Atrial Fibrillation
August 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).
Authors:Steinberg BA, Shrader P, Thomas L, Ansell J, Fonarow GC, Gersh BJ, Hylek E, Kowey PR, Mahaffey KW, O'Brien EC, Singer DE, Peterson ED, Piccini JP
Institution:Division of Cardiovascular Medicine, University of Utah Health Sciences Center, Salt Lake City, UT; Duke University Medical Center, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address: benjamin.steinberg@hsc.utah.edu. ansellje@gmail.com. GFonarow@mednet.ucla.edu. Elaine.Hylek@bmc.org. KoweyP@mlhs.org. Kenneth.mahaffey@stanford.edu. address: desinger@partners.org. Durham, NC. Durham, NC.
Journal:Am Heart J. 2017 Jul;189:40-47. doi: 10.1016/j.ahj.2017.03.024. Epub 2017 Apr 4.

2:Non-Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction.
Authors:Yao X, Shah ND, Sangaralingham LR, Gersh BJ, Noseworthy PA
Institution:Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Electronic address: yao.xiaoxi@mayo.edu. Mayo Clinic, Rochester, Minnesota; Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; OptumLabs, Cambridge, Massachusetts. Mayo Clinic, Rochester, Minnesota. Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
Journal:J Am Coll Cardiol. 2017 Jun 13;69(23):2779-2790. doi: 10.1016/j.jacc.2017.03.600.

3:Atrial fibrillation incrementally increases dementia risk across all CHADS2 and CHA2DS2VASc strata in patients receiving long-term warfarin.
Authors:Graves KG, May HT, Jacobs V, Bair TL, Stevens SM, Woller SC, Crandall BG, Cutler MJ, Day JD, Mallender C, Osborn JS, Peter Weiss J, Jared Bunch T
Institution:Intermountain Medical Center Heart Institute, Intermountain Medical Center, Murray, UT.; Intermountain Medical Center Heart Institute, Intermountain Medical Center, Murray, UT; Stanford University, Department of Internal Medicine, Palo Alto, CA. Electronic address: Thomas.bunch@imail.org.
Journal:Am Heart J. 2017 Jun;188:93-98. doi: 10.1016/j.ahj.2017.02.026. Epub 2017 Feb 24.

4:Chocolate intake and risk of clinically apparent atrial fibrillation: the Danish Diet, Cancer, and Health Study.
Authors:Mostofsky E, Berg Johansen M, Tjonneland A, Chahal HS, Mittleman MA, Overvad K
Institution:Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Massachusetts, USA. Dentistry, Western University, London, Ontario, Canada. Boston, Massachusetts, USA. Massachusetts, USA. Denmark.
Journal:Heart. 2017 Aug;103(15):1163-1167. doi: 10.1136/heartjnl-2016-310357. Epub 2017 May 23.

5:Initiation of anticoagulation in atrial fibrillation: which factors are associated with choice of anticoagulant?
Authors:Gundlund A, Staerk L, Fosbol EL, Gadsboll K, Sindet-Pedersen C, Bonde AN, Gislason GH, Olesen JB
Institution:Department of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark. Copenhagen, Denmark. Denmark.
Journal:J Intern Med. 2017 Aug;282(2):164-174. doi: 10.1111/joim.12628. Epub 2017 May 30.

6:Factors associated with rhythm control treatment decisions in patients with atrial fibrillation-Insights from the NCDR PINNACLE registry.
Authors:Gehi AK, Doros G, Glorioso TJ, Grunwald GK, Hsu J, Song Y, Turakhia MP, Turchin A, Virani SS, Maddox TM
Institution:Section of Cardiac Electrophysiology, Division of Cardiology, University of North Carolina, Chapel Hill, NC. Electronic address: anilgehi@med.unc.edu.; Harvard Clinical Research Institute, Boston, MA; Department of Biostatistics, Boston University, Boston, MA.; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver Anschutz Medical Campus, Aurora, CO; VA Eastern Colorado Health Care System, University of Colorado School of Medicine, and the Colorado Cardiovascular Outcomes Research Consortium, Denver, CO.; Section of Cardiac Electrophysiology, Division of Cardiology, University of California San Diego, La Jolla, CA.; Harvard Clinical Research Institute, Boston, MA.
Journal:Am Heart J. 2017 May;187:88-97. doi: 10.1016/j.ahj.2017.02.006. Epub 2017 Feb 16.

7:Management of Major Bleeding in Patients With Atrial Fibrillation Treated With Non-Vitamin K Antagonist Oral Anticoagulants Compared With Warfarin in Clinical Practice (from Phase II of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF II]).
Authors:Steinberg BA, Simon DN, Thomas L, Ansell J, Fonarow GC, Gersh BJ, Kowey PR, Mahaffey KW, Peterson ED, Piccini JP
Institution:Division of Cardiovascular Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah; Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina. Electronic address: benjamin.steinberg@hsc.utah.edu. California. California. Duke Clinical Research Institute, Durham, North Carolina. Duke Clinical Research Institute, Durham, North Carolina.
Journal:Am J Cardiol. 2017 May 15;119(10):1590-1595. doi: 10.1016/j.amjcard.2017.02.015. Epub 2017 Mar 28.

8:Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation.
Authors:Schnabel RB, Pecen L, Ojeda FM, Lucerna M, Rzayeva N, Blankenberg S, Darius H, Kotecha D, Caterina R, Kirchhof P
Institution:Department of Cardiology, University Heart Center Hamburg-Eppendorf, German Center for Cardiovascular Research (DZHK) partner site Hamburg/Kiel/Lubeck, Hamburg, Germany.; Medical Facility Pilsen of Charles University, Pilsen, Czech Republic.; Daiichi Sankyo Europe GmbH, Munich, Germany.; Department of Cardiology, Angiology, Nephrology and Conservative Intensive Care Medicine, Vivantes Klinikum Neukolln, Berlin, Germany.; School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, UK.
Journal:Heart. 2017 Jul;103(13):1024-1030. doi: 10.1136/heartjnl-2016-310406. Epub 2017 Feb 22.

9:Effects of dabigatran according to age in atrial fibrillation.
Authors:Lauw MN, Eikelboom JW, Coppens M, Wallentin L, Yusuf S, Ezekowitz M, Oldgren J, Nakamya J, Wang J, Connolly SJ
Institution:McMaster University and Hamilton Health Sciences, Population Health Research Institute, Hamilton, Ontario, Canada. Netherlands. Institute, Hamilton, Ontario, Canada. Institute, Hamilton, Ontario, Canada. Netherlands. Uppsala, Sweden. Institute, Hamilton, Ontario, Canada. Pennsylvania, USA. Uppsala, Sweden. Institute, Hamilton, Ontario, Canada. Institute, Hamilton, Ontario, Canada. Institute, Hamilton, Ontario, Canada.
Journal:Heart. 2017 Jul;103(13):1015-1023. doi: 10.1136/heartjnl-2016-310358. Epub 2017 Feb 17.

10:Management of Major Bleeding Events in Patients Treated With Dabigatran for Nonvalvular Atrial Fibrillation: A Retrospective, Multicenter Review.
Authors:Milling TJ, Fromm C, Ganetsky M, Pallin DJ, Cong J, Singer AJ
Institution:Seton Dell Medical School Stroke Institute, Austin, TX. Electronic address: tmilling@seton.org. Medical School, Boston, MA. NY.
Journal:Ann Emerg Med. 2017 May;69(5):531-540. doi: 10.1016/j.annemergmed.2016.11.040. Epub 2017 Feb 10.

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