An overview of painful diabetic peripheral neuropathy: Diagnosis and treatment advancements

Jonathan M Hagedorn; Alyson M Engle; Tony K George; Jay Karri; Newaj Abdullah; Erik Ovrom; Jhon E Bocanegra-Becerra; Ryan S D'Souza

doi:10.1016/j.diabres.2022.109928

An overview of painful diabetic peripheral neuropathy: Diagnosis and treatment advancements

Diabetes Res Clin Pract. 2022 Jun:188:109928. doi: 10.1016/j.diabres.2022.109928. Epub 2022 May 14.

Authors

Jonathan M Hagedorn¹, Alyson M Engle², Tony K George³, Jay Karri⁴, Newaj Abdullah⁵, Erik Ovrom⁶, Jhon E Bocanegra-Becerra⁷, Ryan S D'Souza⁸

Affiliations

¹ iSpine Pain Physicians, Maple Grove, MN, USA. Electronic address: jonhagedornmd@yahoo.com.
² Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
³ University Pain Medicine Center, Somerset, NJ, USA.
⁴ Johns Hopkins University, Baltimore, MD, USA.
⁵ Division of Pain Medicine, Department of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
⁶ Mayo Clinic Alix School of Medicine, Rochester, MN, USA.
⁷ Universidad Peruana Cayetano Heredia School of Medicine, Lima, Peru.
⁸ Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA.

PMID: 35580704
DOI: 10.1016/j.diabres.2022.109928

Abstract

Diabetes mellitus remains a public health problem, affecting 422 million people worldwide. Currently, there is no consensus around treating painful diabetic peripheral neuropathy in a step-wise manner. Among the non-pharmacological interventions, neuromodulation has become a promising alternative. Over the past decade, significant clinical trials have paved the way for prompt inclusion of high-frequency spinal cord stimulation within the painful diabetic peripheral neuropathy treatment algorithm. This article aims to provide an updated evidence-based approach for the management of painful diabetic peripheral neuropathy.

Publication types

Review

MeSH terms

Diabetes Mellitus*
Diabetic Neuropathies* / drug therapy
Diabetic Neuropathies* / therapy
Humans
Pain