The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ: Suggestions for routine practice

Crit Rev Oncol Hematol. 2019 Jun:138:207-213. doi: 10.1016/j.critrevonc.2019.04.016. Epub 2019 Apr 20.

Abstract

Background: Risk factors for local recurrence after mastectomy in ductal carcinoma in situ (DCIS) emerged as a grey area during the second "Assisi Think Tank Meeting" (ATTM) on Breast Cancer.

Aim: To review practice patterns of post-mastectomy radiation therapy (PMRT) in DCIS, identify risk factors for recurrence and select suitable candidates for PMRT.

Methods: A questionnaire concerning DCIS management, focusing on PMRT, was distributed online via SurveyMonkey.

Results: 142 responses were received from 15 countries. The majority worked in academic institutions, had 5-20 years work-experience and irradiated <5 DCIS patients/year. PMRT was more given if: surgical margins <1 mm, high-grade, multicentricity, young age, tumour size >5 cm, skin- or nipple- sparing mastectomy. Moderate hypofractionation was the most common schedule, except after immediate breast reconstruction (57% conventional fractionation).

Conclusions: The present survey highlighted risk factors for PMRT administration, which should be further evaluated.

Keywords: Breast cancer; Ductal carcinoma in situ; Hypofractionation; Post-mastectomy radiotherapy; Survey.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / radiotherapy*
  • Breast Neoplasms / surgery
  • Carcinoma, Intraductal, Noninfiltrating / radiotherapy*
  • Carcinoma, Intraductal, Noninfiltrating / surgery
  • Dose Fractionation, Radiation
  • Female
  • Humans
  • Mastectomy
  • Middle Aged
  • Neoplasm Recurrence, Local / prevention & control
  • Radiation Oncology*
  • Radiotherapy, Adjuvant / methods*
  • Risk Factors
  • Surveys and Questionnaires