Medifocus Guidebook on Polycystic Kidney Disease

A Comprehensive Patient Guide to Symptoms, Treatment, Research, and Support
 

 
Updated: January 30, 2017
137 Pages

 
 

What is Polycystic Kidney Disease?

According to the American Kidney Foundation, polycystic kidney disease (PKD) is the most common life threatening genetic disorder caused by a single gene and affects between 1 in 400 to 1,000 people worldwide. It is characterized by fluid-filled cysts that form in the nephrons of both kidneys (bilateral) and eventually lead to kidney failure in the majority of patients. Polycystic kidney disease is the fourth most common cause of kidney failure.

Cysts usually begin as an outpouching (like a blister) anywhere along the length of the nephrons. Approximately 70% of the cysts detach from the nephron when they are small and proceed to enlarge as they fill with either clear fluid or fluid that may contain blood cells. In patients with PKD, hundreds to thousands of cysts can develop that range from the size of a pinhead to as large as a grapefruit (10-20 cm.) in diameter. Each kidney may expand to as large as a football and may weigh up to 38 pounds. The continual enlargement of cysts crowds out healthy kidney tissue. The kidneys may quadruple in size before kidney function is affected at which point renal function rapidly declines.

In addition, normal tissue can be actively destroyed and fibrous tissue can form resulting in a condition called interstitial fibrosis. The combination of cysts and progressive interstitial fibrosis is thought to accelerate chronic renal failure, resulting in the kidney's loss of ability to cleanse the blood and concentrate urine.

There are at least three factors related to cyst formation in the kidney but exactly what triggers the process is unclear. These three factors include:

  • Increased production of cells lining the cyst wall. These cells continue to reproduce throughout life and enable the cyst to enlarge.
  • Increased production of fluid by the cells forming the cyst.
  • Abnormal basement membrane structure and function. The basement membrane is a thin layer of tissue upon which the cysts rest. In PKD the makeup of the basement membrane is abnormal, the tissue is also thicker than usual, and attachment to the cyst wall is increased.

Hypertension (high blood pressure) is closely associated with PKD due to the increased burden placed on the blood vessels from inadequately filtered blood. It is often one of the earliest symptoms of PKD and develops in most patients by the age of 20 or 30.

Polycystic kidney disease (PKD) affects approximately 600,000-700,000 people in the United States. Approximately 12.5 million people worldwide are believed to suffer from PKD. It is also thought to account for 7-10% of people who are on dialysis and require mechanical filtration of blood.

Additional important facts about PKD include:

  • Approximately 5,000 to 6,000 new cases of PKD are diagnosed each year in the U.S.
  • 40% of the cases diagnosed yearly in the U.S. are people of age 45 or less.
  • 5-10% of people with PKD have no known familial history of PKD.
  • Approximately 50% of patients diagnosed with autosomal dominant polycystic kidney disease (ADPKD) progress to end-stage renal disease by the age of 60.
  • Polycystic kidney disease is considered to be the fourth leading cause of kidney failure and appears to affect all races and genders equally.

Knowledge is Critical when Dealing with a Life-Altering Condition such as Polycystic Kidney Disease

If you or a loved one has been diagnosed with PKD, it's critical to learn everything you possibly can about this condition so that you can make informed decisions about your treatment. That's why we created the Medifocus Guidebook on Polycystic Kidney Disease, a comprehensive 137 page patient Guidebook that contains vital information about PKD that you won't find anywhere in a single source.

The Medifocus Guidebook on Polycystic Kidney Disease starts out with a detailed overview of the condition and quickly imparts fundamentally important information about PKD, including:

  • A detailed overview of the major types of PKD which include:

    • Autosomal-dominant PKD
    • Autosomal-recessive PKD
    • Acquired cystic kidney disease
  • The underlying causes of PKD including the role of genetic, cellular, and hormonal factors in the disease process.

  • The risk factors that are associated with a more rapid decline in kidney function in people who suffer from PKD.
  • The secondary complications that can develop as a consequence of PKD, including:

    • High blood pressure
    • Acute and chronic pain
    • Extrarenal cysts - cysts that develop outside the kidneys
    • Intracranial aneurysms - a bulging of the wall of a blood vessel in the brain that can lead to a stroke
    • End-stage kidney disease
  • The predominant signs and symptoms of PKD.

  • How PKD is diagnosed based on factors such as signs/symptoms, patient history, physical examination, imaging studies, and genetic testing.

Understanding the Standard Treatments... and the Treatment Options

The goals of treatment for patients with PKD include:

  • Managing and better controlling the symptoms of the disease.
  • Preventing progression of the disease to end-stage kidney disease.
  • Enabling the patient to maintain a reasonably good quality of life.
  • Prolonging survival

Understanding the standard treatments - and the treatment options - is critical for successfully achieving the goals of treatment for patients with PKD. As you read through the section of the Guidebook that focuses on the treatments for PKD, you will specifically learn about:

  • The treatment options that are available to manage specific symptoms and secondary complications of PKD, including:

    • Pain management strategies
    • Strategies for lowering and better controlling high blood pressure
    • Management of urinary tract infections in people with PKD
    • Management of kidney stones in people with PKD
  • The treatment options that are available for the management of patients with PKD who develop end-stage kidney disease, including:

    • Peritoneal dialysis
    • Hemodialysis
    • Kidney transplantation
  • The management of PKD during pregnancy.

  • The role of nutrition and lifestyle modifications in the management of people with PKD.
  • The prognosis (outlook) for people with PKD and the important factors that can have a significant impact in predicting the overall chances of recovery and survival.
  • Quality of life issues that confront people with PKD and how to minimize their impact on activities of daily living and cope better with these issues.
  • Important questions to ask your doctor about PKD.

A "One-of-a-Kind" Reference Guidebook on Polycystic Kidney Disease that Goes Way Beyond the Fundamentals

Since 1996, when Medifocus was founded, we've learned that many people with Polycystic Kidney Disease are seeking more specific information that goes beyond the fundamentals, such as the causes, diagnosis, standard treatments, and treatment options. That's why we developed a "one-of-a-kind" reference Guidebook that goes way beyond the basics and also includes the following sections:

  • A Guide to Recent Medical Literature on Polycystic Kidney Disease - This section of the Guidebook contains an extensive bibliography of over 100 references to recently published articles about Polycystic Kidney Disease in authoritative, peer-reviewed medical journals with links to the absracts (summaries) of the articles. These articles represent the latest advances in the field and focus on cutting-edge research, new developments, and the lessons learned from recently published clinical trials involving patients with Polycystic Kidney Disease. This is the same level of that is used by doctors who treat people with Polycystic Kidney Disease to keep abreast of the latest developments and breakthroughs in this specialized field of medicine.

  • Centers of Research for Polycystic Kidney Disease - We've compiled a unique directory of doctors, hospitals, medical centers, and research institutions with special interest and, in many cases, clinical expertise in managing people with Polycystic Kidney Disease. The "Centers of Research" directory is a valuable resource for quickly identifying and locating leading medical authorities and medical institutions both within the United States and other countries who are considered to be at the forefront in clinical research and treatment of Polycystic Kidney Disease. You'd have to spend days - or even weeks - attempting to compile your own list of doctors and medical centers but, with the "Centers of Research" directory, the information is already right at your fingertips. All you have to do is act on the information by selecting and contacting the experts or medical institutions listed in the directory by state and country.

  • Organizations and Support Groups for Polycystic Kidney Disease - The Guidebook also includes a directory of organizations and support groups whose goal is to help people with Polycystic Kidney Disease by providing access to information, resources, and services. Many of these organizations can answer your specific questions, enable you to "network" with other patients, and provide guidance in areas such as financial, social, or medical-legal issues. This valuable directory of organizations and support groups includes complete contact information, including phone numbers and E-mail addresses.

Look Inside the Guidebook

The Guidebook is a Value-Added Proposition that Comes with a Risk-Free Satisfaction Guarantee so that...You have Nothing to Lose and Everything to Gain

Still not sure if you'll benefit from the Medifocus Guidebook on Polycystic Kidney Disease? Still not convinced that the information included in the Guidebook is worth the minimal cost? If that's the case, then please consider the following value-added proposition that comes standard with your purchase of the Guidebook:

  • Free Updates for One Year - With your initial purchase of the Guidebook, you also receive access to free updates for one-full year. The Guidebook is updated with new information every 4 to 6 months, so that you will be able to access the updated information several times during the course of a year for up to one full year after the date of your initial purchase.

  • Free Digest E-Mail Alerts - When you purchase the Guidebook, you will also automatically receive a free subscription to our monthly newsletter - the Medifocus Digest Alert for Polycystic Kidney Disease. This is an expertly selected listing of the latest articles published in the medical literature about Polycystic Kidney Disease with convenient links to the abstracts of the articles that focus on cutting-edge research, clinical trials, and the latest treatment advances. The Medifocus Digest Alert for Polycystic Kidney Disease is automatically delivered straight to your "inbox" monthly and is a valuable resource for keeping up with the latest developments in Polycystic Kidney Disease almost as soon as the new information is published in the medical literature.

  • 20% Discount - For a limited time, you can purchase the Medifocus Guidebook on Polycystic Kidney Disease at a special 20% discount off the regular list price. Your 20% discount will automatically be applied when you go to "Checkout".

  • Risk-Free Satisfaction Guarantee - Your purchase comes with our RISK-FREE satisfaction guarantee. If, for whatever reason, you are not totally satisfied with the content of your Guidebook, simply contact us within 30-days of your purchase for a prompt, full refund. We are so confident that you will be satisfied with your Guidebook that we offer this RISK-FREE satisfaction guarantee unconditionally - no questions and no hassles.

Order Your Copy of the Medifocus Guidebook on Polycystic Kidney Disease Today!

The Medifocus Guidebook on Polycystic Kidney Disease (137 pages; last updated January 30, 2017) is available in the following two convenient formats:

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Medifocus Guidebook on Polycystic Kidney Disease


Updated: January 30, 2017
137 Pages

This one of a kind Guidebook offers:

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  • Discounted Price = $22.35
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What Our Customers Are Saying...

"Last year my brother and his daughter were diagnosed with PKD. We had no idea what this disease was, if there was a cure, or how it would affect my family. There seemed to be very little information about PKD. Then I found the MediFocus Guidebook on Polycystic Kidney Disease. What a tremendous help! It has answered many questions and has given us some hope. Thank you."
J.R.
Muskegon, Michigan


"I found the MediFocus Guidebook on Polycystic Kidney Disease to be very informative with links to loads of information. It has been extremely helpful learning about my inherited PKD disease which is very common yet not heard of by the general public."
C.S.
Flint, Michigan


"The Medifocus Guidebook on Polycystic Kidney Disease is great reference material. It's nice to be able to go to one single source for information on PKD. The Guidebook is full of useful information."
R.M.
Denver, Colorado


 
Medifocus Guidebook on Polycystic Kidney Disease

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