The neuroprotective roles of Dietary Micronutrients on Parkinson's disease: a review

Mol Biol Rep. 2022 Aug;49(8):8051-8060. doi: 10.1007/s11033-022-07345-w. Epub 2022 May 8.

Abstract

Parkinson's disease (PD) is a prevalent elderly neurodegenerative disease. The nature of PD is strongly bounded with certain cellular processes, including oxidative stress, neuro-inflammation, apoptosis, and mitochondrial dysfunction. Therefore, many clinical and pre-clinical studies have reported protective effects of certain dietary micronutrients for PD. Hence, this review tried to introduce a series of important dietary micronutrients, which to our best of knowledge, were among those compounds known as beneficial for PD with a high consensus. The compounds possess neuroprotective properties (e.g. anti-oxidation, anti-inflammation, anti-apoptosis, boosting mitochondrial performance, regulating autophagy process). Thus, the compounds probably may act on several cellular targets to prevent the development of PD or to attenuate the progress of the disease. Investigating these compounds probably can lead to the development of novel supplementary therapeutic approaches, as well as refinement of dietary regimen of PD patients.

Keywords: Anti-inflammation; Antioxidants; Micronutrients; Oxidative stress; Parkinson’s disease.

Publication types

  • Review

MeSH terms

  • Aged
  • Humans
  • Micronutrients / metabolism
  • Micronutrients / pharmacology
  • Micronutrients / therapeutic use
  • Mitochondria / metabolism
  • Neurodegenerative Diseases* / metabolism
  • Neuroprotective Agents* / metabolism
  • Neuroprotective Agents* / pharmacology
  • Neuroprotective Agents* / therapeutic use
  • Oxidative Stress
  • Parkinson Disease* / drug therapy

Substances

  • Micronutrients
  • Neuroprotective Agents