Hereditary Hemochromatosis
June 2016 Issue
 
 
 

Each month hundreds of thousands of consumers and healthcare professionals search the National Library of Medicine's Medline database seeking the latest information on their disease/condition. Conducting a thorough and effective Medline search is both a time consuming and daunting task. At Medifocus, we have developed an effective solution to this problem: each month our staff of expert researchers searches Medline for the latest advances in research and clinical medicine for over 70 diseases / conditions. We do this with one goal in mind: to empower you to effectively take control over your health.

Here is the result of our team's work in Hereditary Hemochromatosis this month:

1:Autoimmune Conditions in 235 Hemochromatosis Probands with HFE C282Y Homozygosity and Their First-Degree Relatives.
Authors:Barton JC
Institution:Southern Iron Disorders Center, Birmingham, AL 35209, USA ; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35209, USA.
Journal:J Immunol Res. 2015;2015:453046. doi: 10.1155/2015/453046. Epub 2015 Oct 4.

2:HFE gene: Structure, function, mutations, and associated iron abnormalities.
Authors:Barton JC, Edwards CQ, Acton RT
Institution:Southern Iron Disorders Center, Birmingham, AL, USA and Department of Medicine; University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: ironmd@isp.com. Lake City, UT, USA. Electronic address: corwin.edwards@imail.org. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: rtakma@bellsouth.net.
Journal:Gene. 2015 Dec 15;574(2):179-92. doi: 10.1016/j.gene.2015.10.009. Epub 2015 Oct 9.

3:Erythrocytapheresis versus phlebotomy in the maintenance treatment of HFE hemochromatosis patients: results from a randomized crossover trial.
Authors:Rombout-Sestrienkova E, Winkens B, Essers BA, Nieman FH, Noord PA, Janssen MC, van Deursen CT, Boonen A, Reuser-Kaasenbrood EP, Heeremans J, van Kraaij M, Masclee A, Koek GH
Institution:Department of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, the Netherlands. University Medical Centre, Maastricht, the Netherlands. Care (CAPHRI), Maastricht University. Nijmegen, the Netherlands. Heerlen/Brunssum/Sittard, the Netherlands. Netherlands. Netherlands. Netherlands. University Medical Centre, Maastricht, the Netherlands. University Medical Centre, Maastricht, the Netherlands.
Journal:Transfusion. 2016 Jan;56(1):261-70. doi: 10.1111/trf.13328. Epub 2015 Sep 10.

4:Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).
Authors:Ong SY, Dolling L, Dixon JL, Nicoll AJ, Gurrin LC, Wolthuizen M, Wood EM, Anderson GJ, Ramm GA, Allen KJ, Olynyk JK, Crawford D, Kava J, Ramm LE, Gow P, Durrant S, Powell LW, Delatycki MB
Institution:Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.; Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia.; Iron Metabolism Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.; Department of Gastroenterology, Eastern Health, Box Hill, Victoria, Australia Department of Gastroenterology, Royal Melbourne Hospital, Parkville, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Journal:BMJ Open. 2015 Aug 12;5(8):e008938. doi: 10.1136/bmjopen-2015-008938.

5:Genetics, Genetic Testing, and Management of Hemochromatosis: 15 Years Since Hepcidin.
Authors:Pietrangelo A
Institution:Unit of Internal Medicine 2 and Centre for Hemochromatosis, University Hospital of Modena, Modena, Italy. Electronic address: antonello.pietrangelo@unimore.it.
Journal:Gastroenterology. 2015 Oct;149(5):1240-1251.e4. doi: 10.1053/j.gastro.2015.06.045. Epub 2015 Jul 9.

6:Epidemiology and diagnostic testing for hemochromatosis and iron overload.
Authors:Adams PC
Institution:Western University, London, ON, Canada.
Journal:Int J Lab Hematol. 2015 May;37 Suppl 1:25-30. doi: 10.1111/ijlh.12347.

7:Serum ferritin is a biomarker for liver mortality in the Hemochromatosis and Iron Overload Screening Study.
Authors:Adams PC, Barton JC, Guo H, Alter D, Speechley M
Institution:Department of Medicine, Western University, London, Ontario, Canada. University of Alabama at Birmingham, Birmingham, Alabama. Canada. Ontario, Canada.
Journal:Ann Hepatol. 2015 May-Jun;14(3):348-53.

8:Update on iron metabolism and molecular perspective of common genetic and acquired disorder, hemochromatosis.
Authors:Yun S, Vincelette ND
Institution:Department of Medicine, University of Arizona, Tucson, AZ 85721, USA. Electronic address: syun@email.arizona.edu. 55902, USA.
Journal:Crit Rev Oncol Hematol. 2015 Jul;95(1):12-25. doi: 10.1016/j.critrevonc.2015.02.006. Epub 2015 Feb 18.

9:Non-invasive assessment of liver fibrosis in C282Y homozygous HFE hemochromatosis.
Authors:Legros L, Bardou-Jacquet E, Latournerie M, Guillygomarc'h A, Turlin B, Le Lan C, Desille Y, Laine F, Moirand R, Brissot P, Deugnier Y, Guyader D
Institution:Liver disease unit and National reference center for rare iron overload diseases of genetic origin, CHU de Rennes, Rennes, France.; Inserm UMR991, CHU de Rennes, Rennes, France.; University of Rennes 1, CHU de Rennes, Rennes, France.; Department of Pathology, CHU de Rennes, Rennes, France.; Clinical Investigation Unit, Inserm CIC0203, CHU de Rennes, Rennes, France.
Journal:Liver Int. 2015 Jun;35(6):1731-8. doi: 10.1111/liv.12762. Epub 2015 Feb 4.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Hereditary Hemochromatosis was not only extremely informative and well-written but it also explained the genetic aspects of this condition in a way that can be readily understood even by people who donít have a medical or scientific background. I was pleased to learn that so much research is ongoing worldwide to try to better understand the causes of this condtion and, hopefully, come up with a way to prevent this disorder from happening in the first place."
S.D.R.
Perth Amboy, New Jersey


"Your Guidebook on Hereditary Hemochromatosis contains a wealth of information that has helped our family answer many of the questions we had about this relatively obscure genetic disease. The Guidebook allowed us to fully understand the disease and know what to ask...and who to ask to additional information."
D.J.
St. Joseph, Missouri



  
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