Chronic Pancreatitis
February 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Chronic Pancreatitis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Chronic Pancreatitis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Chronic Pancreatitis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Chronic Pancreatitis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Chronic Pancreatitis Finding by Endoscopic Ultrasonography in the Pancreatic Parenchyma of Intraductal Papillary Mucinous Neoplasms Is Associated with Invasive Intraductal Papillary Mucinous Carcinoma.
Authors:Takenaka M, Masuda A, Shiomi H, Yagi Y, Zen Y, Sakai A, Kobayashi T, Arisaka Y, Okabe Y, Kutsumi H, Toyama H, Fukumoto T, Ku Y, Kudo M, Azuma T
Institution:Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Journal:Oncology. 2017;93 Suppl 1:61-68. doi: 10.1159/000481232. Epub 2017 Dec 20.

2:Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts.
Authors:Beyer G, Mahajan UM, Budde C, Bulla TJ, Kohlmann T, Kuhlmann L, Schutte K, Aghdassi AA, Weber E, Weiss FU, Drewes AM, Olesen SS, Lerch MM, Mayerle J
Institution:Department of Medicine A, Universitatsmedizin Greifswald, Ernst-Moritz-Arndt-University Greifswald, Germany; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany. Electronic address:; Department of Medicine A, Universitatsmedizin Greifswald, Ernst-Moritz-Arndt-University Greifswald, Germany.; Institut fur Community Medicine, Universitatsmedizin Greifswald, Ernst-Moritz-Arndt-Universitat Greifswald, Germany.; Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany.
Journal:Gastroenterology. 2017 Dec;153(6):1544-1554.e2. doi: 10.1053/j.gastro.2017.08.073. Epub 2017 Sep 14.

3:Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
Authors:Campa D, Pastore M, Capurso G, Hackert T, Di Leo M, Izbicki JR, Khaw KT, Gioffreda D, Kupcinskas J, Pasquali C, Macinga P, Kaaks R, Stigliano S, Peeters PH, Key TJ, Talar-Wojnarowska R, Vodicka P, Valente R, Vashist YK, Salvia R, Papaconstantinou I, Shimizu Y, Valsuani C, Zambon CF, Gazouli M, Valantiene I, Niesen W, Mohelnikova-Duchonova B, Hara K, Soucek P, Malecka-Panas E, Bueno-de-Mesquita HBA, Johnson T, Brenner H, Tavano F, Fogar P, Ito H, Sperti C, Butterbach K, Latiano A, Andriulli A, Cavestro GM, Busch ORC, Dijk F, Greenhalf W, Matsuo K, Lombardo C, Strobel O, Konig AK, Cuk K, Strothmann H, Katzke V, Cantore M, Mambrini A, Oliverius M, Pezzilli R, Landi S, Canzian F
Institution:Department of Biology, University of Pisa, Pisa, Italy.; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Digestive and Liver Disease Unit, S. Andrea Hospital 'Sapienza' University of Rome, Rome, Italy.; Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany.; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.
Journal:Int J Cancer. 2018 Jan 15;142(2):290-296. doi: 10.1002/ijc.31047. Epub 2017 Oct 16.

4:Frey's procedure for chronic pancreatitis improves the nutritional status of these patients.
Authors:Sato H, Ishida M, Motoi F, Sakata N, Aoki T, Kudoh K, Ohtsuka H, Mizuma M, Morikawa T, Hayashi H, Nakagawa K, Naitoh T, Egawa S, Unno M
Institution:Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.; Division of International Cooperation for Disaster Medicine, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
Journal:Surg Today. 2018 Jan;48(1):80-86. doi: 10.1007/s00595-017-1557-z. Epub 2017 Jun 20.

5:Short- and long-term outcomes of the Frey procedure for chronic pancreatitis: a single-center experience and summary of outcomes in Japan.
Authors:Suzumura K, Hatano E, Okada T, Asano Y, Uyama N, Nakamura I, Hai S, Fujimoto J
Institution:Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Journal:Surg Today. 2018 Jan;48(1):58-65. doi: 10.1007/s00595-017-1548-0. Epub 2017 Jun 8.

6:Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management.
Authors:Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T
Institution:Hospital for Sick Children, Toronto, Ontario, Canada. Massachusetts, USA. Massachusetts, USA. Los Angeles, Los Angeles, California, USA. University of New South Wales and Sydney Children's Hospital Randwick, Sydney, New South Wales, Australia.
Journal:Am J Gastroenterol. 2017 Oct;112(10):1604-1611. doi: 10.1038/ajg.2017.85. Epub 2017 Apr 4.

7:Salvage Islet Auto Transplantation After Relaparatomy.
Authors:Balzano G, Nano R, Maffi P, Mercalli A, Melzi R, Aleotti F, Gavazzi F, Berra C, De Cobelli F, Venturini M, Magistretti P, Scavini M, Capretti G, Del Maschio A, Secchi A, Zerbi A, Falconi M, Piemonti L
Institution:1 Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan, Italy. 2 Diabetes Research Institute; IRCCS San Raffaele Scientific Institute, Milan, Italy. 3 Clinical Transplant Unit, Division of Immunology, Transplantation and Infectious Diseases; IRCCS San Raffaele Scientific Institute, Milan, Italy. 4 Humanitas Clinical and Research Center, Pancreatic Surgery, Rozzano, Italy. 5 Humanitas Clinical and Research Center, Diabetology, Rozzano, Italy. 6 Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy. 7 Vita-Salute San Raffaele University, Milan, Italy. 8 Humanitas University, Department of Biomedical Sciences, Rozzano, Italy.
Journal:Transplantation. 2017 Oct;101(10):2492-2500. doi: 10.1097/TP.0000000000001750.

8:Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis.
Authors:Mayerle J, Kalthoff H, Reszka R, Kamlage B, Peter E, Schniewind B, Gonzalez Maldonado S, Pilarsky C, Heidecke CD, Schatz P, Distler M, Scheiber JA, Mahajan UM, Weiss FU, Grutzmann R, Lerch MM
Institution:Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.; Medizinische Klinik und Poliklinik II, Klinikum der LMU Munchen-Grosshadern, Munchen, Germany.; Section for Molecular Oncology, Institut for Experimental Cancer Research (IET), UKSH, Kiel, Germany.; Metanomics Health GmbH, Berlin, Germany.; metanomics GmbH, Berlin, Germany.
Journal:Gut. 2018 Jan;67(1):128-137. doi: 10.1136/gutjnl-2016-312432. Epub 2017 Jan 20.

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