The long-term efficacy of STN vs GPi deep brain stimulation for Parkinson disease: A meta-analysis

Medicine (Baltimore). 2018 Aug;97(35):e12153. doi: 10.1097/MD.0000000000012153.

Abstract

Objective: This meta-analysis assessed the long-term efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus interna (GPi) for Parkinson disease (PD).

Methods: PubMed, Cochrane Library, and Clinical Trials databases were searched. Outcomes were unified Parkinson disease rating scale section (UPDRS) III off-medication score, Parkinson's disease questionnaire: 39 activities of daily living (PDQ-39 ADL) score, and levodopa-equivalent dosage after DBS.

Results: During the off-medication state, pooled weighted mean difference (WMD) of UPDRS III score was .69 (95% confidence interval [CI] = -1.77 to 3.16, P = .58). In subgroup analysis, WMD of UPDRS III off-medication scores from baseline to 2 years and 3 years post-DBS were -.61 (95% CI = -2.97 to 1.75, P = .61) and 2.59 (95% CI = -2.30 to 7.47, P = .30). Pooled WMD of changes in tremor, rigidity, and gait scores were 1.12 (95% CI = -0.05 to 2.28, P = .06), 1.22 (95% CI = -0.51 to 2.94, P = .17) and .37 (95% CI = -0.13 to 0.87, P = .15), respectively. After DBS, pooled WMD of PDQ-39 ADL and LED were -3.36 (95% CI = -6.36 to -0.36, P = .03) and 194.89 (95% CI = 113.16 to 276.63, P < .001).

Conclusions: STN-DBS and GPi-DBS improve motor function and activities of daily living for PD. Differences in the long-term efficacy for PD on motor symptoms were not observed.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Aged
  • Deep Brain Stimulation / statistics & numerical data*
  • Female
  • Gait / physiology
  • Globus Pallidus*
  • Humans
  • Male
  • Middle Aged
  • Muscle Rigidity / etiology
  • Muscle Rigidity / physiopathology
  • Muscle Rigidity / therapy
  • Parkinson Disease / complications
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy*
  • Severity of Illness Index
  • Subthalamic Nucleus*
  • Time
  • Treatment Outcome
  • Tremor / etiology
  • Tremor / physiopathology
  • Tremor / therapy