Investigating the effects of a multidimensional exercise program on symptoms and antiinflammatory status in female patients with ankylosing spondylitis

Complement Ther Clin Pract. 2016 Feb:22:38-43. doi: 10.1016/j.ctcp.2015.11.002. Epub 2015 Dec 2.

Abstract

Objective: The purpose of this study is to investigate the effects of a multidimensional exercise program on symptoms and antiinflammatory status in female patients with ankylosing spondylitis (AS).

Methods: The BATH Indexes, Dougados Functional Index (DFI), Health Assessment Questionnaire in Spondyloarthopathies (HAQ-S), Ankylosing Spondylitis Quality of Life (ASQoL) and Beck Depression Inventory (BDI) were used to evaluate twenty-four female AS patients. ESR, CRP, TNF-α and IL-6 were also analyzed. All patients were assessed at baseline and with 3 weeks intervals till 12 week. A multidimensional exercise program was applied for three times a week.

Results: There were significant differences in Bath Ankylosing Spondylitis Global Index (BAS-G) and Disease Activity Index (BASDAI), HAQ-S, ASQoL and BDI scores (p < 0.05). The level of the ESR, CRP and IL-6 fluctuated slightly. There was only significant difference at 3 and 12 weeks as compared to baseline levels in TNF-α values (p = 0.048, p < 0.001).

Conclusion: We concluded that multidimensional exercise program should be taken into consideration for AS patients due to its positive effects on symptoms and antiinflammatory effects.

Keywords: Ankylosing spondylitis; Cytokine; Exercise; Inflammation; Multidimensional exercise program.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cytokines / blood
  • Exercise Therapy*
  • Female
  • Humans
  • Inflammation / therapy*
  • Middle Aged
  • Quality of Life
  • Severity of Illness Index
  • Spondylitis, Ankylosing / therapy*

Substances

  • Cytokines