178-9. Epub 2017 Feb 3. |
| Authors: | Ito S, Fujiwara SI, Mashima K, Umino K, Minakata D, Nakano H, Yamasaki R, Kawasaki Y, Sugimoto M, Ashizawa M, Yamamoto C, Hatano K, Okazuka K, Sato K, Oh I, Ohmine K, Suzuki T, Muroi K, Kanda Y |
| Institution: | Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. ycanda-tky@umin.ac.jp. | | Journal: | Ann Hematol. 2017 May;96(5):719-724. doi: 10.1007/s00277-017-2933-x. Epub 2017 Feb 1. |
| Authors: | Zelenetz AD, Barrientos JC, Brown JR, Coiffier B, Delgado J, Egyed M, Ghia P, Illes A, Jurczak W, Marlton P, Montillo M, Morschhauser F, Pristupa AS, Robak T, Sharman JP, Simpson D, Smolej L, Tausch E, Adewoye AH, Dreiling LK, Kim Y, Stilgenbauer S, Hillmen P |
| Institution: | Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA. Electronic address: zeleneta@mskcc.org. School, Boston, MA, USA. Ospedale San Raffaele and Universita Vita-Salute San Raffaele, Milan, Italy. School of Medicine, Brisbane, Australia. Italy. France. Hospital, Lodz, Poland. Eugene, OR, USA. University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic. | | Journal: | Lancet Oncol. 2017 Mar;18(3):297-311. doi: 10.1016/S1470-2045(16)30671-4. Epub 2017 Jan 28. |
| Authors: | Ishizawa K, Fukuhara N, Nakaseko C, Chiba S, Ogura M, Okamoto A, Sunaga Y, Tobinai K |
| Institution: | Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi kishizaw@med.id.yamagata-u.ac.jp. Medicine, Sendai, Miyagi. Ibaraki. Aichi. | | Journal: | Jpn J Clin Oncol. 2017 Jan;47(1):54-60. doi: 10.1093/jjco/hyw146. Epub 2016 Oct 7. |
| Authors: | Deeks ED |
| Institution: | Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. demail@springer.com. | | Journal: | Drugs. 2017 Feb;77(2):225-236. doi: 10.1007/s40265-017-0695-3. |
| Authors: | Seymour JF, Ma S, Brander DM, Choi MY, Barrientos J, Davids MS, Anderson MA, Beaven AW, Rosen ST, Tam CS, Prine B, Agarwal SK, Munasinghe W, Zhu M, Lash LL, Desai M, Cerri E, Verdugo M, Kim SY, Humerickhouse RA, Gordon GB, Kipps TJ, Roberts AW |
| Institution: | Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Victorian Comprehensive Cancer Centre, Parkville, Melbourne, VIC, Australia; Faculty of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia. Electronic address: john.seymour@petermac.org. School of Medicine, Chicago, IL, USA. Parkville, Melbourne, VIC, Australia; Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia. Cancer Centre, Parkville, Melbourne, VIC, Australia; Faculty of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia. Faculty of Medicine, University of Melbourne, Parkville, Melbourne, VIC, Australia; Department of Clinical Haematology and BMT, The Royal Melbourne Hospital, Parkville, Melbourne, VIC, Australia; Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia. | | Journal: | Lancet Oncol. 2017 Feb;18(2):230-240. doi: 10.1016/S1470-2045(17)30012-8. Epub 2017 Jan 13. |
| Authors: | Robak T, Stilgenbauer S, Tedeschi A |
| Institution: | Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, 93-510 Lodz, ul. Ciolkowskiego 2, Poland. Electronic address: robaktad@csk.umed.lodz.pl. Ulm 89081, Germany. Electronic address: Stephan.Stilgenbauer@uniklinik-ulm.de. Ospedale Maggiore 3, 20162 Milano, Italy. Electronic address: alessandra.tedeschi@ospedaleniguarda.it. | | Journal: | Cancer Treat Rev. 2017 Feb;53:70-78. doi: 10.1016/j.ctrv.2016.12.007. Epub 2016 Dec 30. |
| Authors: | Varghese AM, Howard DR, Pocock C, Rawstron AC, Follows G, McCarthy H, Dearden C, Fegan C, Milligan D, Smith AF, Gregory W, Hillmen P |
| Institution: | Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK. | | Journal: | Br J Haematol. 2017 Feb;176(4):573-582. doi: 10.1111/bjh.14342. Epub 2016 Dec 29. |
| Authors: | Sharman JP, Farber CM, Mahadevan D, Schreeder MT, Brooks HD, Kolibaba KS, Fanning S, Klein L, Greenwald DR, Sportelli P, Miskin HP, Weiss MS, Burke JM |
| Institution: | Willamette Valley Cancer Institute, Springfield, OR, USA. USA. | | Journal: | Br J Haematol. 2017 Feb;176(3):412-420. doi: 10.1111/bjh.14447. Epub 2016 Dec 16. |
| Authors: | Robak T, Hellmann A, Kloczko J, Loscertales J, Lech-Maranda E, Pagel JM, Mato A, Byrd JC, Awan FT, Hebart H, Garcia-Marco JA, Hill BT, Hallek M, Eisenfeld AJ, Stromatt SC, Jaeger U |
| Institution: | Department of Haematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland. Warsaw, Poland. Medical Education, Warsaw, Poland. USA. Philadelphia, PA, USA. Mutlangen, Germany. Cleveland Clinic, Cleveland, OH, USA. of Excellence on Cellular Stress Responses in Aging (CECAD) University of Cologne, Cologne, Germany. University of Vienna, Vienna, Austria. | | Journal: | Br J Haematol. 2017 Feb;176(4):618-628. doi: 10.1111/bjh.14464. Epub 2016 Dec 15. |
| Authors: | Algrin C, Golmard JL, Michallet M, Reman O, Huynh A, Perrot A, Sirvent A, Plesa A, Salaun V, Bene MC, Bories D, Tournilhac O, Merle-Beral H, Leblond V, Le Garff-Tavernier M, Dhedin N |
| Institution: | Hematologie, Groupe Hospitalier Pitie-Salpetriere, Paris, France. France. France. France. | | Journal: | Eur J Haematol. 2017 Apr;98(4):363-370. doi: 10.1111/ejh.12836. Epub 2017 Jan 30. |
| Authors: | Tees MT, Flinn IW |
| Institution: | a Colorado Blood Cancer Institute , Denver , CO , USA. | | Journal: | Expert Rev Hematol. 2017 Feb;10(2):137-146. doi: 10.1080/17474086.2017.1270203. Epub 2016 Dec 26. |
| Authors: | Korycka-Wolowiec A, Wolowiec D, Robak T |
| Institution: | a Department of Hematology Medical , University of Lodz , Lodz , Poland. | | Journal: | Expert Opin Drug Saf. 2017 Feb;16(2):185-201. doi: 10.1080/14740338.2017.1264387. Epub 2016 Dec 4. |
| Authors: | Al-Sawaf O, Fischer K, Herling CD, Ritgen M, Bottcher S, Bahlo J, Elter T, Stilgenbauer S, Eichhorst BF, Busch R, Elberskirch U, Abenhardt W, Kneba M, Hallek M, Wendtner CM |
| Institution: | Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. Germany. Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. Germany. German CLL Study group, University of Cologne, Cologne, Germany. Germany. German CLL Study group, University of Cologne, Cologne, Germany. German CLL Study group, University of Cologne, Cologne, Germany. Diseases and Tropical Medicine, Klinikum Schwabing, Munich, Germany. | | Journal: | Eur J Haematol. 2017 Mar;98(3):254-262. doi: 10.1111/ejh.12825. Epub 2016 Dec 1. |
| Authors: | Wanquet A, Birsen R, Bonnet C, Boubaya M, Choquet S, Dupuis J, Lepretre S, Re D, Fahri J, Michallet AS, Ysebaert L, Lemal R, Lamy T, Delarue R, Troussard X, Cymbalista F, Levy V, Dietrich PY, Leblond V, Aurran-Schleinitz T |
| Institution: | Department of Haematology, Institut Paoli-Calmettes, Marseille, France. France. Clermont-Ferrand, Clermont-Ferrand, France. | | Journal: | Br J Haematol. 2017 Jan;176(1):37-49. doi: 10.1111/bjh.14387. Epub 2016 Nov 11. |
| Authors: | Roberts AW, Huang D |
| Institution: | Integrated Department of Clinical Hematology, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Australia. Research, Parkville, Australia. Parkville, Australia. Research, Parkville, Australia. Parkville, Australia. | | Journal: | Clin Pharmacol Ther. 2017 Jan;101(1):89-98. doi: 10.1002/cpt.553. Epub 2016 Nov 26. |
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What Our Customers Are Saying... "I was recently diagnosed with CLL and searched all over the Web for information. I found the MediFocus Guidebook on Chronic Lymphocytic Leukemia to be a very useful resource. The information about chemotherapy was most important to me as well as recent studies concerning general treatments for this condition. The most valuable information was contained in the extensive references listed which were easy to access with a simple 'mouse' click. You are welcome to use my name as a reference."
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