| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Lymphocytic Leukemia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Lymphocytic Leukemia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Lymphocytic Leukemia. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Lymphocytic Leukemia every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Buccheri V, Barreto WG, Fogliatto LM, Capra M, Marchiani M, Rocha V |
| Institution: | Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo/ICESP, Av. Dr. Eneas de Carvalho Aguiar, 155, 1 andar, Cerqueira Cesar, Sao Paulo, 05403-000, Brazil. vbbuccheri@gmail.com. Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Brazil. Paulo, Brazil. | | Journal: | Ann Hematol. 2018 Dec;97(12):2269-2278. doi: 10.1007/s00277-018-3503-6. Epub 2018 Oct 12. |
| Authors: | Jain N, Thompson P, Ferrajoli A, Nabhan C, Mato AR, O'Brien S |
| Institution: | From the Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX; Cardinal Health Specialty Solutions, Chicago, IL; Chronic Lymphocytic Leukemia Program, Memorial Sloan Kettering Cancer Center, New York, NY; Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA. | | Journal: | Am Soc Clin Oncol Educ Book. 2018 May 23;(38):580-591. doi: 10.1200/EDBK_200691. |
| Authors: | Samples LS, Graf SA |
| Institution: | a Department of Medicine , University of Washington School of Medicine , Seattle , WA , USA. , WA , USA. WA , USA. Care System , Seattle , WA , USA. | | Journal: | Expert Opin Pharmacother. 2018 Oct;19(15):1675-1684. doi: 10.1080/14656566.2018.1524874. Epub 2018 Sep 27. |
| Authors: | Krause G, Hassenruck F, Hallek M |
| Institution: | Department I of Internal Medicine, University of Cologne, Center of Integrated Oncology Koln Bonn, Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany, guenter.krause@uk-koeln.de. | | Journal: | Drug Des Devel Ther. 2018 Aug 21;12:2577-2590. doi: 10.2147/DDDT.S142406. eCollection 2018. |
| Authors: | Egle A, Pleyer L, Melchardt T, Hartmann TN, Greil R |
| Institution: | Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Disease, Rheumatology, Oncologic Center, Laboratory for Immunological and Molecular Cancer Research, Paracelsus Medical University Salzburg, Austria; Salzburg Cancer Research Institute and Cancer Cluster Salzburg, Austria. Electronic address: r.greil@salk.at. | | Journal: | Cancer Treat Rev. 2018 Nov;70:56-66. doi: 10.1016/j.ctrv.2018.08.003. Epub 2018 Aug 10. |
| Authors: | Hilal T, Betcher JA, Leis JF |
| Institution: | Division of Hematology and Medical Oncology, Mayo Clinic, 5881 E. Mayo Blvd, Phoenix, AZ, 85054, USA. Phoenix, AZ, 85054, USA. leis.jose@mayo.edu. | | Journal: | Curr Hematol Malig Rep. 2018 Aug;13(4):237-243. doi: 10.1007/s11899-018-0461-y. |
| Authors: | Joffe E, Goldschmidt N, Bairey O, Fineman R, Ruchlemer R, Rahimi-Levene N, Shvidel L, Greenbaum U, Aviv A, Tadmor T, Braester A, Arad A, Polliack A, Herishanu Y |
| Institution: | Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. | | Journal: | Eur J Haematol. 2018 Sep;101(3):399-406. doi: 10.1111/ejh.13129. Epub 2018 Aug 3. |
| Authors: | Egle A, Steurer M, Melchardt T, Weiss L, Gassner FJ, Zaborsky N, Geisberger R, Catakovic K, Hartmann TN, Pleyer L, Voskova D, Thaler J, Lang A, Girschikofsky M, Petzer A, Greil R |
| Institution: | Department of Internal Medicine III with Hematology and Medical Oncology, Oncologic Center, Paracelsus Medical University Salzburg, Mullner-Hauptstr. 48, 5020, Salzburg, Austria. r.greil@salk.at.; Salzburg Cancer Research Institute - Laboratory of Immunological and Molecular Cancer Research (SCRI-LIMCR) and Cancer Cluster Salzburg (CCS), Salzburg, Austria. r.greil@salk.at.; Division of Hematology and Oncology, Laboratory for Molecular Genetics and Diagnostics, Innsbruck Medical University, Innsbruck, Austria.; Centre for Hematology and Medical Oncology, Kepler University Hospital, Linz, Austria.; Department for Internal Medicine IV, Hospital Wels-Grieskirchen, Wels, Austria. | | Journal: | Ann Hematol. 2018 Oct;97(10):1825-1839. doi: 10.1007/s00277-018-3380-z. Epub 2018 Jun 4. |
| Authors: | Cai Y, Feng L, Wang X |
| Institution: | Department of Hematology, Provincial Hospital Affiliated to Shandong University, No. 324, Jingwu Road, Jinan, Shandong 250021, People's Republic of China. No. 324, Jingwu Road, Jinan, Shandong 250021, People's Republic of China. Electronic address: fenglili1982624@163.com. No. 324, Jingwu Road, Jinan, Shandong 250021, People's Republic of China; Shandong University School of Medicine, Jinan, Shandong 250012, People's Republic of China. Electronic address: xinw@sdu.edu.cn. | | Journal: | Crit Rev Oncol Hematol. 2018 Jun;126:24-31. doi: 10.1016/j.critrevonc.2018.03.022. Epub 2018 Mar 29. |
| Authors: | Boddu P, Jain N |
| Institution: | The University of Texas MD Anderson Cancer Center, Houston, Texas. | | Journal: | Clin Adv Hematol Oncol. 2018 Apr;16(4):279-288. |
| Authors: | Wasik-Szczepanek E, Szymczyk A, Kowal M, Nogalski A, Hus M |
| Institution: | Department of Haematooncology and Bone Marrow Transplantation, Medical University. University. agnieszka.szymczyk.med@wp.pl. University. Lublin, Poland. University. | | Journal: | Ann Agric Environ Med. 2018 Mar 14;25(1):56-59. doi: 10.5604/12321966.1233571. Epub 2017 Feb 11. |
| Authors: | Seymour JF, Kipps TJ, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Gerecitano J, Robak T, De la Serna J, Jaeger U, Cartron G, Montillo M, Humerickhouse R, Punnoose EA, Li Y, Boyer M, Humphrey K, Mobasher M, Kater AP |
| Institution: | From the Peter MacCallum Cancer Centre, Royal Melbourne Hospital, and University of Melbourne, Melbourne, VIC (J.F.S.), and the John Curtin School of Medical Research, Australian National University, Canberra, ACT (J.D.) - all in Australia; the University of California School of Medicine, San Diego (T.J.K.), and Genentech, South San Francisco (E.A.P., Y.L., M. Mobasher) - both in California; University Hospital Cologne and the Center for Integrated Oncology Cologne-Bonn, Cologne, Germany (B.E.); St. James's University Hospital, Leeds (P.H.), and F. Hoffmann-La Roche, Welwyn Garden City (M.B., K.H.) - both in the United Kingdom; Segal Cancer Center, Lady Davis Institute, Jewish General Hospital, Montreal (S.A.), and the Departments of Medicine and Oncology, University of Calgary, Calgary, AB (C.O.) - all in Canada; Memorial Sloan Kettering Cancer Center, New York (J.G.); the Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland (T.R.); Hospital Universitario 12 de Octubre, Madrid (J.D.S.); Medical University of Vienna, Department of Medicine I, Division of Hematology and Hemostaseology, Vienna (U.J.); the Department of Hematology, Centre Hospitalier Universitaire Montpellier, Montpellier, France (G.C.); the Department of Onco-Hematology, Division of Hematology, Niguarda Cancer Center, Niguarda Hospital, Milan (M. Montillo); AbbVie, North Chicago, IL (R.H.); and the Department of Hematology, Cancer Center Amsterdam, Academic Medical Center, Amsterdam (A.P.K.). | | Journal: | N Engl J Med. 2018 Mar 22;378(12):1107-1120. doi: 10.1056/NEJMoa1713976. |
| Authors: | Brown JR, Hamadani M, Hayslip J, Janssens A, Wagner-Johnston N, Ottmann O, Arnason J, Tilly H, Millenson M, Offner F, Gabrail NY, Ganguly S, Ailawadhi S, Kasar S, Kater AP, Doorduijn JK, Gao L, Lager JJ, Wu B, Egile C, Kersten MJ |
| Institution: | Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address: Jennifer_brown@dfci.harvard.edu. of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. USA. Cardiff University, Cardiff, UK. Boston, MA, USA. University, Rouen, France. USA. City, KS, USA. Lymphoma and Myeloma Center Amsterdam, Amsterdam, Netherlands. Lymphoma and Myeloma Center Amsterdam, Amsterdam, Netherlands. | | Journal: | Lancet Haematol. 2018 Apr;5(4):e170-e180. doi: 10.1016/S2352-3026(18)30030-9. Epub 2018 Mar 14. |
| Authors: | Boddy CS, Ma S |
| Institution: | Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 303 E Superior Street, Lurie 3-103, Chicago, IL, 60611, USA. Northwestern University Feinberg School of Medicine, 676 N St. Clair Street, Suite 850, Chicago, IL, 60611, USA. shuo-ma@northwestern.edu. | | Journal: | Curr Hematol Malig Rep. 2018 Apr;13(2):69-77. doi: 10.1007/s11899-018-0438-x. |
| Authors: | Mihalyova J, Jelinek T, Growkova K, Hrdinka M, Simicek M, Hajek R |
| Institution: | Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic; Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.; Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic; Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic; Faculty of Science, University of Ostrava, Ostrava, Czech Republic. Electronic address: tomas.jelinek@fno.cz. | | Journal: | Exp Hematol. 2018 May;61:10-25. doi: 10.1016/j.exphem.2018.02.002. Epub 2018 Mar 2. |
| Authors: | Hallek M, Shanafelt TD, Eichhorst B |
| Institution: | Department of Internal Medicine, Center of Integrated Oncology Koln Bonn, University Hospital of Cologne, Cologne, Germany. Electronic address: michael.hallek@uni-koeln.de. University Hospital of Cologne, Cologne, Germany. | | Journal: | Lancet. 2018 Apr 14;391(10129):1524-1537. doi: 10.1016/S0140-6736(18)30422-7. Epub 2018 Feb 21. |
| Authors: | Boddu P, Ferrajoli A |
| Institution: | Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 428, Houston, TX, 77030, USA. aferrajo@mdanderson.org. | | Journal: | Curr Hematol Malig Rep. 2018 Apr;13(2):78-90. doi: 10.1007/s11899-018-0439-9. |
| Authors: | Robak T, Blonski J, Skotnicki AB, Piotrowska M, Wrobel T, Rybka J, Kloczko J, Bolkun L, Budziszewska BK, Walczak U, Uss A, Fidecka M, Smolewski P |
| Institution: | Department of Hematology, Copernicus Memorial Hospital, Medical University of Lodz, Lodz, Poland. Lodz, Lodz, Poland. Wroclaw Medical University, Wroclaw, Poland. Wroclaw Medical University, Wroclaw, Poland. Warsaw, Poland. Warsaw, Poland. University of Lodz, Lodz, Poland. | | Journal: | Eur J Haematol. 2018 May;100(5):465-474. doi: 10.1111/ejh.13042. Epub 2018 Mar 22. |
| Authors: | Hill SL, Davies A |
| Institution: | Medical Oncology, Southampton General Hospital, Southampton, UK. Southampton, UK. | | Journal: | Future Oncol. 2018 Jul;14(17):1691-1699. doi: 10.2217/fon-2017-0574. Epub 2018 Feb 6. |
| Authors: | Reiser M, Dorfel S, Hensel M, Hoesl M, Jordan WO, Koenigsmann M, Meyer D, Reichert D, Schwarzer A, Marquardt M, Kellershohn K, Jentsch-Ullrich K |
| Institution: | Praxis internistischer und onkologischer Hamatologie (PIOH), Cologne, Germany. | | Journal: | Eur J Haematol. 2018 May;100(5):455-464. doi: 10.1111/ejh.13040. Epub 2018 Mar 22. |
| Authors: | Dartigeas C, Van Den Neste E, Leger J, Maisonneuve H, Berthou C, Dilhuydy MS, De Guibert S, Lepretre S, Bene MC, Nguyen-Khac F, Letestu R, Cymbalista F, Rodon P, Aurran-Schleinitz T, Vilque JP, Tournilhac O, Mahe B, Laribi K, Michallet AS, Delmer A, Feugier P, Levy V, Delepine R, Colombat P, Leblond V |
| Institution: | Hematologie et Therapie Cellulaire, Hopital Bretonneau, CHU Tours, Tours, France. Electronic address: c.dartigeas@chu-tours.fr. Belgium. Roche Sur Yon, France. Pessac, France. Normandie, Rouen, France. U1138, Universite Paris 6, Paris, France. Clermont-Ferrand, Clermont-Ferrand, France. Berard, Lyon, France. Champagne-Ardenne, Reims, France. Vandoeuvre-les-Nancy, France. Universite Paris 13, Bobigny, France. Tours, France. | | Journal: | Lancet Haematol. 2018 Feb;5(2):e82-e94. doi: 10.1016/S2352-3026(17)30235-1. Epub 2017 Dec 20. |
| Authors: | Jones JA, Mato AR, Wierda WG, Davids MS, Choi M, Cheson BD, Furman RR, Lamanna N, Barr PM, Zhou L, Chyla B, Salem AH, Verdugo M, Humerickhouse RA, Potluri J, Coutre S, Woyach J, Byrd JC |
| Institution: | The Ohio State University, Columbus, OH, USA. Philadelphia, PA, USA. USA. Pharmacy, Ain Shams University, Cairo, Egypt. USA. address: john.byrd@osumc.edu. | | Journal: | Lancet Oncol. 2018 Jan;19(1):65-75. doi: 10.1016/S1470-2045(17)30909-9. Epub 2017 Dec 12. |
| Authors: | Frustaci AM, Tedeschi A, Deodato M, Mazzucchelli M, Cairoli R, Montillo M |
| Institution: | Dept of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano, Piazza Ospedale Maggiore 3, Milano, Italy. | | Journal: | Future Oncol. 2018 Apr;14(8):681-697. doi: 10.2217/fon-2017-0466. Epub 2017 Dec 15. |
| Authors: | Kharfan-Dabaja MA, Moukalled N, Reljic T, El-Asmar J, Kumar A |
| Institution: | Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, USA; Department of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL, USA. University of Beirut Medical Center, Beirut, Lebanon. Morsani College of Medicine, Tampa, FL, USA. Morsani College of Medicine, Tampa, FL, USA. Electronic address: Akumar1@health.USF.edu. | | Journal: | Hematol Oncol Stem Cell Ther. 2018 Jun;11(2):53-64. doi: 10.1016/j.hemonc.2017.11.001. Epub 2017 Nov 26. |
| Authors: | Thompson PA, Burger JA |
| Institution: | a Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA. Houston , TX , USA. | | Journal: | Expert Opin Investig Drugs. 2018 Jan;27(1):31-42. doi: 10.1080/13543784.2018.1404027. Epub 2017 Nov 15. |
| Authors: | Gomes LC, Ferrao ALM, Evangelista FCG, de Almeida TD, Barbosa RC, Carvalho MDG, de Paula Sabino A |
| Institution: | Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, Universidade Federal de Minas Gerais, Address: 6627, Presidente Antonio Carlos Ave, Pampulha, Zip Code 31270-901, Belo Horizonte, MG, Brazil. Electronic address: adriansabin01@gmail.com.; Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Address: 6627, Presidente Antonio Carlos Ave, Pampulha, Zip Code 31270-901, Belo Horizonte, MG, Brazil. | | Journal: | Biomed Pharmacother. 2018 Jan;97:349-358. doi: 10.1016/j.biopha.2017.10.105. Epub 2017 Nov 6. |
| Authors: | Khan M, Siddiqi R, Thompson PA |
| Institution: | Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX, 77030-4009, USA. Holcombe Blvd, Houston, TX, 77030-4009, USA. pathompson2@mdanderson.org. | | Journal: | Ann Hematol. 2018 Jan;97(1):1-15. doi: 10.1007/s00277-017-3149-9. Epub 2017 Oct 23. |
| Authors: | Lee LJ, Toze CL, Huang SJT, Gillan TL, Connors JM, Sehn LH, Bruyere H, Leitch H, Ramadan KM, Gerrie AS |
| Institution: | a Department of Medicine, Division of Hematology , University of British Columbia , Vancouver , Canada. University of British Columbia , Vancouver , Canada. University of British Columbia , Vancouver , Canada. , St. John's , Canada. Vancouver , Canada. Vancouver , Canada. University of British Columbia , Vancouver , Canada. Vancouver , Canada. Vancouver , Canada. University of British Columbia , Vancouver , Canada. Vancouver , Canada. | | Journal: | Leuk Lymphoma. 2018 Jun;59(6):1356-1363. doi: 10.1080/10428194.2017.1387904. Epub 2017 Oct 16. |
| Authors: | Mescher C, Gilbertson D, Randall NM, Tarchand G, Tomaska J, Baumann Kreuziger L, Morrison VA |
| Institution: | a Division of Hematology, Oncology and Transplant , University of Minnesota , Minneapolis , MN , USA. Minneapolis , MN , USA. Minneapolis , MN , USA. Minneapolis , MN , USA. | | Journal: | Leuk Lymphoma. 2018 Jun;59(6):1348-1355. doi: 10.1080/10428194.2017.1375109. Epub 2017 Sep 14. |
| Authors: | Olin JL, Griffiths CL, Smith MB |
| Institution: | 1 Levine College of Health Sciences, Wingate University School of Pharmacy, Wingate, NC, USA. Wingate, NC, USA. USA. | | Journal: | J Oncol Pharm Pract. 2018 Oct;24(7):517-524. doi: 10.1177/1078155217718383. Epub 2017 Jul 11. |
| Authors: | Wendtner CM, Gregor M |
| Institution: | a Klinikum Schwabing, Department of Internal Medicine I , Academic Teaching Hospital of University of Munich , Munich , Germany. | | Journal: | Leuk Lymphoma. 2018 Feb;59(2):300-310. doi: 10.1080/10428194.2017.1330474. Epub 2017 Jun 1. |
| Authors: | Rafei H, Kharfan-Dabaja MA |
| Institution: | Department of Internal Medicine, George Washington University School of Medicine, Washington, DC, USA. Research Institute, Tampa, FL, USA; Department of Oncologic Sciences, College of Medicine, University of South Florida Morsani, Tampa, FL, USA. Electronic address: Mohamed.Kharfan-Dabaja@Moffitt.org. | | Journal: | Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):1-12. doi: 10.1016/j.hemonc.2017.04.002. Epub 2017 May 19. |
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What Our Customers Are Saying... "I was recently diagnosed with CLL and searched all over the Web for information. I found the MediFocus Guidebook on Chronic Lymphocytic Leukemia to be a very useful resource. The information about chemotherapy was most important to me as well as recent studies concerning general treatments for this condition. The most valuable information was contained in the extensive references listed which were easy to access with a simple 'mouse' click. You are welcome to use my name as a reference."
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