Importance of anti-centromere antibodies in the diagnosis of Sjögren's syndrome

J Oral Sci. 2022 Oct 1;64(4):324-326. doi: 10.2334/josnusd.22-0231. Epub 2022 Sep 12.

Abstract

The purpose of the present study was to indicate that patients with anti-centromere antibodies (ACA) also experience ocular/oral dryness like patients with anti-Ro/SSA and/or anti-La/SSB antibodies (anti-SSA/SSB). A total of 80 patients with subjective ocular and/or oral dryness were classified into two groups, namely, anti-SSA/SSB-positive (anti-SSA/SSB [+]) group and ACA-positive (ACA [+]) group. The degree of ocular and oral dryness in ACA (+) patients is similar to that in anti-SSA/SSB (+) patients. On histopathological examination of the labial glands, the area of fibrosis was significantly larger in the ACA (+) group than in the anti-SSA/SSB (+) group. Thus, ACA (+) patients should be examined for Sjögren's syndrome.

Keywords: Sjögren’s syndrome; anti-Ro/SSA and anti-La/SSB antibodies; anti-centromere antibody; collagen fiber; dryness.

MeSH terms

  • Antibodies, Antinuclear
  • Chromosomal Proteins, Non-Histone
  • Humans
  • Sjogren's Syndrome* / diagnosis
  • Xerostomia*

Substances

  • Antibodies, Antinuclear
  • Chromosomal Proteins, Non-Histone
  • centromere protein C