The Yin and Yang of myelodysplastic syndromes and autoimmunity: The paradox of autoimmune disorders responding to therapies specific for MDS

Claudio Fozza; Giorgio La Nasa; Giovanni Caocci

doi:10.1016/j.critrevonc.2019.07.018

The Yin and Yang of myelodysplastic syndromes and autoimmunity: The paradox of autoimmune disorders responding to therapies specific for MDS

Crit Rev Oncol Hematol. 2019 Oct:142:51-57. doi: 10.1016/j.critrevonc.2019.07.018. Epub 2019 Jul 26.

Authors

Claudio Fozza¹, Giorgio La Nasa², Giovanni Caocci²

Affiliations

¹ Hematology Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 12, 07100 Sassari, Italy. Electronic address: cfozza@uniss.it.
² Hematology Unit, Department of Medical Sciences, University of Cagliari, Cagliari, Italy.

PMID: 31376677
DOI: 10.1016/j.critrevonc.2019.07.018

Abstract

The biological milieu and clinical picture of myelodysplastic syndromes (MDS) is characterised by a variety of immune mechanisms and manifestations, including an increased frequency of autoimmune disorders. The present review will try to shed some light on the potential clinical and pathogenetic implications of these immune processes in MDS by focusing on the beneficial effects exerted by some MDS-modifying therapies on autoimmune manifestations.

Keywords: Autoimmune manifestations; Autoimmunity; Immunotherapy; Myelodysplastic syndromes.

Publication types

Review

MeSH terms

Autoimmune Diseases / drug therapy
Autoimmune Diseases / therapy*
Autoimmunity*
Humans
Myelodysplastic Syndromes / drug therapy
Myelodysplastic Syndromes / immunology
Myelodysplastic Syndromes / therapy*