Each month hundreds of thousands of consumers and healthcare professionals search the National Library of Medicine's Medline database seeking the latest information on their disease/condition. Conducting a thorough and effective Medline search is both a time consuming and daunting task. At Medifocus, we have developed an effective solution to this problem: each month our staff of expert researchers searches Medline for the latest advances in research and clinical medicine for over 70 diseases / conditions. We do this with one goal in mind: to empower you to effectively take control over your health.

Here is the result of our team's work in Chronic Obstructive Pulmonary Disease this month:

1:	Chronic obstructive pulmonary disease: diagnosis and management.

Authors:	Kaufman G
Institution:	Department of Health Sciences, University of York, York. gerri.kaufman@york.ac.uk
Journal:	Nurs Stand. 2013 Jan 23-29;27(21):53-7, 60-2.

2:	Roflumilast: doubtful efficacy but clear harms in COPD.

Authors:
Journal:	Prescrire Int. 2013 Jan;22(134):5-9.

3:	Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease.

Authors:	Barnes PJ
Institution:	National Heart and Lung Institute, Imperial College, London, United Kingdom. p.j.barnes@imperial.ac.uk
Journal:	J Allergy Clin Immunol. 2013 Mar;131(3):636-45. doi: 10.1016/j.jaci.2012.12.1564. Epub 2013 Jan 26.

4:	Clinical phenotypes of chronic obstructive pulmonary disease and asthma: recent advances.

Authors:	Carolan BJ, Sutherland ER
Institution:	Department of Medicine, National Jewish Health, Denver, Colo., USA.
Journal:	J Allergy Clin Immunol. 2013 Mar;131(3):627-34; quiz 635. doi: 10.1016/j.jaci.2013.01.010. Epub 2013 Jan 26.

5:	Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION).

Authors:	Mentz RJ, Schulte PJ, Fleg JL, Fiuzat M, Kraus WE, Pina IL, Keteyian SJ, Kitzman DW, Whellan DJ, Ellis SJ, O'Connor CM
Institution:	Duke University Medical Center, Durham, NC, USA. robert.mentz@duke.edu
Journal:	Am Heart J. 2013 Feb;165(2):193-9. doi: 10.1016/j.ahj.2012.10.029. Epub 2012 Nov 28.

6:	50-year trends in smoking-related mortality in the United States.

Authors:	Thun MJ, Carter BD, Feskanich D, Freedman ND, Prentice R, Lopez AD, Hartge P, Gapstur SM
Institution:	Department of Epidemiology, American Cancer Society, Atlanta, GA 30303-1002, USA. michael.thun@cancer.org
Journal:	N Engl J Med. 2013 Jan 24;368(4):351-64. doi: 10.1056/NEJMsa1211127.

7:	COPD exacerbations.

Authors:	Burt L, Corbridge S
Institution:	Department of Biobehavioral Health Science, University of Illinois at Chicago, College of Nursing, USA. leah.callison@gmail.com
Journal:	Am J Nurs. 2013 Feb;113(2):34-43; quiz 44. doi: 10.1097/01.NAJ.0000426688.96330.60.

8:	The influence of cigarette smoking on viral infections: translating bench science to impact COPD pathogenesis and acute exacerbations of COPD clinically.

Authors:	Bauer CM, Morissette MC, Stampfli MR
Institution:	Pharma Research and Early Development, Inflammation Discovery and Translational Area, Hoffmann-La Roche Inc, Nutley, NJ, USA.
Journal:	Chest. 2013 Jan;143(1):196-206. doi: 10.1378/chest.12-0930.

9:	Ambulatory home oxygen: what is the evidence for benefit, and who does it help?

Authors:	Criner GJ
Institution:	Division of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. Gerard.Criner@tuhs.temple.edu
Journal:	Respir Care. 2013 Jan;58(1):48-64. doi: 10.4187/respcare.01918.

10:	Supplemental oxygen needs during sleep. Who benefits?

Authors:	Owens RL
Institution:	Division of Pulmonary and Critical Care Medicine, and the Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. rowens@partners.org
Journal:	Respir Care. 2013 Jan;58(1):32-47. doi: 10.4187/respcare.01988.

11:	Comparative effectiveness of drugs for chronic obstructive pulmonary disease.

Authors:	Cazzola M, Segreti A, Rogliani P
Institution:	Department of System Medicine, University of Rome Tor Vergata, Rome, Italy. mario.cazzola@uniroma2.it
Journal:	Drugs Today (Barc). 2012 Dec;48(12):785-94. doi: 10.1358/dot.2012.48.12.1860770.

12:	Aclidinium bromide for the treatment of chronic obstructive pulmonary disease.

Authors:	Joos GF
Institution:	Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. Guy.Joos@ugent.be
Journal:	Drugs Today (Barc). 2012 Dec;48(12):757-63. doi: 10.1358/dot.2012.48.12.1885871.

13:	Antibiotics for exacerbations of chronic obstructive pulmonary disease.

Authors:	Vollenweider DJ, Jarrett H, Steurer-Stey CA, Garcia-Aymerich J, Puhan MA
Institution:	General Internal Medicine, John Hopkins University, Baltimore, MD, USA.danivollenweider@yahoo.de
Journal:	Cochrane Database Syst Rev. 2012 Dec 12;12:CD010257. doi: 10.1002/14651858.CD010257.

14:	Long-term oxygen therapy: battling breathlessness.

Authors:	Wick JY
Institution:	University of Connecticut School of Pharmacy, Storrs, CT, USA.
Journal:	Consult Pharm. 2012 Dec;27(12):826-30, 833-6. doi: 10.4140/TCP.n.2012.826.

15:	Lung volume reduction surgery 10 years later.

Authors:	Baldi S, Oliaro A, Tabbia G, Bardessono M, Solidoro P, Mancuso M, Sita C, Ruffini E
Institution:	Pulmonary Division, Ospedale S. Giovanni Battista, Turin, Italy. baldi_sergio@hotmail.com
Journal:	J Cardiovasc Surg (Torino). 2012 Dec;53(6):809-15.

16:	Chronic bronchitis and chronic obstructive pulmonary disease.

Authors:	Kim V, Criner GJ
Institution:	Division of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. victor.kim@tuhs.temple.edu
Journal:	Am J Respir Crit Care Med. 2013 Feb 1;187(3):228-37. doi: 10.1164/rccm.201210-1843CI. Epub 2012 Nov 29.

17:	Chronic obstructive pulmonary disease among adults--United States, 2011.

Authors:
Journal:	MMWR Morb Mortal Wkly Rep. 2012 Nov 23;61(46):938-43.

18:	TNFalpha antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial.

Authors:	Aaron SD, Vandemheen KL, Maltais F, Field SK, Sin DD, Bourbeau J, Marciniuk DD, FitzGerald JM, Nair P, Mallick R
Institution:	Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada. saaron@ohri.ca
Journal:	Thorax. 2013 Feb;68(2):142-8. doi: 10.1136/thoraxjnl-2012-202432. Epub 2012 Nov 17.

19:	Novel antiinflammatory therapies for COPD.

Authors:	Gross NJ
Institution:	Pulmonary Division, Department of Medicine, St. Francis Hospital, Hartford, CT 06032, USA. grossnicholas1@gmail.com
Journal:	Chest. 2012 Nov;142(5):1300-7. doi: 10.1378/chest.11-2766.

20:	Nutritional targets to enhance exercise performance in chronic obstructive pulmonary disease.

Authors:	van de Bool C, Steiner MC, Schols AM
Institution:	Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Journal:	Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):553-60. doi: 10.1097/MCO.0b013e328358bdeb.

21:	Short term and long term effects of pulmonary rehabilitation on physical activity in COPD.

Authors:	Egan C, Deering BM, Blake C, Fullen BM, McCormack NM, Spruit MA, Costello RW
Institution:	Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Journal:	Respir Med. 2012 Dec;106(12):1671-9. doi: 10.1016/j.rmed.2012.08.016. Epub 2012 Oct 12.

22:	Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: systematic review and mixed treatment comparison meta-analysis of randomised controlled trials.

Authors:	Dong YH, Lin HH, Shau WY, Wu YC, Chang CH, Lai MS
Institution:	Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Journal:	Thorax. 2013 Jan;68(1):48-56. doi: 10.1136/thoraxjnl-2012-201926. Epub 2012 Oct 6.

23:	Indacaterol therapy in patients with COPD not receiving other maintenance treatment.

Authors:	Decramer M, Rossi A, Lawrence D, McBryan D
Institution:	Respiratory Division, University Hospitals, Chief Respiratory Division UZ Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Marc.Decramer@uzleuven.be
Journal:	Respir Med. 2012 Dec;106(12):1706-14. doi: 10.1016/j.rmed.2012.08.022. Epub 2012 Sep 29.

24:	Care of patients with a diagnosis of chronic obstructive pulmonary disease: a cluster randomised controlled trial.

Authors:	Zwar NA, Hermiz O, Comino E, Middleton S, Vagholkar S, Xuan W, Wilson SF, Marks GB
Institution:	University of New South Wales, Sydney, NSW, Australia. n.zwar@unsw.edu.au
Journal:	Med J Aust. 2012 Oct 1;197(7):394-8.

25:	Walking exercise response to bronchodilation in mild COPD: a randomized trial.

Authors:	Gagnon P, Saey D, Provencher S, Milot J, Bourbeau J, Tan WC, Martel S, Maltais F
Institution:	Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725 Chemin Ste-Foy Quebec, Universite Laval, Quebec G1V 4G5, Canada. philippe.gagnon@criucpq.ulaval.ca
Journal:	Respir Med. 2012 Dec;106(12):1695-705. doi: 10.1016/j.rmed.2012.08.021. Epub 2012 Sep 20.

26:	Association between beta-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension.

Authors:	Stefan MS, Rothberg MB, Priya A, Pekow PS, Au DH, Lindenauer PK
Institution:	Division of General Medicine, Department of Medicine, Baystate Medical Center, Springfield, MA, USA. mihaela.stefan@bhs.org
Journal:	Thorax. 2012 Nov;67(11):977-84. doi: 10.1136/thoraxjnl-2012-201945. Epub 2012 Aug 31.

27:	Risk of new onset diabetes mellitus in patients with asthma or COPD taking inhaled corticosteroids.

Authors:	O'Byrne PM, Rennard S, Gerstein H, Radner F, Peterson S, Lindberg B, Carlsson LG, Sin DD
Institution:	Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. obyrnep@mcmaster.ca
Journal:	Respir Med. 2012 Nov;106(11):1487-93. doi: 10.1016/j.rmed.2012.07.011. Epub 2012 Aug 15.

28:	Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.

Authors:	Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R
Institution:	Manchester Academic Sciences Health Centre, Respiratory Research Group, University of Manchester, University Hospital South Manchester, Southmoor Road, Manchester M23 9LT, UK. jorgen.vestbo@manchester.ac.uk
Journal:	Am J Respir Crit Care Med. 2013 Feb 15;187(4):347-65. doi: 10.1164/rccm.201204-0596PP. Epub 2012 Aug 9.

29:	Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients.

Authors:	Mroz RM, Minarowski L, Chyczewska E
Institution:	Department of Lung Diseases, Medical University of Bialystok, Zurawia 14, Bialystok, Poland. robmroz@wp.pl
Journal:	Adv Exp Med Biol. 2013;756:23-8. doi: 10.1007/978-94-007-4549-0_4.

30:	Effectiveness of low-intensity aquatic exercise on COPD: a randomized clinical trial.

Authors:	de Souto Araujo ZT, de Miranda Silva Nogueira PA, Cabral EE, de Paula Dos Santos L, da Silva IS, Ferreira GM
Institution:	Coordination of Physiotherapy, Integrated College Patos, Av. Pombal, 630, 58030-241 Joao Pessoa, Brazil.
Journal:	Respir Med. 2012 Nov;106(11):1535-43. doi: 10.1016/j.rmed.2012.06.022. Epub 2012 Jul 17.

31:	Association between antibiotic treatment and outcomes in patients hospitalized with acute exacerbation of COPD treated with systemic steroids.

Authors:	Stefan MS, Rothberg MB, Shieh MS, Pekow PS, Lindenauer PK
Institution:	Division of General Medicine, Department of Medicine, Baystate Medical Center, Springfield, MA 01199, USA. mihaela.stefan@bhs.org
Journal:	Chest. 2013 Jan;143(1):82-90.

32:	Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD.

Authors:	Georgiopoulou VV, Dimopoulos S, Sakellariou D, Papazachou O, Gerovasili V, Tasoulis A, Agapitou V, Vogiatzis I, Roussos C, Nanas S
Institution:	First Critical Care Medicine Department, National and Kapodistrian University of Athens, Greece.
Journal:	Respir Care. 2012 Dec;57(12):2095-103. doi: 10.4187/respcare.01485.

33:	Relation between COPD severity and global cardiovascular risk in US adults.

Authors:	Lee HM, Lee J, Lee K, Luo Y, Sin DD, Wong ND
Institution:	Heart Disease Prevention Program, Divisionof Cardiology, School of Medicine, University of California, Irvine, CA 92697-4101, USA. leehwamumd@gmail.com
Journal:	Chest. 2012 Nov;142(5):1118-25.

34:	Comparison of indacaterol with tiotropium or twice-daily long-acting beta -agonists for stable COPD: a systematic review.

Authors:	Rodrigo GJ, Neffen H
Institution:	Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, 11300 Uruguay. gustavo.javier.rodrigo@gmail.com
Journal:	Chest. 2012 Nov;142(5):1104-10.

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