Treatment of Glioblastoma

J Oncol Pract. 2017 Oct;13(10):629-638. doi: 10.1200/JOP.2017.025536.

Abstract

Glioblastoma is the most common and most aggressive form of primary brain tumor in adults and contributes to high social and medical burden as a result of its incurable nature and significant neurologic morbidity. Despite ongoing research, there has not been improvement in survival in glioblastoma. This review discusses recent advances in clinically significant molecular profiling, including IDH mutation status and O6-methylguanine-DNA methyltransferase ( MGMT) promoter methylation. We review updates in management of newly diagnosed and recurrent glioblastoma, as well as common difficulties in management, such as pseudoprogression and pseudoresponse. Ongoing translational research in targeted therapy and immunotherapy is briefly discussed.

Publication types

  • Review

MeSH terms

  • Aftercare
  • Age Factors
  • Angiogenesis Inhibitors / therapeutic use*
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Bevacizumab / therapeutic use
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / genetics
  • Brain Neoplasms / therapy*
  • Chemoradiotherapy, Adjuvant
  • Chemotherapy, Adjuvant
  • Cranial Irradiation / methods*
  • Cytoreduction Surgical Procedures
  • DNA Methylation
  • DNA Modification Methylases / genetics
  • DNA Repair Enzymes / genetics
  • Dacarbazine / analogs & derivatives*
  • Dacarbazine / therapeutic use
  • Glioblastoma / diagnostic imaging
  • Glioblastoma / genetics
  • Glioblastoma / therapy*
  • Humans
  • Isocitrate Dehydrogenase / genetics
  • Magnetic Resonance Imaging
  • Mutation
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / therapy*
  • Neurosurgical Procedures / methods*
  • Promoter Regions, Genetic
  • Radiotherapy, Adjuvant
  • Temozolomide
  • Tumor Suppressor Proteins / genetics

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents, Alkylating
  • Tumor Suppressor Proteins
  • Bevacizumab
  • Dacarbazine
  • Isocitrate Dehydrogenase
  • DNA Modification Methylases
  • MGMT protein, human
  • DNA Repair Enzymes
  • Temozolomide