Diabetic amyotrophy: a painful radiculoplexus neuropathy

Pract Neurol. 2019 Apr;19(2):164-167. doi: 10.1136/practneurol-2018-002105. Epub 2018 Dec 8.

Abstract

Diabetic lumbosacral radiculoplexus neuropathy is a monophasic syndrome of diffuse pain and weakness that typically affects the lower limbs asymmetrically and is often associated with significant weight loss. Recovery can be prolonged and unpredictable. It is a clinical diagnosis and investigations are performed mainly to exclude other causes. Although it is most likely caused by a microvasculitis, there is no evidence to support using intravenous immunoglobulin or any long-term immunosuppression. Pulsed methylprednisolone may help pain if given within 2-3 months of symptom onset.

Publication types

  • Review

MeSH terms

  • Diabetic Neuropathies / diagnosis
  • Diabetic Neuropathies / therapy*
  • Diagnosis, Differential
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Methylprednisolone / therapeutic use*
  • Pain / diagnosis
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / therapy*
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous
  • Methylprednisolone

Supplementary concepts

  • Neuropathy, Painful