Efficacy of Intratympanic Gentamicin in Menière's Disease With and Without Migraine

Otol Neurotol. 2017 Aug;38(7):1005-1009. doi: 10.1097/MAO.0000000000001460.

Abstract

Objective: To compare the efficacy of intratympanic gentamicin injection (ITG) on vertigo control, drop attacks, and functional level in Menière's disease patients with and without a history of migraine.

Patients: Menière's disease patients (patients with migraine and age- and sex-matched control patients without migraine) treated from 2002 to 2012 who failed medical management and received ITG, with a minimum 2-year follow up.

Intervention: ITG.

Main outcome measures: Vertigo control, drop attack prevalence, and change in functional level.

Results: Twenty-eight Menière's disease patients were included in this study (14 with migraine and 14 matched patients without migraine). There were three men and 11 women in each groups, with a mean age of 53 ± 8.9 years. Baseline characteristics (Menière's stage, vertigo frequency, drop attack prevalence, and functional level) before ITG were not significantly different between the two groups. Two years after ITG, 71% of Menière's disease with migraine patients and 78% of Menière's disease without migraine patients had class A, B, or C vertigo control (p > 0.999). Change in prevalence of drop attacks (43-7% versus 50-0%, respectively) was also similar (p > 0.999). However, significantly fewer vertigo control class A, B, and C migraine patients achieved functional level 1 or 2 (40%) compared with non-migraine patients (91%) (p = 0.007).

Conclusions: Although ITG appears equally effective in treating vertigo and drop attacks in Menière's disease with and without migraine, patients with migraine derive significantly less benefit in terms of functional improvement.

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Female
  • Gentamicins / administration & dosage
  • Gentamicins / therapeutic use*
  • Humans
  • Male
  • Meniere Disease / complications
  • Meniere Disease / drug therapy*
  • Middle Aged
  • Migraine Disorders / complications
  • Migraine Disorders / drug therapy*
  • Syncope / complications
  • Syncope / drug therapy*
  • Treatment Outcome
  • Tympanic Membrane / drug effects*
  • Vertigo / complications
  • Vertigo / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Gentamicins