Potential application of the Kampo medicine goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy

J Integr Med. 2017 Mar;15(2):77-87. doi: 10.1016/S2095-4964(17)60313-3.

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and severe adverse effects related to cancer treatment. Unfortunately, although several agents and protocols have been proposed, no prophylactic strategies have yet to be proven useful. Therefore, new alternative therapies have been considered for CIPN prevention. Herbal medicine in Japan, called Kampo medicine, is derived from traditional Chinese medicine. Goshajinkigan (GJG) is a Kampo medicine, that is comprised of ten herbs. The aim of this work is to analyse the results of pre-clinical and clinical studies on the potential applications of GJG in CIPN prevention.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Drugs, Chinese Herbal / therapeutic use*
  • Humans
  • Medicine, Kampo*
  • Peripheral Nervous System Diseases / chemically induced
  • Peripheral Nervous System Diseases / prevention & control*
  • Phytotherapy*

Substances

  • Antineoplastic Agents
  • Drugs, Chinese Herbal
  • gosha-jinki-gan