Medifocus Digest Alert on Hereditary Hemochromatosis


	Hereditary Hemochromatosis June 2009 Issue

Each month hundreds of thousands of consumers and healthcare professionals search the National Library of Medicine's Medline database seeking the latest information on their disease/condition. Conducting a thorough and effective Medline search is both a time consuming and daunting task. At Medifocus, we have developed an effective solution to this problem: each month our staff of expert researchers searches Medline for the latest advances in research and clinical medicine for over 70 diseases / conditions. We do this with one goal in mind: to empower you to effectively take control over your health.

Here is the result of our team's work in Hereditary Hemochromatosis this month:

1: Marked iron in liver explants in the absence of major hereditary hemochromatosis gene defects: a risk factor for cardiac failure.

Authors: Fenton H, Torbenson M, Vivekanandan P, Yeh MM, Hart J, Ferrell L

Institution: Department of Pathology, University of California, San Francisco, CA, USA.
Journal: Transplantation. 2009 Apr 27;87(8):1256-60.

2: Diagnosis of hepatic iron overload: a family study illustrating pitfalls in diagnosing hemochromatosis.

Authors: Schranz M, Talasz H, Graziadei I, Winder T, Sergi C, Bogner K, Vogel W, Zoller H

Institution: Department of Medicine, Clinical Division of Gastroenterology and Hepatology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria.
Journal: Diagn Mol Pathol. 2009 Mar;18(1):53-60.

3: New pharmacological concepts for the treatment of iron overload disorders.

Authors: Mair SM, Weiss G

Institution: Medicinal University of Innsbruck, Department of General Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck, Austria.
Journal: Curr Med Chem. 2009;16(5):576-90.

4: Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis.

Authors: Crawford DH, Murphy TL, Ramm LE, Fletcher LM, Clouston AD, Anderson GJ, Subramaniam VN, Powell LW, Ramm GA

Institution: School of Medicine, The University of Queensland, Greenslopes Private Hospital, Brisbane, Australia. edwardc@mbasis.com
Journal: Hepatology. 2009 Feb;49(2):418-25.

5: Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study.

Authors: Jacobs EM, Hendriks JC, van Deursen CT, Kreeftenberg HG, de Vries RA, Marx JJ, Stalenhoef AF, Verbeek AL, Swinkels DW

Institution: Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Journal: J Hepatol. 2009 Jan;50(1):174-83. Epub 2008 Oct 14.

6: Non-classical hereditary hemochromatosis in Portugal: novel mutations identified in iron metabolism-related genes.

Authors: Mendes AI, Ferro A, Martins R, Picanco I, Gomes S, Cerqueira R, Correia M, Nunes AR, Esteves J, Fleming R, Faustino P

Institution: Human Genetics Centre, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal.
Journal: Ann Hematol. 2009 Mar;88(3):229-34. Epub 2008 Sep 2.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Hereditary Hemochromatosis was not only extremely informative and well-written but it also explained the genetic aspects of this condition in a way that can be readily understood even by people who don’t have a medical or scientific background. I was pleased to learn that so much research is ongoing worldwide to try to better understand the causes of this condtion and, hopefully, come up with a way to prevent this disorder from happening in the first place."
S.D.R.
Perth Amboy, New Jersey