Atrial Fibrillation
January 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Rhythm control in atrial fibrillation.
Authors:Piccini JP, Fauchier L
Institution:Duke Center for Atrial Fibrillation, Clinical Cardiac Electrophysiology, Duke University Medical Center, Durham, NC, USA. Electronic address:
Journal:Lancet. 2016 Aug 20;388(10046):829-40. doi: 10.1016/S0140-6736(16)31277-6.

2:Rate control in atrial fibrillation.
Authors:Van Gelder IC, Rienstra M, Crijns HJ, Olshansky B
Institution:Department of Cardiology, Thoraxcenter, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. Electronic address: Medical Center Groningen, Groningen, Netherlands. Maastricht (CARIM), Maastricht, Netherlands. IA, USA.
Journal:Lancet. 2016 Aug 20;388(10046):818-28. doi: 10.1016/S0140-6736(16)31258-2.

3:Stroke prevention in atrial fibrillation.
Authors:Freedman B, Potpara TS, Lip GY
Institution:Heart Research Institute, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia; Department of Cardiology and Anzac Research Institute, Concord Hospital, Concord, NSW, Australia. Electronic address: Belgrade, Belgrade, Serbia. Birmingham, UK; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Journal:Lancet. 2016 Aug 20;388(10046):806-17. doi: 10.1016/S0140-6736(16)31257-0.

4:Pulmonary Vein Antrum Isolation in Patients With Paroxysmal Atrial Fibrillation: More Than a Decade of Follow-Up.
Authors:Gokoglan Y, Mohanty S, Gunes MF, Trivedi C, Santangeli P, Gianni C, Asfour IK, Bai R, Burkhardt JD, Horton R, Sanchez J, Hao S, Hongo R, Beheiry S, Di Biase L, Natale A
Institution:For the author affiliations, please see the Appendix section.
Journal:Circ Arrhythm Electrophysiol. 2016 May;9(5). pii: e003660. doi: 10.1161/CIRCEP.115.003660.

5:Multielectrode Pulmonary Vein Isolation Versus Single Tip Wide Area Catheter Ablation for Paroxysmal Atrial Fibrillation: A Multinational Multicenter Randomized Clinical Trial.
Authors:Boersma LV, van der Voort P, Debruyne P, Dekker L, Simmers T, Rossenbacker T, Balt J, Wijffels M, Degreef Y
Institution:From the Cardiology Department, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands (L.V.B., J.B., M.W.); Cardiology Department, Catharina Ziekenhuis, Eindhoven, The Netherlands (P.v.d.V., L.D., T.S.); Cardiology Department, Imelda Ziekenhuis, Bonheiden, Belgium (P.D., T.R.); and Cardiology Department, AZ Middelheim, Antwerpen, Belgium (Y.D.).
Journal:Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003151. doi: 10.1161/CIRCEP.115.003151.

6:Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.
Authors:Magnani JW, Wang N, Benjamin EJ, Garcia ME, Bauer DC, Butler J, Ellinor PT, Kritchevsky S, Marcus GM, Newman A, Phillips CL, Sasai H, Satterfield S, Sullivan LM, Harris TB
Institution:From the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Journal:Circ Arrhythm Electrophysiol. 2016 May;9(5):e003525. doi: 10.1161/CIRCEP.115.003525.

7:Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery.
Authors:Gillinov AM, Bagiella E, Moskowitz AJ, Raiten JM, Groh MA, Bowdish ME, Ailawadi G, Kirkwood KA, Perrault LP, Parides MK, Smith RL 2nd, Kern JA, Dussault G, Hackmann AE, Jeffries NO, Miller MA, Taddei-Peters WC, Rose EA, Weisel RD, Williams DL, Mangusan RF, Argenziano M, Moquete EG, O'Sullivan KL, Pellerin M, Shah KJ, Gammie JS, Mayer ML, Voisine P, Gelijns AC, O'Gara PT, Mack MJ
Institution:From the Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland (A.M.G.); the International Center for Health Outcomes and Innovation Research, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai (E.B., A.J.M., K.A.K., M.K.P., D.L.W., E.G.M., K.L.O., K.J.S., A.C.G.), Department of Cardiac Surgery, Mount Sinai Health System (E.A.R.), and Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians and Surgeons, Columbia University (M.A.) - all in New York; Department of Anesthesiology and Critical Care, University of Pennsylvania (J.M.R.), and Department of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine (M.L.M.) - both in Philadelphia; Cardiovascular and Thoracic Surgery, Mission Health and Hospitals, Asheville, NC (M.A.G., R.F.M.); Department of Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles (M.E.B., A.E.H.); Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Charlottesville (G.A., J.A.K.); Montreal Heart Institute, Universite de Montreal, Montreal (L.P.P., M.P.), Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Hopital Laval, Quebec, QC (G.D., P.V.), and Peter Munk Cardiac Centre and Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network and the Division of Cardiac Surgery, University of Toronto, Toronto (R.D.W.) - all in Canada; Department of Cardiovascular Surgery, Heart Hospital Baylor Plano, Baylor Health Care System, Plano, TX (R.L.S., M.J.M.); Office of Biostatistics Research (N.O.J.) and Division of Cardiovascular Sciences (M.A.M., W.C.T.-P.), National Heart, Lung, and Blood Institute, Bethesda, and Department of Surgery, University of Maryland Medical Center, Baltimore (J.S.G.) - both in Maryland; and the Cardiovascular Division, Brigham and Women's Hospital, Boston (P.T.O.).
Journal:N Engl J Med. 2016 May 19;374(20):1911-21. doi: 10.1056/NEJMoa1602002. Epub 2016 Apr 4.

8:Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation.
Authors:Kuck KH, Brugada J, Furnkranz A, Metzner A, Ouyang F, Chun KR, Elvan A, Arentz T, Bestehorn K, Pocock SJ, Albenque JP, Tondo C
Institution:From the Department of Cardiology, Asklepios Klinik St. Georg, Hamburg (K.-H.K., A.M., F.O.), Cardioangiologisches Centrum Bethanien, Medical Department III am Markus Krankenhaus, Frankfurt (A.F., J.C.), Herz-Zentrum, Bad Krozingen (T.A.), and Technische Universitat Dresden, Dresden (K.B.) - all in Germany; Hospital Clinic, University of Barcelona, Barcelona (J.B.); Isala Klinieken, Zwolle, the Netherlands (A.E.); London School of Hygiene and Tropical Medicine, London (S.J.P.); Clinique Pasteur, Toulouse, France (J.-P.A.); and Centro Cardiologico Monzino, University of Milan, Milan (C.T.).
Journal:N Engl J Med. 2016 Jun 9;374(23):2235-45. doi: 10.1056/NEJMoa1602014. Epub 2016 Apr 4.

9:Atrial fibrillation and silent stroke: links, risks, and challenges.
Authors:Hahne K, Monnig G, Samol A
Institution:Division of Cardiology, University Hospital Munster, Munster, Germany. Hospital Munster, Munster, Germany.
Journal:Vasc Health Risk Manag. 2016 Mar 7;12:65-74. doi: 10.2147/VHRM.S81807. eCollection 2016.

10:Digoxin Use and Adverse Outcomes in Patients With Atrial Fibrillation.
Authors:Zeng WT, Liu ZH, Li ZY, Zhang M, Cheng YJ
Institution:From the Department of Cardiology (W-TZ, Y-JC), the Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Emergency (Z-HL), the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Obstetrics and Gynecology (Z-YL), the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; Department of Cardiology (MZ), Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Journal:Medicine (Baltimore). 2016 Mar;95(12):e2949. doi: 10.1097/MD.0000000000002949.

11:A tailored treatment strategy: a modern approach for stroke prevention in patients with atrial fibrillation.
Authors:Lip GY, Potpara T, Boriani G, Blomstrom-Lundqvist C
Institution:University of Birmingham Institute of Cardiovascular Sciences, Birmingham, UK. University, Aalborg, Denmark. Belgrade, Belgrade, Serbia. Medicine, University of Bologna, S.Orsola-Malpighi University Hospital, Bologna, Italy. Uppsala, Sweden.
Journal:J Intern Med. 2016 May;279(5):467-76. doi: 10.1111/joim.12468. Epub 2016 Mar 22.

12:Shensongyangxin Capsules for Paroxysmal Atrial Fibrillation: A Systematic Review of Randomized Clinical Trials.
Authors:Chen G, Wei B, Wang J, Feng B, Li Z, Zhang Z, He Q
Institution:Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing, 100053, China.; Beijing University of Chinese Medicine, Beijing, 100029, China.; Hubei University of Chinese Medicine, Hubei, 430065, China.
Journal:PLoS One. 2016 Mar 21;11(3):e0151880. doi: 10.1371/journal.pone.0151880. eCollection 2016.

13:The atrial fibrillation conundrum in dialysis patients.
Authors:De Vriese AS, Caluwe R, Raggi P
Institution:Division of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge, Brugge, Belgium. Electronic address: Institute, University of Alberta, Edmonton, Alberta, Canada.
Journal:Am Heart J. 2016 Apr;174:111-9. doi: 10.1016/j.ahj.2016.01.010. Epub 2016 Jan 23.

14:Racial/ethnic differences in atrial fibrillation symptoms, treatment patterns, and outcomes: Insights from Outcomes Registry for Better Informed Treatment for Atrial Fibrillation Registry.
Authors:Golwala H, Jackson LR 2nd, Simon DN, Piccini JP, Gersh B, Go AS, Hylek EM, Kowey PR, Mahaffey KW, Thomas L, Fonarow GC, Peterson ED, Thomas KL
Institution:University of Louisville School of Medicine, Louisville, KY.
Journal:Am Heart J. 2016 Apr;174:29-36. doi: 10.1016/j.ahj.2015.10.028. Epub 2015 Dec 30.

15:The totally thoracoscopic left atrial maze procedure for the treatment of atrial fibrillation.
Authors:van Laar C, Geuzebroek GS, Hofman FN, Van Putte BP
Institution:Department of Cardio-Thoracic Surgery, St Antonius Hospital, Nieuwegein, Netherlands Netherlands. Netherlands. Netherlands.
Journal:Multimed Man Cardiothorac Surg. 2016 Mar 17;2016. pii: mmv043. doi: 10.1093/mmcts/mmv043. Print 2016.

16:Tailored treatment strategies: a new approach for modern management of atrial fibrillation.
Authors:Van Gelder IC, Hobbelt AH, Marcos EG, Schotten U, Cappato R, Lewalter T, Schwieler J, Rienstra M, Boriani G
Institution:Department of Cardiology, Thoraxcenter, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Medical Center Groningen, Groningen, The Netherlands. Medical Center Groningen, Groningen, The Netherlands. Maastricht Centre for Systems Biology, Maastricht, The Netherlands. Munich, Hospital Munich-Thalkirchen, Munich, Germany. Stockholm, Sweden. Medical Center Groningen, Groningen, The Netherlands. Medicine, University of Bologna, S.Orsola-Malpighi University Hospital, Bologna, Italy.
Journal:J Intern Med. 2016 May;279(5):457-66. doi: 10.1111/joim.12489. Epub 2016 Mar 16.

17:Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF.
Authors:Pokorney SD, Piccini JP, Stevens SR, Patel MR, Pieper KS, Halperin JL, Breithardt G, Singer DE, Hankey GJ, Hacke W, Becker RC, Berkowitz SD, Nessel CC, Mahaffey KW, Fox KA, Califf RM
Institution:Duke Clinical Research Institute, Duke University Medical Center, Durham, NC the University of Munster, Germany. Hospital, and Harvard Medical School, Boston, MA. NJ. NC.
Journal:J Am Heart Assoc. 2016 Mar 8;5(3):e002197. doi: 10.1161/JAHA.115.002197.

18:What have we learned of ablation procedures for atrial fibrillation?
Authors:Maurer T, Lundqvist CB, Tilz R, Mont L, Chierchia GB, Malmborg H, Metzner A, Kuck KH
Institution:Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany. Uppsala, Sweden. Germany. Catalonia, Spain. Uppsala, Sweden.
Journal:J Intern Med. 2016 May;279(5):439-48. doi: 10.1111/joim.12488. Epub 2016 Mar 4.

19:Gender Differences of Thromboembolic Events in Atrial Fibrillation.
Authors:Cheng EY, Kong MH
Institution:Silicon Valley Cardiology, E. Palo Alto, California.
Journal:Am J Cardiol. 2016 Mar 15;117(6):1021-7. doi: 10.1016/j.amjcard.2015.12.040. Epub 2015 Dec 31.

20:Individualized approaches to thromboprophylaxis in atrial fibrillation.
Authors:Ziff OJ, Camm AJ
Institution:The Hatter Cardiovascular Institute, University College London, London, United Kingdom. United Kingdom; ICMS, Imperial College, London, United Kingdom. Electronic address:
Journal:Am Heart J. 2016 Mar;173:143-58. doi: 10.1016/j.ahj.2015.10.021. Epub 2015 Nov 11.

21:Body mass index and the risk of new-onset atrial fibrillation in middle-aged adults.
Authors:Berkovitch A, Kivity S, Klempfner R, Segev S, Milwidsky A, Erez A, Sabbag A, Goldenberg I, Sidi Y, Maor E
Institution:Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel; Department of Internal Medicine D, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Department of Internal Medicine C, Chaim Sheba Medical Center, Tel Hashomer, Israel; Pinchas Borenstein Talpiot Medical Leadership Program, Chaim Sheba Medical Center, Tel Hashomer, Israel; Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel.; Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Institute for Medical Screening, Chaim Sheba Medical Center, Tel Hashomer, Israel.; Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Department of Internal Medicine 'E,' Tel-Aviv Medical Center, Tel Aviv, Israel.
Journal:Am Heart J. 2016 Mar;173:41-8. doi: 10.1016/j.ahj.2015.11.016. Epub 2015 Dec 18.

22:Management of postoperative atrial fibrillation after cardiac surgery.
Authors:Ha AC, Mazer CD, Verma S, Yanagawa B, Verma A
Institution:aPeter Munk Cardiac Centre, University Health Network bDepartment of Medicine, University of Toronto cDepartment of Anesthesia, University of Toronto dLi Ka Shing Knowledge Institute, St Michael's Hospital eDepartment of Surgery, University of Toronto fDivision of Cardiac Surgery, St Michael's Hospital, Toronto gDivision of Cardiology, Southlake Regional Health Centre, Newmarket, Canada.
Journal:Curr Opin Cardiol. 2016 Mar;31(2):183-90. doi: 10.1097/HCO.0000000000000264.

23:Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants Compared With Uninterrupted Vitamin K Antagonists in Patients Undergoing Catheter Ablation for Atrial Fibrillation.
Authors:Wu S, Yang YM, Zhu J, Wan HB, Wang J, Zhang H, Shao XH
Institution:Emergency and Intensive Care Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:
Journal:Am J Cardiol. 2016 Mar 15;117(6):926-34. doi: 10.1016/j.amjcard.2015.12.027. Epub 2015 Dec 30.

24:Totally thoracoscopic left atrial Maze: standardized, effective and safe.
Authors:Geuzebroek GS, Bentala M, Molhoek SG, Kelder JC, Schaap J, Van Putte BP
Institution:Department of Cardio-Thoracic Surgery, St Antonius Hospital, Nieuwegein, Netherlands Netherlands. Netherlands Department of Cardio-Thoracic Surgery, Amphia Hospital, Breda, Netherlands.
Journal:Interact Cardiovasc Thorac Surg. 2016 Mar;22(3):259-64. doi: 10.1093/icvts/ivv358. Epub 2015 Dec 23.

25:Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment.
Authors:Fabritz L, Guasch E, Antoniades C, Bardinet I, Benninger G, Betts TR, Brand E, Breithardt G, Bucklar-Suchankova G, Camm AJ, Cartlidge D, Casadei B, Chua WW, Crijns HJ, Deeks J, Hatem S, Hidden-Lucet F, Kaab S, Maniadakis N, Martin S, Mont L, Reinecke H, Sinner MF, Schotten U, Southwood T, Stoll M, Vardas P, Wakili R, West A, Ziegler A, Kirchhof P
Institution:Institute of Cardiovascular Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.; Department of Cardiovascular Medicine, Division of Rhythmology, University Hospital Munster, Schlossplatz 2, 48149 Munich, Germany.; Hospital Clinic de Barcelona, Villarroel, 170, 08036 Barcelona, Spain.; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Carrer del Rossello, 149, 08036 Barcelona, Spain.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Journal:Nat Rev Cardiol. 2016 Apr;13(4):230-7. doi: 10.1038/nrcardio.2015.194. Epub 2015 Dec 24.

26:Long-Term Follow-Up of Cardiac Rhythm in 320 Patients After the Cox-Maze III Procedure for Atrial Fibrillation.
Authors:Albage A, Johansson B, Kenneback G, Kallner G, Schersten H, Jideus L
Institution:Department of Cardiothoracic Surgery, University Hospital, Uppsala, Sweden. Electronic address: Gothenburg, Sweden. Sweden. Hospital/Sahlgrenska, Gothenburg, Sweden.
Journal:Ann Thorac Surg. 2016 Apr;101(4):1443-9. doi: 10.1016/j.athoracsur.2015.09.066. Epub 2015 Dec 2.

27:Long Term Follow-up of Pulmonary Vein Isolation Using Cryoballoon Ablation.
Authors:Davies AJ, Jackson N, Barlow M, Leitch J
Institution:Cardiovascular Department, John Hunter Hospital, Newcastle, NSW, Australia. Electronic address:
Journal:Heart Lung Circ. 2016 Mar;25(3):290-5. doi: 10.1016/j.hlc.2015.07.012. Epub 2015 Aug 3.

28:Anticoagulation in atrial fibrillation and chronic heart failure: the risk and drug of choice.
Authors:Boos CJ, Brown L
Institution:aDepartment of Cardiology, Poole Hospital NHS Foundation Trust, Poole bDepartment of Postgraduate Medical Education, Bournemouth University, Bournemouth, UK.
Journal:Curr Opin Cardiol. 2016 Mar;31(2):229-34. doi: 10.1097/HCO.0000000000000245.

29:The Risk Stratification and Stroke Prevention Therapy Care Gap in Canadian Atrial Fibrillation Patients.
Authors:Angaran P, Dorian P, Tan MK, Kerr CR, Green MS, Gladstone DJ, Mitchell LB, Fournier C, Cox JL, Talajic M, Lin PJ, Langer A, Goldin L, Goodman SG
Institution:Terrence Donnelly Heart Centre, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Toronto, Ontario, Canada. Canada. University of Toronto, Toronto, Ontario, Canada. University of Calgary and Alberta Health Services, Calgary, Alberta, Canada. Scotia, Canada. Toronto, Ontario, Canada. Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada. Electronic address:
Journal:Can J Cardiol. 2016 Mar;32(3):336-43. doi: 10.1016/j.cjca.2015.07.012. Epub 2015 Oct 15.

30:Oral Anticoagulation and the Risk of Stroke or Death in Patients With Atrial Fibrillation and One Additional Stroke Risk Factor: The Loire Valley Atrial Fibrillation Project.
Authors:Fauchier L, Lecoq C, Clementy N, Bernard A, Angoulvant D, Ivanes F, Babuty D, Lip GY
Institution:Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Faculte de Medecine, Universite Francois Rabelais, Tours, France. Electronic address:; University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Journal:Chest. 2016 Apr;149(4):960-8. doi: 10.1378/chest.15-1622. Epub 2016 Jan 12.

31:Stroke, Major Bleeding, and Mortality Outcomes in Warfarin Users With Atrial Fibrillation and Chronic Kidney Disease: A Meta-Analysis of Observational Studies.
Authors:Dahal K, Kunwar S, Rijal J, Schulman P, Lee J
Institution:Department of Medicine, LRGHealthcare, University of New England, Laconia, NH. University, Providence, RI. Farmington, CT. Farmington, CT. Electronic address:
Journal:Chest. 2016 Apr;149(4):951-9. doi: 10.1378/chest.15-1719. Epub 2016 Jan 12.

32:Amiodarone after surgical ablation for atrial fibrillation: Is it really necessary? A prospective randomized controlled trial.
Authors:Ad N, Holmes SD, Shuman DJ, Pritchard G, Miller CE
Institution:Cardiac Surgery Research, Inova Heart and Vascular Institute, Falls Church, Va. Electronic address:
Journal:J Thorac Cardiovasc Surg. 2016 Mar;151(3):798-803. doi: 10.1016/j.jtcvs.2015.07.034. Epub 2015 Jul 17.

33:Long-term events following atrial fibrillation rate control or transcatheter ablation: a multicenter observational study.
Authors:Gallo C, Battaglia A, Anselmino M, Bianchi F, Grossi S, Nangeroni G, Toso E, Gaido L, Scaglione M, Ferraris F, Gaita F
Institution:aDivision of Cardiology, Department of Medical Sciences, Citta della Salute e della Scienza, University of Turin, TurinbDivision of Cardiology, Department of Internal Medicine, Cardinal Massaia Hospital, AsticDivision of Cardiology, Mauriziano Umberto I Hospital, Turin, Italy.
Journal:J Cardiovasc Med (Hagerstown). 2016 Mar;17(3):187-93. doi: 10.2459/JCM.0000000000000311.

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