Each month hundreds of thousands of consumers and healthcare professionals search the National Library of Medicine's Medline database seeking the latest information on their disease/condition. Conducting a thorough and effective Medline search is both a time consuming and daunting task. At Medifocus, we have developed an effective solution to this problem: each month our staff of expert researchers searches Medline for the latest advances in research and clinical medicine for over 70 diseases / conditions. We do this with one goal in mind: to empower you to effectively take control over your health.

Here is the result of our team's work in Renal Cell Carcinoma this month:

1:	Resistance to targeted therapy in renal-cell carcinoma.

Authors:	Rini BI, Atkins MB
Institution:	Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Glickman Urologic and Kidney Institute, 9500 Euclid Avenue/Desk R35, Cleveland, OH 44195, USA. rinib2@ccf.org
Journal:	Lancet Oncol. 2009 Oct;10(10):992-1000.

2:	Computed tomography in metastatic renal cell carcinoma.

Authors:	Griffin N, Grant LA, Bharwani N, Sohaib SA
Institution:	Department of Radiology, Guy's and St. Thomas' Hospital, London, UK. nyree.griffin@gstt.nhs.uk
Journal:	Semin Ultrasound CT MR. 2009 Aug;30(4):359-66.

3:	Management of small renal masses.

Authors:	Kunkle DA, Kutikov A, Uzzo RG
Institution:	Carolina Urological Associates, Winston-Salem, NC 27103, USA. dakunkle@yahoo.com
Journal:	Semin Ultrasound CT MR. 2009 Aug;30(4):352-8.

4:	Phase II study of sunitinib administered in a continuous once-daily dosing regimen in patients with cytokine-refractory metastatic renal cell carcinoma.

Authors:	Escudier B, Roigas J, Gillessen S, Harmenberg U, Srinivas S, Mulder SF, Fountzilas G, Peschel C, Flodgren P, Maneval EC, Chen I, Vogelzang NJ
Institution:	Unite Immunotherapie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France. bernard.escudier@igr.fr
Journal:	J Clin Oncol. 2009 Sep 1;27(25):4068-75. Epub 2009 Aug 3.

5:	Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma.

Authors:	Jonasch E, Wood CG, Matin SF, Tu SM, Pagliaro LC, Corn PG, Aparicio A, Tamboli P, Millikan RE, Wang X, Araujo JC, Arap W, Tannir N
Institution:	Department ofGenitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, PO Box 301439, Houston, TX 77230-1439, USA. ejonasch@mdanderson.org
Journal:	J Clin Oncol. 2009 Sep 1;27(25):4076-81. Epub 2009 Jul 27.

6:	A population-based analysis of the rate of cytoreductive nephrectomy for metastatic renal cell carcinoma in the United States.

Authors:	Jeldres C, Baillargeon-Gagne S, Liberman D, Isbarn H, Capitanio U, Shariat SF, Sun M, Lughezzani G, Perrotte P, Montorsi F, Graefen M, Karakiewicz PI
Institution:	Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada.
Journal:	Urology. 2009 Oct;74(4):837-41. Epub 2009 Jul 18.

7:	Patient and pathologic correlates with perioperative and long-term outcomes of laparoscopic radical nephrectomy.

Authors:	Gabr AH, Gdor Y, Strope SA, Roberts WW, Wolf JS Jr
Institution:	Department of Urology, University of Michigan Health System, Ann Arbor, Michigan 48109-0330, USA.
Journal:	Urology. 2009 Sep;74(3):635-40. Epub 2009 Jul 18.

8:	Surgical resection of renal cell carcinoma after targeted therapy.

Authors:	Thomas AA, Rini BI, Stephenson AJ, Garcia JA, Fergany A, Krishnamurthi V, Novick AC, Gill IS, Klein EA, Zhou M, Campbell SC
Institution:	Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA.
Journal:	J Urol. 2009 Sep;182(3):881-6. Epub 2009 Jul 17.

9:	Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial.

Authors:	Gore ME, Szczylik C, Porta C, Bracarda S, Bjarnason GA, Oudard S, Hariharan S, Lee SH, Haanen J, Castellano D, Vrdoljak E, Schoffski P, Mainwaring P, Nieto A, Yuan J, Bukowski R
Institution:	Royal Marsden Hospital NHS Trust, London, UK. martin.gore@rmh.nhs.uk
Journal:	Lancet Oncol. 2009 Aug;10(8):757-63. Epub 2009 Jul 15.

10:	Immunotherapeutic strategies in kidney cancer--when TKIs are not enough.

Authors:	Biswas S, Eisen T
Institution:	Freeman Hospital, Newcastle upon Tyne, UK.
Journal:	Nat Rev Clin Oncol. 2009 Aug;6(8):478-87. Epub 2009 Jun 23.

11:	Overweight is associated with improved cancer-specific survival in patients with organ-confined renal cell carcinoma.

Authors:	Schrader AJ, Rustemeier J, Rustemeier JC, Timmesfeld N, Varga Z, Hegele A, Olbert PJ, Hofmann R
Institution:	Department of Urology, Philipps-University Medical School, Baldingerstrasse, 35043 Marburg, Germany. ajschrader@gmx.de
Journal:	J Cancer Res Clin Oncol. 2009 Dec;135(12):1693-9. Epub 2009 Jun 20.

12:	Age at diagnosis is an independent predictor of small renal cell carcinoma recurrence-free survival.

Authors:	Jeong IG, Yoo CH, Song K, Park J, Cho YM, Song C, Hong JH, Ahn H, Kim CS
Institution:	Department of Urology, Asan Medical Center, Seoul, Republic of Korea.
Journal:	J Urol. 2009 Aug;182(2):445-50. Epub 2009 Jun 13.

13:	Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma.

Authors:	Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, Garcia-del-Muro X, Sosman JA, Solska E, Wilding G, Thompson JA, Kim ST, Chen I, Huang X, Figlin RA
Institution:	Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA. motzerr@mskcc.org
Journal:	J Clin Oncol. 2009 Aug 1;27(22):3584-90. Epub 2009 Jun 1.

14:	Pediatric renal cell carcinoma.

Authors:	Sausville JE, Hernandez DJ, Argani P, Gearhart JP
Institution:	James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21287, USA. jsausville@smail.umaryland.edu
Journal:	J Pediatr Urol. 2009 Aug;5(4):308-14. Epub 2009 May 14.

15:	Radiofrequency ablation of small renal cortical tumours in healthy adults: renal function preservation and intermediate oncological outcome.

Authors:	Stern JM, Gupta A, Raman JD, Cost N, Lucas S, Lotan Y, Raj GV, Cadeddu JA
Institution:	Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Journal:	BJU Int. 2009 Sep;104(6):786-9. Epub 2009 Apr 4.

16:	Nephrectomy improves survival in patients with invasion of adjacent viscera and absence of nodal metastases (stage T4N0 renal cell carcinoma).

Authors:	Capitanio U, Perrotte P, Zini L, Jeldres C, Shariat SF, Isbarn H, Arjane P, Peloquin F, Pharand D, Montorsi F, Karakiewicz PI
Institution:	Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC, Canada.
Journal:	BJU Int. 2009 Sep;104(6):795-9. Epub 2009 Apr 15.

17:	Complications of image-guided radiofrequency ablation of renal cell carcinoma: causes, imaging features and prevention methods.

Authors:	Park BK, Kim CK
Institution:	The Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Korea. rapark@skku.edu
Journal:	Eur Radiol. 2009 Sep;19(9):2180-90. Epub 2009 Apr 7.

18:	Percutaneous radiofrequency ablation for unresectable pulmonary metastases from renal cell carcinoma.

Authors:	Soga N, Yamakado K, Gohara H, Takaki H, Hiraki T, Yamada T, Arima K, Takeda K, Kanazawa S, Sugimura Y
Institution:	Division of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie, Okayama, Japan. n-soga@clin.medic.mie-u.ac.jp
Journal:	BJU Int. 2009 Sep;104(6):790-4. Epub 2009 Mar 18.

19:	Prospective assessment of systemic therapy followed by surgical removal of metastases in selected patients with renal cell carcinoma.

Authors:	Daliani DD, Tannir NM, Papandreou CN, Wang X, Swisher S, Wood CG, Swanson DA, Logothetis CJ, Jonasch E
Institution:	Medical Oncology Department, University Hospital of Larissa, Mzourlo, Larrissa, Greece.
Journal:	BJU Int. 2009 Aug;104(4):456-60. Epub 2009 Mar 31.

20:	Quality of life and perioperative outcomes after retroperitoneoscopic radical nephrectomy (RN), open RN and nephron-sparing surgery in patients with renal cell carcinoma.

Authors:	Gratzke C, Seitz M, Bayrle F, Schlenker B, Bastian PJ, Haseke N, Bader M, Tilki D, Roosen A, Karl A, Reich O, Khoder WY, Wyler S, Stief CG, Staehler M, Bachmann A
Institution:	Department of Urology, Ludwig-Maximilians-University Munich, Germany. christian.gratzke@med.unimuenchen.de
Journal:	BJU Int. 2009 Aug;104(4):470-5. Epub 2009 Feb 23.

21:	Patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: in vitro results and clinical responses.

Authors:	Zhou J, Weng D, Zhou F, Pan K, Song H, Wang Q, Wang H, Wang H, Li Y, Huang L, Zhang H, Huang W, Xia J
Institution:	State Key Laboratory of Oncology in Southern China, 510060, Guangzhou, People's Republic of China.
Journal:	Cancer Immunol Immunother. 2009 Oct;58(10):1587-97. Epub 2009 Feb 17.

22:	Comparison of rates and risk factors for developing chronic renal insufficiency, proteinuria and metabolic acidosis after radical or partial nephrectomy.

Authors:	Malcolm JB, Bagrodia A, Derweesh IH, Mehrazin R, Diblasio CJ, Wake RW, Wan JY, Patterson AL
Institution:	Department of Urology, University of Tennessee Health Science Center, Memphis, TN, USA.
Journal:	BJU Int. 2009 Aug;104(4):476-81. Epub 2009 Feb 10.

23:	Brain magnetic resonance imaging changes after sorafenib and sunitinib chemotherapy in patients with advanced renal cell and breast carcinoma.

Authors:	Hill KL Jr, Lipson AC, Sheehan JM
Institution:	Penn State Milton S. Hershey Medical Center, Department of Neurosurgery, Hershey, Pennsylvania 17033, USA.
Journal:	J Neurosurg. 2009 Sep;111(3):497-503.

24:	Renal cell carcinoma and arterial hypertension.

Authors:	Stojanovic M, Goldner B, Ivkovic D
Institution:	Regional Medical Center and Hospital, Berane, Montenegro.
Journal:	Clin Exp Nephrol. 2009 Aug;13(4):295-9. Epub 2009 Jan 29.

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