Hereditary Hemochromatosis
January 2015 Issue

Each month hundreds of thousands of consumers and healthcare professionals search the National Library of Medicine's Medline database seeking the latest information on their disease/condition. Conducting a thorough and effective Medline search is both a time consuming and daunting task. At Medifocus, we have developed an effective solution to this problem: each month our staff of expert researchers searches Medline for the latest advances in research and clinical medicine for over 70 diseases / conditions. We do this with one goal in mind: to empower you to effectively take control over your health.

Here is the result of our team's work in Hereditary Hemochromatosis this month:

1:Non HFE related hereditary haemochromatosis.
Authors:Sharma SK, Mangudkar S, Rathod M, Verma A, Phanikumar RL, Garg S, Dhakne A, Barure R
Journal:J Assoc Physicians India. 2014 Mar;62(3):264-7.

2:Diabetes and hemochromatosis.
Authors:Creighton Mitchell T, McClain DA
Institution:Department of Medicine, Division of Endocrinology, University of Utah, 15 North 2030 East, Salt Lake City, UT, 84108, USA.
Journal:Curr Diab Rep. 2014;14(5):488. doi: 10.1007/s11892-014-0488-y.

3:Cardiac involvement in hemochromatosis.
Authors:Gulati V, Harikrishnan P, Palaniswamy C, Aronow WS, Jain D, Frishman WH
Institution:From the *Department of Medicine, University of Connecticut Health Center, Farmington, CT; and daggerDivision of Cardiology, Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY.
Journal:Cardiol Rev. 2014 Mar-Apr;22(2):56-68. doi: 10.1097/CRD.0b013e3182a67805.

4:H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
Authors:Ali-Rahmani F, Grigson PS, Lee S, Neely E, Connor JR, Schengrund CL
Institution:Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Journal:Neurobiol Aging. 2014 Jun;35(6):1511.e1-12. doi: 10.1016/j.neurobiolaging.2013.12.014. Epub 2013 Dec 25.

5:Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.
Authors:Pretorius E, Bester J, Vermeulen N, Lipinski B, Gericke GS, Kell DB
Institution:Department of Physiology, University of Pretoria, Arcadia, South Africa.
Journal:PLoS One. 2014 Jan 9;9(1):e85271. doi: 10.1371/journal.pone.0085271. eCollection 2014.

6:Hereditary hemochromatosis, iron, hepcidin, and coronary heart disease.
Authors:Mascitelli L, Goldstein MR
Institution:Comando Brigata alpina "Julia"/Multinational Land Force, Medical Service, 8 Via S. Agostino, Udine 33100, Italy. Electronic address:; NCH Physicians Group, 1845 Veterans Park Drive, Suite 110, Naples, FL 34109, USA.
Journal:Med Hypotheses. 2014 Mar;82(3):402-3. doi: 10.1016/j.mehy.2013.12.013. Epub 2013 Dec 25.

7:Erythrocytapheresis compared with whole blood phlebotomy for the treatment of hereditary haemochromatosis.
Authors:Sundic T, Hervig T, Hannisdal S, Assmus J, Ulvik RJ, Olaussen RW, Berentsen S
Institution:Department of Immunology and Transfusion Medicine, Haugesund Hospital, Helse Fonna, Haugesund, Norway.
Journal:Blood Transfus. 2014 Jan;12 Suppl 1:s84-9. doi: 10.2450/2013.0128-13. Epub 2013 Oct 23.

8:Metal storage disorders: Wilson disease and hemochromatosis.
Authors:Kanwar P, Kowdley KV
Institution:Liver Center of Excellence, Department of Gastroenterology, Digestive Disease Institute, Virginia Mason Medical Center, 1100 9th Avenue, Mailstop C3-GAS, Seattle, WA 98101, USA.
Journal:Med Clin North Am. 2014 Jan;98(1):87-102. doi: 10.1016/j.mcna.2013.09.008. Epub 2013 Oct 28.

9:HFE-related hemochromatosis: an update for the rheumatologist.
Authors:Husar-Memmer E, Stadlmayr A, Datz C, Zwerina J
Institution:Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich-Collin-Strasse 30, 1140, Vienna, Austria.
Journal:Curr Rheumatol Rep. 2014 Jan;16(1):393. doi: 10.1007/s11926-013-0393-4.

10:Total and cause-specific mortality by elevated transferrin saturation and hemochromatosis genotype in individuals with diabetes: two general population studies.
Authors:Ellervik C, Mandrup-Poulsen T, Tybjaerg-Hansen A, Nordestgaard BG
Institution:Corresponding author: Christina Ellervik,
Journal:Diabetes Care. 2014 Feb;37(2):444-52. doi: 10.2337/dc13-1198. Epub 2013 Oct 15.

11:TFR2-related hereditary hemochromatosis as a frequent cause of primary iron overload in patients from Central-Southern Italy.
Authors:Radio FC, Majore S, Binni F, Valiante M, Ricerca BM, De Bernardo C, Morrone A, Grammatico P
Institution:Medical Genetics, Molecular Medicine Department, Sapienza University of Rome, San Camillo-Forlanini Hospital, Rome, Italy. Electronic address:
Journal:Blood Cells Mol Dis. 2014 Feb-Mar;52(2-3):83-7. doi: 10.1016/j.bcmd.2013.08.003. Epub 2013 Sep 20.

12:Endoscopic and histologic abnormalities of gastrointestinal tract in patients with hereditary hemochromatosis.
Authors:Zhou WX, Wu XR, Bennett AE, Shen B
Institution:*Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China Departments of daggerAnatomic Pathology double daggerColorectal Surgery section signGastroenterology/Hepatology, The Cleveland Clinic Foundation, Cleveland, OH.
Journal:J Clin Gastroenterol. 2014 Apr;48(4):336-42. doi: 10.1097/MCG.0b013e3182a9be10.

13:Phenotypic expression of a novel C282Y/R226G compound heterozygous state in HFE hemochromatosis: molecular dynamics and biochemical studies.
Authors:Cezard C, Rabbind Singh A, Le Gac G, Gourlaouen I, Ferec C, Rochette J
Institution:Laboratoire des Glucides, CNRS FRE 3517, Universite de Picardie Jules Verne, Amiens 80037 Cedex 1, France.
Journal:Blood Cells Mol Dis. 2014 Jan;52(1):27-34. doi: 10.1016/j.bcmd.2013.07.011. Epub 2013 Aug 14.

14:Distribution and quantitation of skin iron in primary haemochromatosis: correlation with total body iron stores in patients undergoing phlebotomy.
Authors:Pinheiro T, Silva R, Fleming R, Goncalves A, Barreiros MA, Silva JN, Morliere P, Santus R, Filipe P
Institution:IST-ITN, Instituto Superior Tecnico, Universidade Tecnica de Lisboa aand Centro de Fisica Nuclear, UL, E.N. 10, 2685-953 Sacavem, Portugal.
Journal:Acta Derm Venereol. 2014 Jan;94(1):14-9. doi: 10.2340/00015555-1601.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Hereditary Hemochromatosis was not only extremely informative and well-written but it also explained the genetic aspects of this condition in a way that can be readily understood even by people who donít have a medical or scientific background. I was pleased to learn that so much research is ongoing worldwide to try to better understand the causes of this condtion and, hopefully, come up with a way to prevent this disorder from happening in the first place."
Perth Amboy, New Jersey

"Your Guidebook on Hereditary Hemochromatosis contains a wealth of information that has helped our family answer many of the questions we had about this relatively obscure genetic disease. The Guidebook allowed us to fully understand the disease and know what to ask...and who to ask to additional information."
St. Joseph, Missouri

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