Is COVID-19 a Perfect Storm for Parkinson's Disease?

Trends Neurosci. 2020 Dec;43(12):931-933. doi: 10.1016/j.tins.2020.10.009. Epub 2020 Oct 21.

Abstract

Three recent case reports (by Méndez-Guerrero et al.,Cohen et al., and Faber et al.) describe the development of acute parkinsonism following coronavirus disease 2019 (COVID-19). We discuss possible underlying cellular and molecular mechanisms, and whether COVID-19 might be associated with elevated long-term risk of Parkinson's disease (PD).

Keywords: SARS-CoV-2; alpha-synuclein; dopamine; neurodegeneration; neuroinflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • COVID-19 / complications*
  • COVID-19 / pathology
  • COVID-19 / physiopathology
  • Humans
  • Parkinson Disease / virology*
  • SARS-CoV-2