SnapShot: Chronic Lymphocytic Leukemia

Cancer Cell. 2017 Nov 13;32(5):716-716.e1. doi: 10.1016/j.ccell.2017.10.015.

Abstract

Despite the recent advances in the therapeutic management of Chronic Lymphocytic Leukemia (CLL) patients, this common B cell malignancy still remains incurable. This SnapShot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental interactions, which contribute to disease progression and therapy resistance. To view this SnapShot, open or download the PDF.

MeSH terms

  • B-Lymphocytes / metabolism
  • B-Lymphocytes / pathology
  • Disease Progression
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Leukemia, Lymphocytic, Chronic, B-Cell / therapy
  • Models, Genetic
  • Mutation*
  • Signal Transduction / genetics
  • Tumor Microenvironment / genetics*